Results 11 to 20 of about 3,248 (213)

Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways [PDF]

Brain and Behavior
Purpose Essential tremor (ET) is a prevalent movement disorder, yet current therapeutic options remain limited. Emerging evidence implicates leucine‐rich repeat and immunoglobulin‐like domain‐containing protein (Lingo‐1) and neuroinflammation in the ...
Zeynab Pirmoradi, Zahra Esmaili, Mohsen Nakhaie, Kristi A. Kohlmeier, Mohammad Shabani, Moazamehosadat Razavinasab, Mehran Ilaghi   +6 more
doaj   +3 more sources

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor [PDF]

Tremor and Other Hyperkinetic Movements, 2012
Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature.
Adrian Handforth
doaj   +5 more sources

Riluzole Ameliorates Harmaline-Induced Tremor in Rat

Basic and Clinical Neuroscience, 2014
Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor.
Fatemeh Rahimi Shourmasti, Iran Goudarzi, Kataneh Abrari, Mahmoud Elahdadi Salmani, Taghi Lashkarboluki   +4 more
doaj   +2 more sources

Role of Harmaline in Inhibiting c-Myc, Altering Molecular Typing, and Promoting Apoptosis in Triple-Negative Breast Cancer [PDF]

Breast Cancer: Targets and Therapy
Haoyi Xu,1 Yan Ma,2 Huiling Li,1 Xinyu Song,1 Yuanjing Liu,1 Zuliyaer Mierzhakenmu,1 Kang Yan,1 Rui Xu,1 Ziqian Zhao,1 Hongyi Yuan,1 Chao Dong1 1Department of Breast and Thyroid Surgery, the Third Clinical Medical College of Xinjiang Medical University ...
Xu H, Ma Y, Li H, Song X, Liu Y, Mierzhakenmu Z, Yan K, Xu R, Zhao Z, Yuan H, Dong C   +10 more
doaj   +2 more sources

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment [PDF]

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +2 more sources

Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits [PDF]

Scientific Reports
Essential tremor (ET) is a neurological disease that impairs motor and cognitive functioning. A variant of the Lingo-1 genetic locus is associated with a heightened ET risk, and increased expression of cerebellar Lingo-1. Lingo-1 has been associated with
Zeynab Pirmoradi, Mohsen Nakhaie, Hoda Ranjbar, Davood Kalantar-Neyestanaki, Kristi A. Kohlmeier, Majid Asadi-Shekaari, Amin Hassanshahi, Mohammad Shabani   +7 more
doaj   +2 more sources

Vagus Nerve Stimulation in Movement Disorders, from Principles to a Systematic Review of Evidence. [PDF]

Mov Disord
Abstract Background The vagus nerve (VN), the principal component of the parasympathetic branch of the autonomic nervous system (ANS), mediates bidirec communication between the central nervous system (CNS) and peripheral organs. Vagus nerve stimulation (VNS), delivered through invasive (iVNS) or non‐invasive (transcutaneous cervical [tcVNS] and ...
Proietti F, Ottaviani MM, Burchi E, Vivacqua G, Anzini G, Ricciuti RA, Capone F, Macefield VG, Di Lazzaro V, Marano M.   +9 more
europepmc   +2 more sources

Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study

Sensors, 2023
Functional ultrasound (fUS), an emerging hemodynamic-based functional neuroimaging technique, is especially suited to probe brain activity and primarily used in animal models.
Rohit Nayak, Jeyeon Lee, Setayesh Sotoudehnia, Su-Youne Chang, Mostafa Fatemi, Azra Alizad   +5 more
doaj   +1 more source

Olfacto-protective roles of Nigella sativa oil in Harmaline-induced essential tremor modelling

Annals of Health Research, 2020
Background: Harmaline is a tremorgenic beta-carboline, reported to induce acute postural and kinetic tremor. Essential Tremor (ET) is an idiopathic slowly neurodegenerative tremor disorder which also compromises olfactory acuity. Nigella sativa (NS) is a
R Folarin, S John, O Oyenuga, N Tijani, O Otulana, E Mbonu   +5 more
doaj   +1 more source

Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye

Biomedicines, 2022
Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N’N-dimethyltryptamine (DMT) were investigated.
Anna Szilágyi, Barbara Takács, Réka Szekeres, Vera Tarjányi, Mariann Bombicz, Dániel Priksz, Attila Kovács, Béla Juhász, Ede Frecska, Zoltán Szilvássy, Balázs Varga   +10 more
doaj   +1 more source