Results 91 to 100 of about 850,081 (293)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
, 2011 Outlines how hiring and mobilizing people who use drugs helps improve harm reduction programs. Offers policies for the workplace; strategies for recruitment, training, supervision, support, discipline, and conflict resolution; and two case ...
Cheryl White, Raffi Balian
core
Exploring internal child sex trafficking networks using social network analysis [PDF]
, 2011 This article explores the potential of social network analysis as a tool in supporting the investigation of internal child sex trafficking in the UK. In doing so, it uses only data, software, and training already available to UK police.
Brayley, H, Cockburn, E, Laycock, G
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Women, harm reduction, and HIV [PDF]
, 2007 Based on a literature review, examines how gender affects women drug users' access to harm reduction, drug treatment, and sexual and reproductive health services -- and their risk of HIV infection.
Malinowska-Sempruch, Kasia +1 more
core
An evaluation of harm reduction Kits distrubution [PDF]
, 2006 The PRD Sampa (the Sampa Harm Reduction Project) was initiated in the Mental Health District of São Paulo to implement a harm reduction policy for drug and alcohol users in the city and reduce their exposure to sexually transmitted diseases - STDs and ...
Da Ros, Vera [UNIFESP] +2 more
core +4 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Supply-side reduction policy and drug-related harm [PDF]
Large-scale seizures of cocaine, heroin and amphetamine-type substances (ATS) do not result in any reduction in overdoses on these drugs or on arrests for use and possession of these drugs, according to this report.
Don Weatherburn +4 more
core +1 more source
Harm Reduction: Public Health and Public Order [PDF]
, 2007 Reviews international literature on harm reduction programs and their impact on crime and public order, with a focus on medication-assisted treatment and needle exchange programs for drug ...
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source