Results 111 to 120 of about 69,966 (266)

A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection

Alimentary Pharmacology &Therapeutics, EarlyView.
Cirrhosis patients with untreated HBV in Ethiopia exhibit a distinct immune profile marked by depletion of NK cells, B cells, and T cells, alongside an expanded CD38+HLA‐DR+ CD8 T‐cell population. ABSTRACT Background and Aims The immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite
Julia MacLeod, Fikadu G. Gudissa, Asiya Jeylan, Nega Berhe, Hailemichael Desalegn, Lasse Rossvoll, Asgeir Johannessen, Niklas K. Björkström, Dag Henrik Reikvam, Annika Niehrs   +9 more
wiley   +1 more source

Marked variation in eligibility criteria across registrational trials for relapsed diffuse large B‐cell lymphoma limits applicability to clinical practice

British Journal of Haematology, EarlyView.
Summary Therapeutic options for relapsed or refractory diffuse large B‐cell lymphoma (rDLBCL) have expanded following accelerated approvals based largely on surrogate end‐points, yet confirmatory studies have not consistently reproduced these benefits across all agents, and outcomes for many patients remain poor.
Elizabeth Goodall, Jodie Palmer, Arina Martynchyk, Niamh Waters, Fiona Swain, Tran Binh Giang, Tamara Marconi, Jamie Brennan, Gareth P. Gregory, Chan Cheah, Colm Keane, Eliza A. Hawkes   +11 more
wiley   +1 more source

孕妇血、脐血、乳汁的乙型肝炎病毒DNA水平及其相关性

Zhongshan Daxue xuebao. Yixue kexue ban, 2000
【目的】探讨乙型肝炎病毒(HBV)母婴垂直传播的规律, 为预防和阻断HBV 的母婴传播提供依据。【方法】对68 例HBsAg 阳性孕产妇以荧光定量PCR方法检测其静脉血、脐血、乳汁HBV DNA 含量并分析其相关性。【结果】孕妇血与脐血 HBV DNA 的含量相关系数为0.3446(P =0.008), 孕妇血与乳汁HBV DNA 的含量的相关系数为0.1449(P =0.261)。【结论】 孕妇血HBV DNA 水平与脐血HBV DNA 水平呈正相关, 降低孕妇血HBV DNA 水平 ...
李小毛, 刘穗玲, 李　霞, 黄怀筠, 卢建溪, 高志良   +5 more
doaj  

Clinical superiority of HBV RNA testing in patients with chronic hepatitis B

Frontiers in Immunology
PurposeThis study aimed to thoroughly investigate the detection levels of serum Hepatitis B Virus RNA (HBV RNA) and its clinical significance in Chronic Hepatitis B (CHB) patients before and after treatment.MethodsSerum samples were collected from 487 ...
Jing Zhou, Jing Zhou, Xiaoyan Li, Yulin Yang, Xiaomin Wang, Wenhua Xu   +5 more
doaj   +1 more source

Hepatitis B virus (HBV) DNA levels and the management of HBV-infected health care workers

, 2006
Different guidelines exist for the management of hepatitis B virus (HBV)-infected health care workers (HCWs). Various HBV DNA levels are used as a cutoff level to determine whether an HBV-infected HCW is allowed to perform exposure-prone procedures (EPPs)
de Man, R A, van der Eijk, A. A., Schalm, S. W., Zaaijer, H. L., Schalm, S W, de Man, R. A., Niesters, HGM, Schalm, Solko, van der Eijk, A A, Zaaijer, HL, Zaaijer, H L, Baltissen - van der Eijk, Annemiek, Niesters, H. G. M., Niesters, H G M, de Man, Rob, Niesters, H G M; id_orcid   +15 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

MiR‐375 in CAFs‐Derived EVs Promotes HCC Progression via Regulating RASA1 and May Potentially Serve as a Biomarker for HCC

Cancer Science, EarlyView.
CAFs could transfer EVs miR‐375 into endothelial cells with a low level of RASA1 and further promote EC angiogenesis. Plasma EVs miR‐375 have the potential values as a novel diagnostic and prognostic biomarker for HCC. ABSTRACT Cancer‐associated fibroblasts (CAFs) in the tumor microenvironment play an important role in cancer initiation and progression
Wei Qin, Li Wang, Beiyuan Hu, Cuicui Xiao, XiaoYing Wu, Huan Tian, Songlin Peng   +6 more
wiley   +1 more source

Efficacy Analysis of TACE Combined with Lenvatinib and PD-1 Inhibitors in the Treatment of Hepatitis B Virus-Related Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Jin Yu,1 Yuan Zhu,1 Shiyi Zhao,1 Xiaogang Li2 1School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, People’s Republic of China; 2Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of ...
Yu J, Zhu Y, Zhao S, Li X
doaj  

HCC-derived SNU cell lines as model systems to study HBV life cycle

Journal of Virology
Human SNU cell lines, derived from hepatocellular carcinomas associated with chronic hepatitis B virus (HBV) infection, were examined. The analysis of intracellular RNA and DNA markers of HBV replication and examination of HBV RNA readss coverage of ...
Igor Zaiets, Oleksandra Chazova, Sumedha Gunewardena, Severin O. Gudima   +3 more
doaj   +1 more source

Characterization of treatment-naive HIV/HBV co-infected patients attending ART clinic of a tertiary healthcare centre in eastern India.

PLoS ONE, 2013
ObjectiveThe study was designed to assess the hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection scenario among the human immunodeficiency virus (HIV) infected patients attending a tertiary healthcare unit in eastern India.
Debraj Saha, Ananya Pal, Avik Biswas, Rajesh Panigrahi, Neelakshi Sarkar, Jayeeta Sarkar, Manisha Pal, Subhasish Kamal Guha, Bibhuti Saha, Sekhar Chakrabarti, Runu Chakravarty   +10 more
doaj   +1 more source