Results 31 to 40 of about 3,248 (213)
Harmaline-Induced Tremor in Mice: Videotape Documentation and Open Questions About the Model
Tremor and Other Hyperkinetic Movements, 2013 Background: Harmaline‐induced tremor in rodents has been extensively used as an animal model for essential tremor (ET). However, there is no visual documentation in the published literature.Methods: We injected mice subcutaneously with either 20 mg/kg of
Melody M. Cheng +2 more
doaj +1 more source
Changes in the Soil Fungal Community Mediated by a Peganum harmala Allelochemical
Frontiers in Microbiology, 2022 Plants can release phytotoxic allelochemicals into the environment, not only to suppress other plants’ growth, but also alter community structure of soil microbiota, however, the mechanism are often complicated.
Kai Shi, Kai Shi, Hua Shao, Hua Shao
doaj +1 more source
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]
, 2016 Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc +12 more
core +3 more sources
Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2020 We report the design, synthesis, and evaluation of a series of harmaline analogs as selective inhibitors of 2-arachidonylglycerol (2-AG) oxygenation over arachidonic acid (AA) oxygenation by purified cyclooxygenase-2 (COX-2). A fused tricyclic harmaline analog containing a CH3O substituent at C-6 and a CH3 group at the C-1 position of 4,9-dihydro-3H ...
Md. Jashim Uddin +6 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2016 We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia.
Xi-Ling Jiang +4 more
doaj +1 more source
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
, 2018 Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core +1 more source
Frontiers in Pharmacology, 2017 Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li +10 more
doaj +1 more source
Seasonal changes in antioxidative/oxidative profile of mining and non-mining populations of Syrian beancaper as determined by soil conditions [PDF]
, 2017 Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed.
Bueso Sánchez, María del Carmen +4 more
core +2 more sources
Harnessing Pharmacogenomics in Clinical Research on Psychedelic-Assisted Therapy. [PDF]
Clin Pharmacol TherPsychedelics have recently re‐emerged as potential treatments for various psychiatric conditions that impose major public health costs and for which current treatment options have limited efficacy. At the same time, personalized medicine is increasingly being implemented in psychiatry to provide individualized drug dosing recommendations based on ...
Halman A +5 more
europepmc +2 more sources
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor [PDF]
, 2008 Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors likely play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin.
Factor-Litvak, Pam +6 more
core +2 more sources