Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways [PDF]
Brain and BehaviorPurpose Essential tremor (ET) is a prevalent movement disorder, yet current therapeutic options remain limited. Emerging evidence implicates leucine‐rich repeat and immunoglobulin‐like domain‐containing protein (Lingo‐1) and neuroinflammation in the ...
Zeynab Pirmoradi +6 more
doaj +2 more sources
Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice [PDF]
Iranian Journal of Basic Medical Sciences, 2015 Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus ...
Bahareh Amin +3 more
doaj +3 more sources
Minocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline [PDF]
Basic and Clinical Neuroscience, 2021 Introduction: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis ...
Marzieh Maneshian +5 more
doaj +2 more sources
Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease. [PDF]
J PhysiolAbstract figure legend Cerebellar dysfunction can give rise to various movement disorders. Misfiring cerebellar neurons often underlie this dysfunction. Because Purkinje cells form inhibitory synapses onto cerebellar nuclei cells, it has been presumed that spike activity changes in Purkinje cells cause inverse spike activity changes in the downstream ...
Lyon AM +2 more
europepmc +2 more sources
Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits [PDF]
Scientific ReportsEssential tremor (ET) is a neurological disease that impairs motor and cognitive functioning. A variant of the Lingo-1 genetic locus is associated with a heightened ET risk, and increased expression of cerebellar Lingo-1. Lingo-1 has been associated with
Zeynab Pirmoradi +7 more
doaj +2 more sources
Sensors, 2023 Functional ultrasound (fUS), an emerging hemodynamic-based functional neuroimaging technique, is especially suited to probe brain activity and primarily used in animal models.
Rohit Nayak +5 more
doaj +1 more source
Über Harmalin‐Abkömmlinge [PDF]
Berichte der deutschen chemischen Gesellschaft, 1912 n ...
Fischer, Otto, Boesler, Walter
openaire +1 more source
Agmatine has beneficial effect on harmaline-induced essential tremor in rat [PDF]
, 2021 Essential tremor (ET) is one of the most prevalent movement disorders and the most common cause of abnormal tremors. However, it cannot be treated efficiently with the currently available pharmacotherapy options.
Ateş, Nurbay +5 more
core +3 more sources
Image_1_Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor.TIF [PDF]
, 2022 Essential Tremor (ET) is a common movement disorder, characterised by a posture or movement-related tremor of the upper limbs. Abnormalities within cerebellar circuits are thought to underlie the pathogenesis of ET, resulting in aberrant synchronous ...
Richard Apps (531616) +3 more
core +1 more source
Olfacto-protective roles of Nigella sativa oil in Harmaline-induced essential tremor modelling
Annals of Health Research, 2020 Background: Harmaline is a tremorgenic beta-carboline, reported to induce acute postural and kinetic tremor. Essential Tremor (ET) is an idiopathic slowly neurodegenerative tremor disorder which also compromises olfactory acuity. Nigella sativa (NS) is a
R Folarin +5 more
doaj +1 more source