Results 131 to 140 of about 1,221,411 (264)
HIV Medicine, EarlyView.Abstract Objectives As two‐drug HIV‐1 antiretroviral therapy (ART) regimens become standard, data gaps remain concerning their safety and efficacy among people with isolated reactive hepatitis B core antibodies (anti‐HBc). Here, we assessed the safety and efficacy of dolutegravir/lamivudine (DTG/3TC) versus three‐ or four‐drug regimens (3DRs/4DRs ...
D. Fox +10 more
wiley +1 more source
Immunology, EarlyView.This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani +16 more
wiley +1 more source
Journal of Periodontal Research, EarlyView.The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag +6 more
wiley +1 more source
The Role of Viruses in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte +2 more
wiley +1 more source
Chronic HBV patients divided into three groups based on HBV DNA and HBeAg levels.
, 2014 HBeAg levels, HBsAg levels and HBV DNA were measured in 45 chronic HBV patients. (A) HBV patients were divided into an HBeAgnegative/HBeAglow group (100 IU/ml).
Zwier M. Groothuismink (563332) +5 more
core +1 more source
Invalid Nucleic Acid Test Results May Limit Deceased Donor Organ Utilization
Transplant Infectious Disease, EarlyView.Rare instances occur in which discriminatory NAT results cannot be resolved in deceased organ donor cases. When these events occur the impact on organ donation can be substantial. ABSTRACT Background Nucleic acid testing (NAT) is essential for detecting transmissible viral infections in deceased organ donors and guiding safe organ allocation.
Sara Dionne +5 more
wiley +1 more source
Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response
Transfusion, EarlyView.Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn +14 more
wiley +1 more source
Safety and tolerability of amustaline/glutathione pathogen‐reduced red blood cells in neonatal rats
Transfusion, EarlyView.Abstract Background Amustaline (S‐303)/glutathione (GSH) pathogen‐reduced red blood cells (PR‐RBCs) are in development for all adult and pediatric RBC transfusion indications, including neonates and infants. A neonatal rat model evaluated the safety and tolerability of PR‐RBCs during growth and maturation. Study Design and Methods Repeated transfusions
Anne North +3 more
wiley +1 more source
Journal of Associated Medical Sciences, 2018 Background: in Thailand, an estimated three million people are chronically infected with hepatitis B virus (HBV), mostly with genotypes C and B. Level of HBV replication as measured by quantification of HBV DNA in blood is crucial for management of ...
Woottichai Khamduang +5 more
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