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Effects of harmaline on anxiety-related behavior in mice [PDF]
Physiology and Behavior, 2005 Harmaline (HA) is a beta-carboline commonly known to provoke motor alterations through activation of cells in the inferior olive. In addition, this pharmacological agent also induces cognitive disturbances such as motor and spatial learning impairments. In order to complete and extend these data, we examined the effects of this drug on state anxiety in
Pascal Hilber
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Induction of Rhythmic Activity by Harmaline [PDF]
Canadian Journal of Physiology and Pharmacology, 1974 Microiontophoretic application of harmaline evoked rhythmic multiunit activity in the inferior olive of decerebrate cats. Harmaline caused strong excitation of individual olivary neurones but did not seem to cause them to discharge in high frequency bursts. These effects suggest that the tremorgenic action of harmaline may be due to an exaggeration of
Y, Lamarre, E, Puil
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Neurophysiological Studies of Harmaline-Induced Tremor in the Cat [PDF]
Canadian Journal of Physiology and Pharmacology, 1971 Harmaline induces in the cat a generalized tremor, synchronous in all muscles, at a frequency of 8–12/s. This tremor has a central origin since motoneuronal rhythmic firing persists after paralysis or deafferentation. Intracellular recordings of lumbar motoneurons reveal spontaneous rhythmic EPSPs under harmaline; this rhythmic activity is not reset ...
Y, Lamarre, L A, Mercier
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The mechanism of action of harmaline on renal solute transport [PDF]
Pflügers Archiv European Journal of Physiology, 1977 The effect of the hallucinogenic drug harmaline was tested on rat kidney proximal tubular solute and water transport, using in vivo micropuncture and electrophysiological techniques as well as in vitro biochemical techniques. During peritubular application harmaline (5 mmol/l) was found to block net tubular volume absorption reversibly (by 85%) through
Samaržija, I. +3 more
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Photophysics of harmaline in solvent mixtures
Journal of Molecular Liquids, 2019Abstract In this article the photophysics of an alkaloid harmaline in acetonitrile-water and dimethyl sulfoxide-water mixtures were reported. Depending on the amount of water present in these two mixtures the microstructure of these binary mixtures changes.
Rabindranath Jana, Debabrata Seth
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The effect of memantine in harmaline-induced tremor and neurodegeneration [PDF]
Neuropharmacology, 2011 Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA
Ertürk, Sarp +7 more
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Pharmacokinetics in the rat of the hallucinogenic alkaloids harmine and harmaline
Naunyn-Schmiedeberg's Archives of Pharmacology, 19741. After i. v. injection in rats, harmine and harmaline were distributed in the organism within a few seconds. In spite of the close chemical relationship, both alkaloids revealed significant pharmacokinetic differences. 2. Highest concentrations occurred for harmine in the lung and for harmaline in the kidney.
Zetler G, G Zetler
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Influence of drugs on the temperature-lowering effect of harmaline
European Journal of Pharmacology, 1968Harmaline (30 mg/kg), injected intraperitoneally into rats, causes a decrease in body temperature. Treatment with either α-methyl-dopa (200 mg/kg, i.p.) or with a-methyltyrosine (200 mg/kg, i.p.) 24 hr before, or with p-chlorophenylalanine (315 mg/kg, i.p.) 72 hr before injection of haarmaline, did not influence the decrease in temperature ...
T L Sourkes, T L Sourkes, J Bruinvels
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Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy [PDF]
Food Chemistry, 2012 The β-carboline alkaloids, harmaline and harmine, are present in hallucinogenic plants Ayahuasca and Peganum harmala, and in a variety of foods. In order to establish the metabolic pathway and bioactivities of endogenous and xenobiotic bioactive β ...
Chang Hong Wang +2 more
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