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Curcumin Effect on HAS2 Gene Expression on Senescent Fibroblasts
2021People's lifestyle, the environment they live in and the products they use cause changes in their gene expression. Changes in living conditions have a direct impact on the body. One of the most affected processes is the aging process. In our research we examined the effect of curcumin in the aging process of human skin fibroblasts.
Neziri, Sabina +2 more
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Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice
2023Abstract Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat 1, 2 . To study whether the benefits of HMW-HA could be transferred to other animal species, we generated a ...
Zhihui Zhang +15 more
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In Vitro Cellular & Developmental Biology - Animal, 2013
Triiodothyronine (T3) is a thyroid hormone that can have varying effects on skin. In order to assess the effects of T3 on the human dermis, we prepared dermal equivalents using neonatal dermal cells via the process of self-assembly in the presence of differing concentrations of T3.
Tara, Pouyani +3 more
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Triiodothyronine (T3) is a thyroid hormone that can have varying effects on skin. In order to assess the effects of T3 on the human dermis, we prepared dermal equivalents using neonatal dermal cells via the process of self-assembly in the presence of differing concentrations of T3.
Tara, Pouyani +3 more
openaire +2 more sources
The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer
Experimental Cell Research, 2005Within tumors there appears to be an intricate balance between hyaluronan (HA) synthesis and degradation where the invading edges display increased HA metabolism. The metabolism of HA has not been characterized in breast cancer cell lines; therefore, this study quantitatively identifies and characterizes the enzymes responsible for the synthesis and ...
Lishanthi, Udabage +3 more
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Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc
Cellular SignallingGlioblastoma multiforme (GBM) is the most common and aggressive primary malignant human brain tumor. Although comprehensive therapies, including chemotherapy and radiotherapy following surgery, have shown promise in prolonging survival, the prognosis for GBM patients remains poor, with an overall survival rate of only 14.6 months.
Juling, Wang +13 more
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MicroRNA-ITGA6/ Has2 signaling regulates liver fibrosis
Zeitschrift für Gastroenterologie, 2023Rajendra Khanal +6 more
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The Role of Has2 in a Papain-induced Asthma-COPD Overlap Mouse Model
American Journal of Respiratory and Critical Care MedicineAbstract Rationale: Asthma and COPD overlap (ACO) is a complex clinical disorder that combines features of both asthma and COPD. It is characterized by chronic airway inflammation, airway hyperresponsiveness, and airflow limitation, but its pathogenesis remains poorly understood.
Z. Wei +10 more
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The role of Has2 on long bone development
Matrix Biology, 2008Peter J. Roughley +3 more
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TGF‐β/SMAD4 signaling pathway activates the HAS2–HA system to regulate granulosa cell state
Journal of Cellular Physiology, 2020Xing Du, Qifa Li
exaly
Has2 deficiency enhances OVA‐induced airway inflammation and hyperresponsiveness in mice
Allergy, 2021Yoshiya Tsunoda +10 more
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