Results 91 to 100 of about 824,404 (357)

New psychoactive substances in Eurasia: a qualitative study of people who use drugs and harm reduction services in six countries

open access: yesHarm Reduction Journal, 2020
Background This study examines the use of new psychoactive substances (NPS) and the harm reduction response in six Eurasian countries: Belarus, Moldova, Serbia, Kazakhstan, Kyrgyzstan, and Georgia.
Eliza Kurcevič, Rick Lines
doaj   +1 more source

Can the Heinrich ratio be used to predict harm from medication errors? [PDF]

open access: yes, 2006
The purpose of this study was to establish whether, for medication errors, there exists a fixed Heinrich ratio between the number of incidents which did not result in harm, the number that caused minor harm, and the number that caused serious harm.
Barber, N   +3 more
core  

Disagreement, Unenforceability, and Harm Reduction [PDF]

open access: yesHealth Care Analysis, 2020
Talk of harm reduction has expanded horizontally, to apply to an ever-widening range of policy domains, and vertically, becoming part of official legal and political discourse. This expansion calls for philosophical theorization. What is the best way in which to characterize harm reduction? Does it represent a distinctive ethical position?
openaire   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Exploring internal child sex trafficking networks using social network analysis [PDF]

open access: yes, 2011
This article explores the potential of social network analysis as a tool in supporting the investigation of internal child sex trafficking in the UK. In doing so, it uses only data, software, and training already available to UK police.
Brayley, H, Cockburn, E, Laycock, G
core   +1 more source

Prescribing cannabis for harm reduction [PDF]

open access: yesHarm Reduction Journal, 2012
Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning.
openaire   +4 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Harm Reduction: Public Health and Public Order [PDF]

open access: yes, 2007
Reviews international literature on harm reduction programs and their impact on crime and public order, with a focus on medication-assisted treatment and needle exchange programs for drug ...

core  

Motivational Interviewing Impact on Cardiovascular Disease [PDF]

open access: yes, 2020
: Harm reduction in cardiovascular disease is a significant problem worldwide. Providers, families, and healthcare agencies are feeling the burdens imparted by these diseases.

core  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

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