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Comparative effectiveness of tenofovir versus entecavir combined with peginterferon Alfa-2b for functional cure in HBeAg-negative chronic hepatitis B: a propensity score-matched analysis. [PDF]

BMC Infect Dis
Wang PP, Wu HS, Deng WJ, Wu Y, Zhang Y, Gao ZL, Mo ZS.   +6 more
europepmc   +1 more source

Association between fatty liver and risk of liver failure in patients with acute hepatitis B: a retrospective cohort study. [PDF]

Front Cell Infect Microbiol
Wang XH, Chang YN, Zhang L, Yang YL, Liang LW, Zeng Y, Zhou Z, Zhong S, Li H.   +8 more
europepmc   +1 more source

Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels

Journal of Hepatology, 2022
BACKGROUND & AIMS Nucleo(s)tide analogue (NUC) withdrawal may result in HBsAg clearance in a subset of patients, but predictors remain ill-defined. METHODS We studied predictors of HBsAg loss after NUC withdrawal in a global cohort of HBeAg negative ...
Milan J Sonneveld, Jun Yong Park, Sylvia M Brakenhoff   +2 more
exaly   +2 more sources

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Cytosolic delivery of HBsAg and enhanced cellular immunity by pH-responsive liposome

Journal of Controlled Release, 2020
It remains a major challenge to prime the cytotoxic T lymphocytes (CTLs) response for the treatment of Hepatitis B virus (HBV) infection. Inspired by an important natural biological behavior, membrane fusion, we constructed a pH-responsive nanocarrier ...
Hua Yue
exaly   +2 more sources

Mutation of the “a” Determinant of HBsAg with Discordant HBsAg Diagnostic Kits

Viral Immunology, 2004
Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclonal capture/monoclonal conjugate and
Suda, Louisirirotchanakul, Chinda, Kanoksinsombat, Apiradee, Theamboonlert, Pilaipan, Puthavatana, Chantapong, Wasi, Yong, Poovorawan   +5 more
openaire   +2 more sources

Composition of HBsAg is predictive of HBsAg loss during treatment in patients with HBeAg-positive chronic hepatitis B.

Journal of Hepatology, 2020
BACKGROUND & AIMS During treatment of chronic hepatitis B virus (HBV) infections, loss or seroconversion (SC) of the HBV surface antigen (HBsAg) is considered a functional cure. HBsAg consists of the large (LHBs), middle (MHBs), and small surface protein
M. Pfefferkorn, T. Schott, S. Böhm, D. Deichsel, C. Felkel, W. Gerlich, D. Glebe, C. Wat, V. Pavlovic, R. Heyne, T. Berg, F. van Bömmel   +11 more
semanticscholar   +1 more source

HBsAg seroclearance further reduces hepatocellular carcinoma risk after complete viral suppression with nucleos(t)ide analogues.

Journal of Hepatology, 2019
BACKGROUND & AIMS In treated patients with chronic hepatitis B (CHB) who have achieved complete viral suppression, it is unclear if functional cure as indicated by hepatitis B surface antigen (HBsAg) seroclearance confers additional clinical benefit.
T. Yip, G. Wong, H. Chan, Y. Tse, K. Lam, G. Lui, V. Wong   +6 more
semanticscholar   +1 more source

Effects of hepatitis B surface antigen (HBsAg) positivity of donors in HBsAg(+) renal transplant recipients: comparison of outcomes with HBsAg(+) and HBsAg(−) donors

Transplant Infectious Disease, 2016
AbstractAimThe aim of this study was to determine the effects of hepatitis B surface antigen (HBsAg) positivity of the donors on graft survival and liver complications in HBsAg(+) renal transplant recipients.Patients and methodA group of 55 patients who underwent renal transplantation (RTx) in our hospital between 2001 and 2012 were included in the ...
Yilmaz, V. T., Aliosmanoglu, I., Erbis, H., Ulger, B. V., Cetinkaya, R., Suleymanlar, G., Kocak, H.   +6 more
openaire   +3 more sources

Polypeptide composition of HBsag

Archives of Virology, 1977
Purified HBsag has a complex structure comprising 8 polypeptides. Some of these polypeptides are immunogenic and induce both humoral and cell-mediated immunity in guinea pigs.
E, Mineva, M, Teoharova, S, Ditzov, S, Todorov   +3 more
openaire   +2 more sources