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Baclofen attenuates harmaline induced tremors in rats
Neuroscience Letters, 2001Recent experimental and clinical studies clearly suggest the role of gamma-aminobutyric acid (GABA) in the pathogenesis of tremors. The present study was undertaken to investigate the effect of baclofen, a GABA B receptor agonist on harmaline induced tremors.
M, Tariq +4 more
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Apomorphine enhances harmaline-induced tremor in rats
Pharmacological Reports, 2015Harmaline-induced tremor is a well-known model of essential tremor in humans. The aim of the present study was to examine the influence of apomorphine, a non-selective dopamine receptor agonist, on the tremor induced by harmaline in rats. Propranolol (a first-line drug in essential tremor) was used as a reference compound.Tremor, locomotor activity and
Krystyna, Ossowska +3 more
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Vagus nerve stimulation inhibits harmaline-induced tremor
Brain Research, 2004Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. This system receives rich sensory inputs, including visceral. We hypothesized that electrical vagus nerve stimulation (VNS) would suppress harmaline tremor, as measured with digitized motion power in the rat.
Scott E, Krahl +2 more
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Harmaline, a potent inhibitor of sodium-dependent transport
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1974Abstract Harmaline, a hallucinogenic alkaloid, inhibits sugar and amino acid transport by the guinea-pig intestinal mucosa in vitro during short and long incubations. It affects sodium-dependent transport systems in other tissues such as the dog colonic mucosa and renal cortex slices, but does not influence sodium-independent transport.
F V, Sepúlveda, J W, Robinson
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Photophysics of harmaline in solvent mixtures
Journal of Molecular Liquids, 2019Abstract In this article the photophysics of an alkaloid harmaline in acetonitrile-water and dimethyl sulfoxide-water mixtures were reported. Depending on the amount of water present in these two mixtures the microstructure of these binary mixtures changes.
Rajkumar Sahoo +2 more
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Harmaline disrupts acquisition of conditioned nictitating membrane responses
Brain Research Bulletin, 1984A basic tenet of the Marr-Albus theory of motor learning is that the learning process involves concurrent activation of the climbing fibre and mossy fibre inputs to the cerebellum. This theory was tested by administering harmaline, a drug which causes climbing fibres to fire at their maximal rate of 8-12 Hz, to rabbits during a classical conditioning ...
K S, Türker, T S, Miles
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Canadian Journal of Chemistry, 1959
The synthesis of 1-methyl-3,4-dihydro-β-carboline (harmalan) and of two of its derivatives by dehydration of the corresponding 1-hydroxymethyl-1,2,3,4-tetrahydro-β-carbolines is described. Harmalan was also obtained by oxidative decarboxylation of 1-methyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid.
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The synthesis of 1-methyl-3,4-dihydro-β-carboline (harmalan) and of two of its derivatives by dehydration of the corresponding 1-hydroxymethyl-1,2,3,4-tetrahydro-β-carbolines is described. Harmalan was also obtained by oxidative decarboxylation of 1-methyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid.
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Neurophysiological Studies of Harmaline-Induced Tremor in the Cat
Canadian Journal of Physiology and Pharmacology, 1971Harmaline induces in the cat a generalized tremor, synchronous in all muscles, at a frequency of 8–12/s. This tremor has a central origin since motoneuronal rhythmic firing persists after paralysis or deafferentation. Intracellular recordings of lumbar motoneurons reveal spontaneous rhythmic EPSPs under harmaline; this rhythmic activity is not reset ...
Y, Lamarre, L A, Mercier
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Effect of harmaline on the cerebello-rubral system
Experientia, 1977Harmaline induces synchronous rhythms in both the cerebellum and the red nucleus of the rabbit. The level of synchronization is lower in the red nucleus than in the cerebellar cortex, probably because the cerebello-rubral pathway and the red nucleus neurons only participate poorly in the harmaline-induced olivo-cerebellar rhythm.
G, Gogolák, R, Jindra, C, Stumpf
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Experimental Brain Research, 1981
Changes of local cerebral glucose consumption under the effect of tremogenic doses of harmaline were studied. To find the brain structures activated by the drug, the autoradiographic method using [14C]2-deoxyglucose was applied to young cats. After administration of harmaline, the animals were paralized with flaxedil.
C, Batini +2 more
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Changes of local cerebral glucose consumption under the effect of tremogenic doses of harmaline were studied. To find the brain structures activated by the drug, the autoradiographic method using [14C]2-deoxyglucose was applied to young cats. After administration of harmaline, the animals were paralized with flaxedil.
C, Batini +2 more
openaire +2 more sources