Results 41 to 50 of about 3,248 (213)

Antibacterial and Oxacillin Resistance Reversing Effect of Harmaline in Different Strains of Staphylococcus Aureus [PDF]

Al-Anbar Medical Journal
Background: Harmaline is a naturally occurring indole alkaloid with many medicinal effects. Its antimicrobial effect against different pathogens has been reported previously.Objective: To explore the ability of harmaline to revers oxacillin resistance in
Zaid Ibraheem
doaj   +1 more source

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor [PDF]

, 2016
Cognitive and motor disturbances are serious consequences of tremor induced by motor disorders. Despite a lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of ...
Abush, Adám, Al-Deeb, Arjmand, Barzegar, Benjamin J. Whalley, Bilkei-Gorzo, Chemin, Clifford, Dahhaoui, Daniel, Fitzgerald, Handforth, Hasanein, Hassan Abbassian, Hilber, Howard, Iraj Aghaei, Jackson, Janicki, Jenniches, Khan, Kowal, Kowal, Kruk-Slomka, Mahshid Tahamtan, Mohammad Shabani, Moura, Murillo-Rodríguez, Nasehi, Nasehi, Nasehi, Nasehi, Nazeri, Parisa Esmaeili, Razavinasab, Reilly, Schofield, Shabani, Shabani, Shabani, Shen, Taylor, Vahid Sheibani, Vaziri, Ware, Wecker, Zarrindast, Zohreh Vaziri   +48 more
core   +1 more source

Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus ...
Bahareh Amin, Mahshad Malekzadeh, Mahmoud Reza Heidari, Hossein Hosseinzadeh   +3 more
doaj  

Steady‐state Purkinje cell activity has limited predictive power for cerebellar output in disease

The Journal of Physiology, EarlyView.
Abstract figure legend Cerebellar dysfunction can give rise to various movement disorders. Misfiring cerebellar neurons often underlie this dysfunction. Because Purkinje cells form inhibitory synapses onto cerebellar nuclei cells, it has been presumed that spike activity changes in Purkinje cells cause inverse spike activity changes in the downstream ...
Alyssa M Lyon, Viviana Hernandez‐Castanon, Meike E van der Heijden   +2 more
wiley   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Harmaline Attenuates Voltage - Sensitive Ca2+ Currents in Neurons of the Inferior Olive

Journal of Pharmacy & Pharmaceutical Sciences, 2012
Purpose. Harmaline is one member of a class of tremorgenic harmala alkaloids that have been implicated in neuroprotective effects and neurodegenerative disorders.
Xiping Zhan, Werner M Graf
doaj   +1 more source

Considerations Using Harmaline for a Primate Model of Tremor

Tremor and Other Hyperkinetic Movements, 2021
While harmaline has been used as a pharmacological model of essential tremor (ET) in rodents and pigs, less is known about the effects of this pharmacological treatment in awake-behaving non-human primates. In this study, we investigated the time-course, amplitude, frequency, and consistency of harmaline tremor in primates.Three rhesus macaques were ...
Edward M. Bello, Madeline Blumenfeld, Joan Dao, Jordan D. S. Krieg, Lucius K. Wilmerding, Matthew D. Johnson   +5 more
openaire   +3 more sources

Anti fungal activity of alcoholic extract of Peganum harmala seeds [PDF]

, 2011
In our study, it was aimed to determine antifungal activity of Peganum harmala on medically important yeasts and molds in vitro. Fungal suspensions of Candida spp and aspergillus spp isolated from the clinical specimens were treated with serial dilutions
Diba, K., Khorshivand, Z., Shabatkhori, M., Shoar, M.G.   +3 more
core  

Evaluation of the Bioactive and Technological Potential of Caferana (Bunchosia glandulifera)

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Caferana (Bunchosia glandulifera), one of seven species of the genus Bunchosia identified in the Atlantic Forest, is a plant with expressive bioactive potential that remains underexplored by scientific research. Based on ancestral knowledge and popular traditions that consuming the fruit and infusions made from its roots and leaves may improve physical
Sara Fraga, Lílian Bozzi Barbeiro, Gabriel Sthefano Lourenço Pereira, Patrícia Tonon de Souza, Guilherme José Maximo, Antonio José de Almeida Meirelles, Daniel Gonçalves, Klicia Araujo Sampaio, Isaac Duah Boateng   +8 more
wiley   +1 more source

Biologic Activity and Biotechnological Development of Natural Products [PDF]

, 2013
Rod Juscelino Kubitschek, BR-68903419 Macapa, AP, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais, BR-09972270 Diadema, SP, BrazilUniv Fed Fluminense, Fac Farm, Dept Tecnol Farmaceut, BR-24241002 Niteroi, RJ, BrazilUniv Antilles Guyane,
Bereau, Didier, Machado, Leandro, Perazzo, Fabio Ferreira, Tavares Carvalho, Jose Carlos   +3 more
core   +2 more sources