Results 131 to 140 of about 5,167 (169)

Has2 expression in heart forming regions is independent of BMP signaling

Gene Expression Patterns, 2006
Heart septation and valve malformations constitute the most common birth defects. These cardiac structures arise from the endocardial cushions through dynamic interactions between cells and the extracellular matrix (cardiac jelly). Targeted deletion of the hyaluronan synthase-2 (Has2) gene in mice results in an absence of cardiac jelly and endocardial ...
Parker B Antin, Todd Camenisch, Scott Klewer   +2 more
exaly   +3 more sources

WNT5A Enhances LH-Mediated Expression of HAS2 in Granulosa Cells

Reproductive Sciences, 2021
In adult ovary, WNT5A is involved in follicular responses to gonadotropins and necessary for ovarian follicle development. However, the mechanism by which gonadotropins regulate WNT5A and the role of WNT5A in modulating follicular responses to gonadotropins are unclear.
Qun Niu, Jingjing Shi, Qing Gao, Jiang Fu   +3 more
openaire   +2 more sources

MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2

Endocrine, 2023
The aim of this study was to investigate the microRNA (miRNA) expression profile in peripheral blood mononuclear cells (PBMC) of thyroid-associated ophthalmopathy (TAO) patients and to explore the molecular mechanisms of MicroRNA-376b (miR-376b) in the pathogenesis of TAO.PBMCs from TAO patients and healthy controls were analyzed by miRNA microarray to
Rongjiao Liu, Zhengqin Ye, Qi Liu, Miao Xuan, Ran Li, Liya Zhang, Keqin Zhang, Ping Fang, Ying Xue   +8 more
openaire   +2 more sources

HAS2 and CD44 in Breast Tumorigenesis

2014
Metastatic spread of breast cancer cells, facilitated by the epithelial-mesenchymal transition (EMT) process, is responsible for the majority of breast cancer mortality. Increased levels of hyaluronan due to deregulation of hyaluronan-synthesizing enzymes, like HAS2, and expression of CD44, the key receptor for hyaluronan, are correlated to poor ...
Heldin P, Basu K, Kozlova I, Porsch H
openaire   +3 more sources

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Matrix Biology, 2019
The glycosaminoglycan hyaluronan has a crucial role in tissue organization and cell signaling. Hyaluronan accumulates in conjunction with rapid tissue remodeling during embryogenesis, as well as in inflammatory conditions and cancer. We report a negative correlation between the expression of genes encoding hyaluronan synthase HAS2, its natural ...
Constantinos Kolliopoulos, Chun-Yu Lin, Carl-Henrik Heldin, Aristidis Moustakas, Paraskevi Heldin   +4 more
openaire   +2 more sources

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

Nature, 2023
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent-the naked mole-rat1,2. To study whether the benefits of HMM-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene ...
Zhihui Zhang, Xiao Tian, J. Yuyang Lu, Kathryn Boit, Julia Ablaeva, Frances Tolibzoda Zakusilo, Stephan Emmrich, Denis Firsanov, Elena Rydkina, Seyed Ali Biashad, Quan Lu, Alexander Tyshkovskiy, Vadim N. Gladyshev, Steve Horvath, Andrei Seluanov, Vera Gorbunova   +15 more
openaire   +2 more sources

The Role of Hyaluronan Produced by Has2 Gene Expression in Development of the Spine

Spine, 2011
Histologic analysis of spine development in cartilage-specific knockout mice.To evaluate the role hyaluronan produced by hyaluronan synthase-2 (Has2) in spine development.The Has2 gene is responsible for most hyaluronan production throughout the body, including the skeleton. However, it is not possible to study the involvement of hyaluronan in skeletal
Peter J, Roughley, Lisa, Lamplugh, Eunice R, Lee, Kazu, Matsumoto, Yu, Yamaguchi   +4 more
openaire   +2 more sources

Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis

Matrix Biology, 2020
Hyaluronan plays a key role in regulating inflammation and tumor angiogenesis. Of the three transmembrane hyaluronan synthases, HAS2 is the main pro-angiogenic enzyme responsible for excessive hyaluronan production. We discovered that HAS2 was degraded in vascular endothelial cells via autophagy evoked by nutrient deprivation, mTOR inhibition, or pro ...
Carolyn G. Chen, Maria A. Gubbiotti, Aastha Kapoor, Xiaorui Han, Yanglei Yu, Robert J. Linhardt, Renato V. Iozzo   +6 more
openaire   +2 more sources

The Role of HA and Has2 in the Development and Function of the Skeleton

2013
Hyaluronan (HA) is present throughout the body, including all the bones and cartilages of the skeleton, where it may fulfill both a structural and metabolic role depending on its molecular size. In mammals, HA is produced by three hyaluronan synthases (Has), of which Has2 is the predominant form in cartilage and bone.
Peter J. Roughley, Pierre Moffatt
openaire   +1 more source

Cx40, HAS2 und ADAMTS1

2012
Das Endothel, eine einschichtige Zelldecke, ist als innerste Auskleidung von Blutgefäßen direkt dem strömenden Blut ausgesetzt. Sein Funktionszustand wird neben anderen biochemischen und mechanischen Einflüssen durch Wandschubspannung moduliert. Diese ist je nach Lokalisation im Gefäßnetz unterschiedlich: an Prädilektionsstellen für Atherosklerose ...
openaire   +1 more source