Results 131 to 140 of about 1,553,868 (271)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Investigation of HBV DNA at hbsag positive patients [PDF]

, 2016
Amaç: Hepatit B infeksiyonu kronik karaciğer hastalığı ve hepatosellüler karsinoma gelişme riski açısından önemli bir sağlık sorunu olmaya devam etmektedir.
Batı, Nihal Seçil
core  

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Hepatitis B Virus Infection Status in Japanese Children Prior to Universal Vaccination: Sustained Effectiveness of Mother‐to‐Child Transmission Prevention and Residual Infection Burden

Hepatology Research, EarlyView.
ABSTRACT Aim To evaluate the effectiveness of prevention of mother‐to‐child transmission (PMTCT) over 25 years, we conducted a nationwide epidemiological survey through a comprehensive assessment of hepatitis B virus (HBV) markers. Methods Two cohorts were recruited before universal vaccination: children aged 9–10 years undergoing school health ...
Aiko Sakai, Yasuhito Tanaka, Hiroshi Yotsuyanagi, Masaya Sugiyama, Ichiro Morioka, Kiyotaka Kosugiyama, Kimiaki Uetake, Tomohiro Katsuta, Atsushi Imamura, Tomoko Takano, Hitoshi Tajiri, Akihito Ishida, Kosuke Ushijima, Yumiko Nakashima, Hiroyuki Moriuchi, Shinji Iwane, Kota Sawada, Yosuke Shimizu, Yukari Uemura, Manabu Tagawa, Masashi Mizokami, Ryo Sumazaki   +21 more
wiley   +1 more source

Proteomic Analysis of Serum Extracellular Vesicles Revealed Fibulin‐3 as a Novel Predictive Biomarker for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

Hepatology Research, EarlyView.
We carried out proteomic analysis of serum extracellular vesicles to identify biomarkers predictive of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B receiving nucleos(t)ide analog therapy. Candidate proteins identified through proteomic analysis were subsequently quantified in serum by ELISA.
Emi Sometani, Kazuhiro Murai, Hayato Hikita, Jihyun Sung, Satoshi Muraoka, Hidenori Toyoda, Satoshi Tanaka, Takayuki Miyake, Shinji Kuriki, Kenji Fukumoto, Satoshi Shigeno, Yuta Myojin, Kazuki Maesaka, Kumiko Shirai, Yuki Makino, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Jun Adachi, Tomomi Yamada, Tetsuo Takehara   +21 more
wiley   +1 more source

HBV-DNA and Primary Immune Complex Glomerulonephritis [PDF]

Nephron, 2008
G, Rostoker, M, Vidaud, V, Wircin, M, Meignan, P, Lang, G, Lagrue, M, Goossens, B, Weil   +7 more
openaire   +2 more sources

On‐Treatment Reassessment of Type IV Collagen 7S and M2BPGi‐Qt Improves Long‐Term Hepatocellular Carcinoma Risk Stratification in Chronic Hepatitis B

Hepatology Research, EarlyView.
One‐year reassessment of type IV collagen 7S, supported by quantitative M2BPGi‐Qt assessment, helped refine long‐term hepatocellular carcinoma risk stratification in patients with chronic hepatitis B receiving nucleos(t)ide analogue therapy. On‐treatment 4COL7S emerged as a novel marker of residual fibrosis‐related HCC risk.
Kazumi Yamasaki, Hideko Kozuru, Tomoko Sato, Tomoyuki Suehiro, Yasuhide Motoyoshi, Yuki Kugiyama, Akira Saeki, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi   +9 more
wiley   +1 more source

Quantification of hepatitis B virus (HBV) DNA and HBV genotyping simultaneously in plasma using real-time polymerase chain reaction

Journal of Associated Medical Sciences, 2018
Background: in Thailand, an estimated three million people are chronically infected with hepatitis B virus (HBV), mostly with genotypes C and B. Level of HBV replication as measured by quantification of HBV DNA in blood is crucial for management of ...
Woottichai Khamduang, Amonrat Pota, Wanvisa Khamlasai, Sayamon Hongjaisee, Nicole Ngo-Giang-Huong, Wasna Sirirungsi   +5 more
doaj  

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

Relation of Hbv-DNA levels between serum alanin aminotransferases and serologıc markers of HBV

, 2006
Amaç: Serum HBV-DNA miktarları ile yaş, cinsiyet, serum alanin aminotransferaz (ALT) düzeyleri arasındaki ilişki varlığını incelemek. Gereç ve Yöntem: Bu çalışmada serum HBV-DNA miktarları bilinen 90 hastanın yaş, cinsiyet, serum alanin aminotransferaz ...
Zeynep Sümer, Özlem Yönem, Serpil Kaya, Levent Özdemir   +3 more
core   +1 more source