Results 41 to 50 of about 3,945,564 (229)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Relationship between dry matter content at harvest and maturity index and post-harvest quality of ‘Fuji’ apples

open access: yesRevista Brasileira de Fruticultura, 2018
Two experiments were carried out to evaluate the relationship between dry matter content (DMC) and maturity index of ‘Fuji’ apple fruit sports (‘Mishima’, ‘Fuji Select’ and ‘Fuji Suprema’) during the final stage of fruit growth, and the relationship ...
Marcelo José Vieira   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Inheritance of harvest index in common bean

open access: yesCrop Breeding and Applied Biotechnology, 2018
The aim of this study was to verify if the harvest index (HI) of common bean is higher in modern lines, to verify if its estimate varies with the cycle of the plant and environmental conditions, and to obtain information concerning its genetic control ...
Ricardo Andrade Pinto Júnior   +3 more
doaj  

Response of Three Bread Wheat Cultivars to Different Levels of Seeding Rates in Ilam Region [PDF]

open access: yesIkufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2012
In order to study the effects of seeding rates on yield and yield components of three bread wheat cultivars, a factorial experiment based on randomized complete block design (RCBD) with 3 replications was conducted during 2006-2007, in Sarableh town ...
A. Maleki, P. Seyedan, A. Tahmasbi
doaj  

Evaluation and identification of wheat hybrids for wider adaptability

open access: yesElectronic Journal of Plant Breeding, 2017
The experimental material comprising F1, F2, BC1 and BC2 generations derived from crosses involving five parents were evaluated to find out stability in bread wheat under four environments.
Rakhi Sinha and, R.S. Shukla
doaj   +1 more source

Organic Manure Improves Soybean Response to Rhizobia Inoculant and P-Fertilizer in Northern Ghana

open access: yesFrontiers in Agronomy, 2020
Inherently low concentrations of soil nutrients and erratic rainfall pattern in sub-Sahara Africa limit soybean response to rhizobia inoculant and P-fertilizer.
Jacob Ulzen   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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