Results 61 to 70 of about 15,946 (160)

Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA

Viruses
Full-length hepatitis B virus (HBV) transcripts of chimpanzees and patients treated with multidose (MD) HBV siRNA ARC-520 and entecavir (ETV) were characterized by single-molecule real-time (SMRT) sequencing, identifying multiple types of transcripts ...
Christine I. Wooddell, Dean Sanders, Zhao Xu, Lung-Yi Mak, Thomas Schluep, Wai-Kay Seto, Bruce D. Given, Man-Fung Yuen   +7 more
doaj   +1 more source

Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

PLoS ONE, 2015
To describe the Hepatitis B e antigen(HBeAg) seroconversion related mutation profiles of the basal core promoter(BCP)/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 ...
Yong Huang, Haijun Deng, Xuefeng Shan, Xuyang Gong, Xiaosong Li, Zen Tu, Quanxin Long, Ailong Huang   +7 more
doaj   +1 more source

Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection. [PDF]

PLoS Pathogens, 2019
Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are known to play a critical role in impairing antiviral T cell responses, viral ...
Feifei Yang, Xueping Yu, Chenliang Zhou, Richeng Mao, Mengqi Zhu, Haoxiang Zhu, Zhenxuan Ma, Bidisha Mitra, Gan Zhao, Yuxian Huang, Haitao Guo, Bin Wang, Jiming Zhang   +12 more
doaj   +1 more source

Improved Safety of Nucleic Acid Amplification Technology Combined With Serological Tests for Screening Blood Donors: A Systematic Review and Meta‐Analysis

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT No laboratory test performed to date provides an absolute guarantee for detecting infectious agents. Nucleic acid amplification techniques/tests (NAT) associated with serological tests can increase safety and provide greater diagnostic accuracy for patients. We investigated the added safety of NAT technology combined with serological tests for
Heloise Skiavine Madeira, Aline Ávila Brustolin, Marcos Elias da Silva Almeida, Maiara Vanusa Guedes Ribeiro, Raul Gomes Aguera, Fernando Américo Jorge, Luciana Dias Ghiraldi, Débora de Castro Moreira, Maria Valdrinez Campana Lonardoni, Dennis Armando Bertolini, Leyde Daiane de Peder, Claudinei Mesquita da Silva, Daniele Stéfanie Sara Lopes Lera‐Nonose, Áquila Carolina Fernandes Herculano Ramos‐Milaré, Jorge Juarez Vieira Teixeira   +14 more
wiley   +1 more source

Lack of association between early on-treatment HBeAg seroclearance and development of hepatocellular carcinoma or decompensated cirrhosis

JHEP Reports
Background & Aims: The association between hepatitis B envelope antigen (HBeAg) seroclearance during long-term nucleos(t)ide analogue (NA) treatment and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) remains ...
Hyunjae Shin, Won-Mook Choi, Seung Up Kim, Yunmi Ko, Youngsu Park, Jeayeon Park, Moon Haeng Hur, Min Kyung Park, Yun Bin Lee, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee, Fabien Zoulim   +12 more
doaj   +1 more source

Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels

Indian Journal of Pathology and Microbiology, 2011
Background: Hepatitis B virus (HBV) is a potentially life-threatening liver infection which may progress to liver failure and cirrhosis. Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications ...
Aysegul Sari, Yelda Dere, Betul Pakoz, Aylin Calli, Belkis Unal, Mine Tunakan   +5 more
doaj   +1 more source

Novel Long‐Read Sequencing Method for Characterisation of Hepatitis B Transcripts Show High Expression of Chimeric HBV/Human RNA

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background Hepatitis B virus (HBV) genomes integrated into human DNA significantly contribute to surface antigen (HBsAg) production and may drive hepatocellular carcinoma (HCC). Long‐read sequencing methods like Nanopore offer advantages over short‐read next‐generation sequencing (NGS) by providing continuous reads of whole transcripts, but ...
Joakim Bedner Stenbäck, Johan Ringlander, Maria Andersson, Jakob Holm Dalsgaard Thomsen, Sanna Abrahamsson, Gustaf E. Rydell, Magnus Lindh   +6 more
wiley   +1 more source

Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α

Therapeutic Advances in Gastroenterology
Background: As an uncommon serological pattern, the effect of hepatitis B e antigen/anti-hepatitis B e (HBeAg/anti-HBe) coexistence on peginterferon-α (Peg-IFN-α) therapy in patients with chronic hepatitis B (CHB) remains unknown.
Kaimin Song, Huitong Wang, Dawu Zeng, Yunyun Qian, Zhixiang Guo, Huatang Zhang, Yijuan Zheng, Yongjun Zhou, Xueping Yu, Zhijun Su   +9 more
doaj   +1 more source

Changes in the Prevalence of HBsAg and HBeAg: a Study of 8696 Parturients in a Well Vaccinated Area

Scientific Reports, 2017
To elucidate the impact of a hepatitis B (HB) vaccination program on the prevalence of HB surface antigen (HBsAg) and HB envelope antigen (HBeAg) as well as the success rate of HBeAg clearance among parturients, we collected data on parturients who gave ...
Chen-Hsuan Wu, Te-Yao Hsu, Fu-Tsai Kung, Chan-Chao ChangChien, Ching-Chang Tsai, Sheng-Nan Lu   +5 more
doaj   +1 more source

Efficacy and safety of long term entecavir in chronic hepatitis B treatment naïve patients in clinical practice

Annals of Hepatology, 2014
Background and aims. Entecavir (ETV) is effective and safe in patients with chronic hepatitis B in the short term, but its long term efficacy and safety has not been established.Material and methods.
Ezequiel Ridruejo, Sebastián Marciano, Omar Galdame, María V. Reggiardo, Alberto E. Muñoz, Raúl Adrover, Daniel Cocozzella, Nora Fernandez, Claudio Estepo, Manuel Mendizabal, Gustavo A. Romero, Diana Levi, Teresa Schroder, Silvia Paz, Hugo Fainboim, Oscar G. Mandó, Adrián C. Gadano, Marcelo O. Silva   +17 more
doaj   +1 more source