Haploidy-linked cell proliferation defects limit larval growth in zebrafish [PDF]
Open BiologyHaploid larvae in non-mammalian vertebrates are lethal, with characteristic organ growth retardation collectively called ‘haploid syndrome’. In contrast to mammals, whose haploid intolerance is attributed to imprinting misregulation, the cellular ...
Kan Yaguchi +8 more
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The use of maize haploidy inducers as a tool in agricultural plant biotechnology [PDF]
Вавиловский журнал генетики и селекции, 2022 The discovery of the ability of some mutations to stimulate haploidy during hybridization made it possible to create one of the most promising and sought-after trends in the field of reproductive biology.
A. V. Ulyanov +2 more
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Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas [PDF]
Frontiers in OncologyThe mitogen-activated protein kinase (MAPK) signaling pathway plays roles in cell proliferation, differentiation, and apoptosis, all crucial for cellular transformation. It’s no surprise that MAPK alterations are prevalent in numerous tumors.
Ruze Tang +15 more
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Effect of Small Molecules on Blastocyst Development and Outgrowth Establishment of Bovine Haploid Parthenogenetic Embryos [PDF]
AnimalsHaploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts.
Luis Aguila +8 more
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Androgenesis-Based Doubled Haploidy: Past, Present, and Future Perspectives
Frontiers in Plant Science, 2022 Androgenesis, which entails cell fate redirection within the microgametophyte, is employed widely for genetic gain in plant breeding programs. Moreover, androgenesis-responsive species provide tractable systems for studying cell cycle regulation, meiotic
Alison Ferrie +2 more
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Imprinting as Basis for Complex Evolutionary Novelties in Eutherians [PDF]
BiologyThe epigenetic phenomenon of genomic imprinting is puzzling. While epigenetic modifications in general are widely known in most species, genomic imprinting in the animal kingdom is restricted to autosomes of therian mammals, mainly eutherians, and to a ...
Maximillian Schuff +3 more
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Haploid Induction in Tomato (Solanum lycopersicum L.) via Gynogenesis [PDF]
Plants, 2022 The generation of new hybrid varieties of tomato (Solanum lycopersicum L.) is the most widely used breeding method for this species and requires at least seven self-fertilization cycles to generate stable parent lines. The development of doubled haploids
Ivan Maryn Marin-Montes +5 more
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Balanced DNA-to-cytoplasm ratio at the 2-cell stage is critical for mouse preimplantation development [PDF]
iScienceSummary: Among vertebrates, mammalian haploid embryos are highly prone to early developmental arrest for reasons that remain unclear. Using mouse preimplantation embryos with altered cell size and ploidy, we show that arrest primarily results from an ...
Tao Pan, Natsumi Taira, Miho Ohsugi
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A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells
Cell Reports, 2019 Summary: The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth ...
Maria Vega Sendino +2 more
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Haploid induction: an overview of parental factor manipulation during seed formation [PDF]
Frontiers in Plant ScienceIn plants, in vivo haploid induction has gained increasing attention for its significant potential applications in crop breeding and genetic research.
Jingpu Song +3 more
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