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Pharmacological effects of harmine and its derivatives: a review
Archives of Pharmacal Research, 2020Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has been used for thousands of years in the Middle East and China. Harmine has many pharmacological activities including anti-inflammatory, neuroprotective, antidiabetic, and antitumor activities.
Liang, Zhang +2 more
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Pharmacokinetics in the rat of the hallucinogenic alkaloids harmine and harmaline
Naunyn-Schmiedeberg's Archives of Pharmacology, 19741. After i. v. injection in rats, harmine and harmaline were distributed in the organism within a few seconds. In spite of the close chemical relationship, both alkaloids revealed significant pharmacokinetic differences. 2. Highest concentrations occurred for harmine in the lung and for harmaline in the kidney.
Zetler G, G Zetler
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2022
Basic research project with rodents. Rodents were administerred DMT and/or harmine and to investigate effects on 5HT2A receptor occupancy of DMT, changes in FDG uptake and brain concentrations of DMT, harmine and their metabolites. This work is published at Frontiers in Pharmacology (DOI: 10.3389/fphar.2023.1140656).
Scheidegger, Milan +2 more
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Basic research project with rodents. Rodents were administerred DMT and/or harmine and to investigate effects on 5HT2A receptor occupancy of DMT, changes in FDG uptake and brain concentrations of DMT, harmine and their metabolites. This work is published at Frontiers in Pharmacology (DOI: 10.3389/fphar.2023.1140656).
Scheidegger, Milan +2 more
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Effects of tremorine and harmine in the chick
European Journal of Pharmacology, 1967Abstract Tremorine produced pronounced tremor, akinesia, hypothermia and parasympathetic effects in young chicks. Tremor was recorded quantitatively and the tremor response to tremorine was found to diminish with increasing age and with repeated dosage.
W C, Bowman, G, Osuide
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Harmine Action in Rats with Lymphostatic Encephalopathy
Pharmacology, 2008In rats with lymphostatic encephalopathy the duration of harmine tremor was lengthened, and the brain concentrations of harmine decreased more slowly than in sham-operated controls. The tremor began simultaneously in both rat groups at coinciding brain concentrations of harmine.
G, Back, G, Seidel
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An investigation of the tremorgenic actions of harmine in the rat
European Journal of Pharmacology, 1971Abstract Antagonism of harmine tremor by drugs which interfere with adrenergic nervous function was investigated in rats. Reserpine, diethyldithiocarbamic acid and propranolol reduced the intensity of the tremor without abolishing it completely. Phenoxybenzamine, mebanazine and atropine were without effect.
B, Cox, D, Potkonjak
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The Harmine Group of Alkaloids
1937Harmine and harmaline are alkaloids found in the seeds of Peganum harmala and the pharmacological actions of these alkaloids, as well as of many artifically prepared derivatives of them, have now been investigated in considerable detail. The seeds of the plant have been used therapeutically for centuries and a brief reference to this earlier history ...
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A MODEL OF HARMINE METABOLISM IN THE RAT
The Journal of Pharmacology and Experimental Therapeutics, 1970T A, Slotkin, V, DiStefano
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Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway
Life Sciences, 2021Huang Kuang, Yun-Xia Lv
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