Results 241 to 250 of about 1,470,445 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Replacing Dietary Roughage with Barley Hay Affects Rumen Fermentation, Microbial Community, Serum Immune and Antioxidant Status in Sheep. [PDF]

Animals (Basel)
Wang X, Liu X, Hai L, Han G, Erdene K, Bai C, Cao Q, Zheng Y, Liu Z, Ao C.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Passport to the Profession: Standards-Based Portfolios [PDF]

, 2005
White, Julie, Hay, T
core  

Amaranth as a sustainable feed resource for livestock. [PDF]

Vet Anim Sci
Katiyatiya CLF, Ncanywa T.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Feeding different proportion of oat silage in feedlot diets: effects on rumen function and meat quality of Tibetan sheep. [PDF]

AMB Express
Zhang X, Sa R, Gao W, Zhang Y, Han L, Hou S, Luo Z, Gui L.   +7 more
europepmc   +1 more source

Evaluation of forage production performance and prediction of introduction adaptability for different <i>Avena sativa</i> germplasms in the southeast edge of the Qinghai-Tibet plateau. [PDF]

Front Plant Sci
Zhao T, Lu H, Zhang F, Zheng Y, Tang L, Zhang C, Ma Y, Cai R, Xie W.   +8 more
europepmc   +1 more source

Lactation performance of Holstein dairy cows fed diets with or without an annual forage mix silage. [PDF]

Transl Anim Sci
Akins MS, Gumus H, Ferraretto LF.
europepmc   +1 more source

The Effect of Photoperiod on the Profile of Prolactin, Leptin, Insulin and the Content of Bioactive Substances in Sheep Milk During the Rearing Period of Lambs. [PDF]

Animals (Basel)
Flis Z, Marciniak E, Misztal T, Matusevičius P, Sady M, Molik E.   +5 more
europepmc   +1 more source