Results 51 to 60 of about 49,566 (218)

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources

Whole genome deep sequencing analysis of viral quasispecies diversity and evolution in HBeAg seroconverters

JHEP Reports, 2021
Summary: Background & Aims: We aimed to investigate how viral quasispecies of the HBV whole genome evolves and diversifies in response to HBeAg seroconversion and viral control utilising next-generation sequencing (NGS).
Su-Ru Lin, Ta-Yu Yang, Cheng-Yuan Peng, You-Yu Lin, Chia-Yen Dai, Hurng-Yi Wang, Tung-Hung Su, Tai-Chung Tseng, I-Jung Liu, Huei-Ru Cheng, Yueh-Chi Shen, Fang-Yi Wu, Chun-Jen Liu, Ding-Shinn Chen, Pei-Jer Chen, Hung-Chih Yang, Jia-Horng Kao   +16 more
doaj   +1 more source

Potential mutations associated with occult hepatitis B virus status [PDF]

, 2014
Context: Occult hepatitis B virus (HBV) status (OHBS) is simply defined as the presence of HBV DNA in the liver (with or without detectable HBV DNA in the serum), in the absence of serum HBV surface antigen (HBsAg). Importance of OHBS is mostly clinical,
Besharat, S., Katoonizadeh, A., Moradi, A.   +2 more
core   +1 more source

Correlation between hepatitis B G1896A precore mutations and HBeAg in chronic HBV patients [PDF]

, 2015
Background: Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (
Adli, A.H., Karami, C., Khodabakhshi, B., Moradi, A., Tabarraei, A., Zhand, S.   +5 more
core   +1 more source

Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa.

Journal of Hepatology, 2018
BACKGROUND & AIMS To eliminate hepatitis B virus (HBV) infection, it is essential to scale up antiviral treatment through decentralized services. However, access to the conventional tools to assess treatment eligibility (liver biopsy/Fibroscan®/HBV DNA ...
Y. Shimakawa, R. Njie, G. Ndow, M. Vray, P. Mbaye, P. Bonnard, R. Sombié, J. Nana, V. Leroy, J. Bottero, P. Ingiliz, Gerrit Post, Bakary Sanneh, I. Baldeh, Penda Suso, A. Ceesay, A. Jeng, H. Njai, S. Nayagam, U. d’Alessandro, I. Chemin, M. Mendy, M. Thursz, M. Lemoine   +23 more
semanticscholar   +1 more source

Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran [PDF]

, 2014
Objective(s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC).
Bazouri, M., Ghaemi, A., Javid, N., Moradi, A., Tabarraei, A., Zhand, S.   +5 more
core   +2 more sources

Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]

, 2014
The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core   +1 more source

Immunomodulatory Function of HBeAg Related to Short-Sighted Evolution, Transmissibility, and Clinical Manifestation of Hepatitis B Virus

Frontiers in Microbiology, 2018
Hepatitis B virus (HBV) infection, a global public health problem can be asymptomatic, acute or chronic and can lead to serious consequences of infection, including cirrhosis, and hepatocellular carcinoma.
A. Kramvis, E. Kostaki, A. Hatzakis, D. Paraskevis   +3 more
semanticscholar   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Comparison of evolutionary patterns of different HBeAg status in HBV genotype B and C

Open Life Sciences, 2015
The aim of this work was to investigate the different evolutionary patterns between HBeAg(+) and HBeAg(-) status of genotype B and genotype C of Hepatitis B virus (HBV).
Cai Ying, Wu Xiaomei, Shi Yunhui, Liu Wei   +3 more
doaj   +1 more source