Results 1 to 10 of about 1,455 (150)

Quercetin nanoemulsion ameliorates tremor and neuroinflammatory dysregulation: behavioral and molecular insights in a mouse model of essential tremor [PDF]

Behavioral and Brain Functions
Background Essential tremor (ET) is a common movement disorder characterized by persistent limb tremors. Currently, no effective treatment for ET exists.
Zeynab Pirmoradi, Monavareh Soti, Kristi A. Kohlmeier, Mohammad Shabani, Fatemeh Shahsavari   +4 more
doaj   +2 more sources

Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways [PDF]

BMC Neuroscience
Introduction Essential tremor (ET) is a common neurodegenerative disorder characterized by action tremors and various non-motor symptoms. This study investigated the potential therapeutic effects of ketamine, an NMDA receptor antagonist with known GABA ...
Mehran Ilaghi, Zeynab Pirmoradi, Zahra Esmaili, Shamim Hosseinalipour, Leili Rouhi, Adel Soltanizadeh, Mohsen Nakhaie, Kiana Sharififar, Moazamehosadat Razavinasab, Mohammad Shabani   +9 more
doaj   +2 more sources

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]

Frontiers in Pharmacology
BackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco, Tiago Nicoliche, Nelson Francisco Corrêa-Neto, Rafael Lanaro, Ariadiny L. Caetano, Carla Maximo Prado, Rodrigo Portes Ureshino, Rodrigo Portes Ureshino, Iolanda de Fátima Lopes Calvo Tibério, Renato Fraga Righetti, Renato Fraga Righetti, Roberta Sessa Stilhano, Alessandra Linardi   +12 more
doaj   +2 more sources

Dose-dependent antiviral effects of glycyrrhizin, curcumin, and harmaline against clinical SARS-CoV-2 isolates, including D614G, Omicron BA.5, and Omicron XBB.1 [PDF]

BMC Complementary Medicine and Therapies
Background SARS-CoV-2 remains a major global health challenge, as infection can lead to potential life-threatening conditions such as COVID-19. Emerging variants of the virus are characterized by higher transmission rates and immune escape mutations ...
Rabea Grüneberg, Isabel Zydek, Carina Elsner, Evelyn Scheiermann, Ulf Dittmer, Folker Meyer, Ivana Kraiselburd, Hana Rohn, Oliver Witzke, Laura Thümmler, Adalbert Krawczyk   +10 more
doaj   +2 more sources

Bridging the Knowledge Gap in Harmaline’s Pharmacological Properties: A Focus on Thermodynamics and Kinetics [PDF]

Pharmaceutics
Background/Objectives: Advancing information on the key physicochemical properties of biologically active substances enables the development of formulations with reduced dosing, lower toxicity, and minimal adverse effects.
Tatyana Volkova, Olga Simonova, German Perlovich   +2 more
doaj   +2 more sources

Harmaline induces apoptosis and inhibits migration in A2780 ovarian cancer cells in vitro [PDF]

Physiological Reports
Ovarian cancer is one of the most prevalent malignancies in women. Harmaline is reported to have powerful anticancer properties. We aimed to investigate the apoptotic and antimetastatic properties of harmaline in A2780 ovarian cancer cells.
Seyed Ali Shariat Razavi, Masoumeh Taghdisi Khaboushan, Raha Jafari, Arshia Shahini, Gordon A. Ferns, Afsane Bahrami   +5 more
doaj   +2 more sources

Development of Harmaline-induced Tremor in a Swine Model

Tremor and Other Hyperkinetic Movements, 2018
Background: In the field of translational neuroscience research, it is critical to utilize a large animal model to test the feasibility, safety, and functionality of novel therapies.
Jihyun Lee, Inyong Kim, Jeyeon Lee, Emily Knight, Lei Cheng, Shin il Kang, Dong Pyo Jang, Su-Youne Chang   +7 more
doaj   +5 more sources

Investigation of β-Carboline Alkaloid Harmaline Against Cyvirus cyprinidallo3 Infection In Vitro and In Vivo [PDF]

Viruses
Cyvirus cyprinidallo3, also known as Cyprinid herpesvirus 3 (CyHV-3), is a common pathogen of koi and common carp (Cyprinus carpio). Infection of CyHV-3 can lead to high mortality in fry under 4 months of age.
Clement Manes, Kristen Larson, Shelby Matsuoka, Xisheng Wang, Ruth Milston-Clements, Ling Jin   +5 more
doaj   +2 more sources

In vitro anti-parasitic effect of the alkaloids harmaline and piperine on Toxoplasma gondii [PDF]

Revista Brasileira de Parasitologia Veterinária
Toxoplasma gondii is a coccidian protozoan of zoonotic importance that causes toxoplasmosis. Although the current treatments for toxoplasmosis may be associated with adverse effects and limited efficacy for different biological forms of the parasite ...
Daniele Silva Souza Carreira, Carolina Emy Sato, Waléria Borges da Silva, Thereza Cristina Borio dos Santos Calmon de Bittencourt, Silvia Lima Costa, Rosângela Soares Uzêda   +5 more
doaj   +2 more sources

Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections [PDF]

Microbial Cell Factories
Background A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last ...
Jindian Yang#, Lei Xu#, Yonglin Zhou, Minhe Cui, Dejun Liu, Jianfeng Wang, Yang Wang, Xuming Deng   +7 more
doaj   +2 more sources