Results 161 to 170 of about 3,248 (213)

Computational insights into harmala alkaloids as novel antimalarial candidates against Plasmodium falciparum. [PDF]

Sci Rep
Dipto KZ, Shariar R, Saha CK, Huzaifa A, Robin TB, Patil RB, Alam MT, Rafi MIH, Faruk MAZ, Moin AT, Zinnah KMA, Hasanuzzaman M, Islam T.   +12 more
europepmc   +1 more source

Modulation of Cerebellar Nuclear Activity by Transcranial AC Stimulation in Awake Rats. [PDF]

Annu Int Conf IEEE Eng Med Biol Soc
Kavakli N, Hammad S, Sahin M.
europepmc   +1 more source

Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism. [PDF]

Int J Mol Sci
Buneeva O, Medvedev A.
europepmc   +1 more source

Plant Alkaloids as Promising Anticancer Compounds with Blood-Brain Barrier Penetration in the Treatment of Glioblastoma: In Vitro and In Vivo Models. [PDF]

Molecules
Ożarowski M, Karpiński TM, Czerny B, Kamiński A, Seremak-Mrozikiewicz A.   +4 more
europepmc   +1 more source

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Recent pharmacological developments in β-carboline alkaloid “harmaline”

European Journal of Pharmacology, 2013
Peganum harmala (L) is a perennial plant which is native of eastern Iranian and west of India but also found in different regions of western USA. A number of β-carboline compounds with therapeutic importance and different pharmacological effects, are present in this plant.
Aneela Maalik, Zafar Iqbal
exaly   +3 more sources

Pharmacological characterization of harmaline-induced tremor activity in mice

European Journal of Pharmacology, 2009
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor activity was dependent on harmaline dose. The first-line clinical essential tremor treatments propranolol, primidone and gabapentin and gamma-hydroxybutyrate (GHB) significantly attenuated harmaline ...
Paterson, N.E., Malekiani, S.A., Foreman, M.M., Olivier, B., Hanania, T.   +4 more
exaly   +4 more sources

Metabolism of harmaline in rats

Biochemical Pharmacology, 1971
Abstract The distribution and metabolic fate of [3H]harmaline-HCl were studied in rats. Thirty min after subcutaneous injection, high radioactivity was found in the small intestine, liver, adrenals, kidneys and lungs. A rapid turnover and elimination was evident after the first hour, as most of the tissues, except the liver, kidneys and intestines ...
B T, Ho, V, Estevez, G E, Fritchie, L W, Tansey, J, Idänpään-Heikkilä, W M, McIsaac   +5 more
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Induction of Rhythmic Activity by Harmaline

Canadian Journal of Physiology and Pharmacology, 1974
Microiontophoretic application of harmaline evoked rhythmic multiunit activity in the inferior olive of decerebrate cats. Harmaline caused strong excitation of individual olivary neurones but did not seem to cause them to discharge in high frequency bursts. These effects suggest that the tremorgenic action of harmaline may be due to an exaggeration of
Y, Lamarre, E, Puil
openaire   +2 more sources

Exacerbation of harmaline-induced tremor by imipramine

Pharmacology Biochemistry and Behavior, 2005
Imipramine is a well-established tricyclic antidepressant which was first approved for the treatment of depression in the late fifties. Antidepressant effect of imipramine is attributed to inhibition of serotonin (5HT) and noradrenaline (NA) reuptake in brain. These monoamines have been implicated in a variety of neurological disorders including tremor.
Mohammed, Arshaduddin, Saeed, Kadasah, Saleh, Al Deeb, Khalaf, Al Moutaery, Mohammad, Tariq   +4 more
openaire   +2 more sources