Results 51 to 60 of about 15,946 (160)

A Predictive Model to Evaluate the HbeAg Positivity of Chronic Hepatitis B Virus Patients in Clinics: A Cross-Sectional Study

Medicina, 2022
Background and Objective: The study aims to investigate the correlation between Hepatitis B ‘e’ antigen (HBeAg) and HBV DNA levels, and to find a convenient tool to estimate the HBV DNA level for clinicians.
Ning Wang, Jinli Zheng, Yang Huang, Xingyu Pu, Li Jiang, Jiayin Yang   +5 more
doaj   +1 more source

Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh

Journal of Acute Disease, 2013
AbstractObjectiveTo compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV.MethodsWe did percutaneous liver biopsies of 155 CHB patients.
Ayub Al Mamun, Mamun-Al-Mahtab, S.M. Fazle Akbar, Kutub Uddin Mollick, Arun Jyoti Tarafdar, Faiz Ahmad Khondokar, Ahmed Lutful Mubin, Md. Helal Uddin, Salimur Rahman   +8 more
openaire   +2 more sources

Vaccines at the Heart of Hepatitis Elimination: Insights From the ESCMID Study Group for Viral Hepatitis (ESGVH)

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention ...
Oana Săndulescu, Gülşen Özkaya Şahin, Susanne Gjeruldsen Dudman, Zeinab Nabil Ahmed Said, Mario U. Mondelli, on behalf of ESCMID Study Group for Viral Hepatitis (ESGVH)   +5 more
wiley   +1 more source

Prevalence and clinical significance of HBeAg-positive chronic hepatitis B patients with and without anti-HBe antibody

Virulence
The clinical significance of the coexistence of hepatitis B e antigen (HBeAg) and antibodies against HBeAg (anti-HBe) in patients with chronic hepatitis B (CHB) remains unclear.
Ruifei Xue, Jian Wang, Jie Zhan, Zhiyi Zhang, Suling Jiang, Jiacheng Liu, Li Wang, Xiaomin Yan, Shengxia Yin, Xin Tong, Weimao Ding, Jie Li, Yuxin Chen, Rui Huang, Chao Wu   +14 more
doaj   +1 more source

Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi

BMC Infectious Diseases, 2021
Background The World Health Organization (WHO) has targeted a reduction in viral hepatitis-related mortality by 65% and incidence by 90% by 2030, necessitating enhanced hepatitis B treatment and prevention programmes in low- and middle-income countries ...
Alexander J. Stockdale, Niza M. Silungwe, Isaac Thom Shawa, Benno Kreuels, Melita A. Gordon, Anna Maria Geretti   +5 more
doaj   +1 more source

A Systematic Review and Narrative Synthesis of Factors Impacting Late Diagnosis of Chronic Hepatitis B and C

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Late diagnosis of chronic hepatitis B and C, often identified by the presence of advanced disease such as hepatocellular carcinoma or decompensated cirrhosis at the time of initial hepatitis diagnosis, is associated with high rates of hospitalization and mortality.
Maria Ibegu, Tshiamo Keakabetse, Anh Le Tuan Nguyen, Nicola Stephens, Barbara de Graaff   +4 more
wiley   +1 more source

Clinical application of estimating hepatitis B virus quasispecies complexity by massive sequencing: correlation between natural evolution and on-treatment evolution.

PLoS ONE, 2014
AimTo evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment.MethodsUltra-deep pyrosequencing of HBV preCore/Core regions ...
Maria Homs, Andrea Caballero, Josep Gregori, David Tabernero, Josep Quer, Leonardo Nieto, Rafael Esteban, Maria Buti, Francisco Rodriguez-Frias   +8 more
doaj   +1 more source

HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis

BMC Medicine, 2021
Background We and others have confirmed activation of macrophages plays a critical role in liver injury and fibrogenesis during HBV infection. And we have also proved HBeAg can obviously induce the production of macrophage inflammatory cytokines compared
Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi, Qiang Zhu   +10 more
doaj   +1 more source

Impact of Metabolic Associated Steatotic Liver Disease on Antiviral Therapy Outcomes on Chronic Hepatitis B Patients Receiving Antiviral Therapy

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Background and Aim Chronic hepatitis B (CHB) affects over 250 million people globally and is a major contributor to liver complications, including cirrhosis and hepatocellular carcinoma (HCC). Though antiviral therapies suppress HBV, the rising prevalence of metabolic‐associated steatotic liver disease (MASLD) poses new challenges.
Sheng‐Jie Shiue, Tung‐Han Ho, Hsin‐Yi Lin, Sheng‐Wei Cheng, Li‐Wei Wu, Tze‐Sian Chan, Chun‐Nan Chen, Chao‐Ling Cheng, Yan Kang Lee, Hsien‐Yao Yang, Han‐Shiang Shiue, Kuo‐Feng Leng, Ming‐Shun Wu   +12 more
wiley   +1 more source

Advances in Rapid Nucleic Acid Diagnostics for Hepatitis B and C Viruses: A Comprehensive Review

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Chronic viral hepatitis, predominantly caused by HBV and HCV infections, remains a major global health burden and a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and liver‐related mortality. Achieving the World Health Organisation (WHO) target of diagnosing 90% of HBV and HCV infections by 2030 necessitates a fundamental ...
Hsin‐Ying Ho, Chia‐Yen Dai, I‐Jung Feng, Yen‐Hsu Chen, Ming‐Lung Yu, Che‐Hsin Lin, Ling‐Shan Yu   +6 more
wiley   +1 more source