Results 91 to 100 of about 57,032 (271)

Protein changes as robust signatures of fish chronic stress: a proteomics approach to fish welfare research [PDF]

, 2020
Background Aquaculture is a fast-growing industry and therefore welfare and environmental impact have become of utmost importance. Preventing stress associated to common aquaculture practices and optimizing the fish stress response by ...
Cerqueira, Marco, Farinha, Ana Paula, Kuehn, Annette, Planchon, Sébastien, Raposo de Magalhães, Cláudia, Revets, Dominique, Rodrigues, Pedro, Schrama, Denise   +7 more
core  

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari   +13 more
wiley   +1 more source

Digenic Functional B12 and Folate Defect Mimicking Myelodysplasia

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Proposed mechanistic model of mutation‐related outcomes. ABSTRACT A digenic defect involving CUBN and MTHFR produced functional B12/folate deficiency in a patient with pancytopenia and neurological signs, mimicking myelodysplasia. Genetic and metabolic screening revealed elevated methylmalonic acid/homocysteine, with rapid remission post‐parenteral B12.
Thomas Cluzeau, Abderrahim Oussalah, Maël Silva Rodriguez, Mourad Naïmi   +3 more
wiley   +1 more source

Early post parturient changes in milk acute phase proteins [PDF]

, 2016
The periparturient period is one of the most critical periods in the productive life of a dairy cow, and is the period when dairy cows are most susceptible to developing new intramammary infections (IMI) leading to mastitis.
Eckersall, Peter, Haining, Hayley, Hastie, Peter, Thomas, Funmilola C., Waterston, Mary   +4 more
core   +1 more source

Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei

Frontiers in Immunology
Haptoglobin is a plasma protein of mammals that plays a crucial role in vascular homeostasis by binding free haemoglobin released from ruptured red blood cells.
Eva Horáková, Eva Horáková, Marek Vrbacký, Martina Tesařová, Eva Stříbrná, Jan Pilný, Zuzana Vavrušková, Marie Vancová, Marie Vancová, Roman Sobotka, Roman Sobotka, Julius Lukeš, Julius Lukeš, Jan Perner   +13 more
doaj   +1 more source

Free Fetal Haemoglobin in Severe Early‐Onset Fetal Growth Restriction: A Prospective Multi‐Centre Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 401-411, February 2026.
ABSTRACT Objective To assess fetal circulating free fetal haemoglobin (fHbF) levels and heme defences, correlated to fetal circulatory biometry and fetal sex in severe early‐onset fetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset fetal growth restriction pregnancies with close clinical management ...
Adam Brook, Georgia Baynes, Jonathan Scargill, Angelos Evangelinos, Charlotte Brennan‐Richardson, Freya Dow, Yuval Ginsberg, Tal Weissbach, Jana Brodszki, Eva Hansson, Anke Diemert, Kurt Hecher, Katarzyna Maksym, Neil Marlow, Rebecca N. Spencer, Anna L. David, Stefan R. Hansson, Paul Brownbill   +17 more
wiley   +1 more source

Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation [PDF]

, 2013
Two ruminant acute phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were evaluated as serum biomarkers (BMs) for sheep scab–a highly contagious ectoparasitic disease caused by the mite Psoroptes ovis, which is a major welfare and ...
Burgess, Stewart TG, Eckersall, Peter D, Innocent, Giles T, Mcculloch, Eilidh, Nisbet, Alasdair J, Wells, Beth   +5 more
core   +1 more source

Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 222-231, February 2026.
ABSTRACT Aim To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC).
Hélvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Cássia F. Araújo, Angelika Silbereisen, Mauro P. Santamaria, Nagihan Bostanci, Renato C. V. Casarin   +7 more
wiley   +1 more source

Concentration of plasma haptoglobin and symptomatic cerebral vasospasm after subarachnoid hemorrhage

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
The relation of plasma haptoglobin concentration to symptomatic cerebral vasospasm (SCVS) after subarachnoid hemorrhage (SAH) was investigated. The plasma concentration of haptoglobin was analyzed by enzyme-linked immunosorbent assay (ELISA).
Qun MAO, Hui-jie WEI, Huan-yu WANG, Xiao-guang TONG, Yi-mu FAN, Jian-ning ZHANG   +5 more
doaj  

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source