Results 21 to 30 of about 2,433,705 (252)

Alinity m, a Random-Access System, for Hepatitis B Virus DNA Quantification in Plasma and Whole Blood Collected on Dried Blood Spots

mSphere, 2022
The International Liver Association recommends the use of accurate and sensitive molecular methods for determination of hepatitis B virus (HBV) DNA levels in plasma or serum of chronic HBsAg carriers. The level of HBV replication represents the strongest
Valérie Ortonne, Quentin Lucas, Olivia Garrigou, Alexandre Soulier, Dominique Challine, Jean-Michel Pawlotsky, Vincent Leroy, Stéphane Chevaliez   +7 more
doaj   +1 more source

Association Between Negative Results From Tests for HBV DNA and RNA and Durability of Response After Discontinuation of Nucles(t)ide Analogue Therapy.

Clinical Gastroenterology and Hepatology, 2020
BACKGROUND & AIMS There is no satisfactory way to identify patients who will maintain a response after discontinuation of nuleos(t)ide analogue therapy for chronic hepatitis B virus (HBV) infection.
R. Fan, Bin Zhou, Min Xu, D. Tan, J. Niu, Hao Wang, H. Ren, Xinyue Chen, Mao-rong Wang, Q. Ning, G. Shi, J. Sheng, Hong Tang, X. Bai, Shi Liu, Feng Lu, Jie Peng, Jian Sun, Q. Xie, J. Hou, M. Wan, Shijun Chen, Yanyan Yu, Hong Ma, Jun Cheng, Hongfei Zhang, Huimin Liu, Zhiliang Gao, X. Dou   +28 more
semanticscholar   +1 more source

Persistently Elevated HBV Viral-Host Junction DNA in Urine as a Biomarker for Hepatocellular Carcinoma Minimum Residual Disease and Recurrence: A Pilot Study

Diagnostics, 2023
Hepatitis B virus (HBV)-host junction sequences (HBV-JSs) has been detected in the urine of patients with HBV infection. This study evaluated HBV-JSs as a marker of minimum residual disease (MRD) and tumor recurrence after treatment in HBV-hepatocellular
Selena Y. Lin, Dina Halegoua-DeMarzio, Peter Block, Yu-Lan Kao, Jesse Civan, Fwu-Shan Shieh, Wei Song, Hie-Won Hann, Ying-Hsiu Su   +8 more
doaj   +1 more source

Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis.

Clinical Gastroenterology and Hepatology, 2020
BACKGROUND & AIMS In some individuals with undetectable serum levels of hepatitis B surface antigen (HBsAg), hepatitis B virus (HBV) DNA can still be detected in serum or hepatocytes and HBV replicates at low levels-this is called occult HBV infection ...
D. Ka-Ho Wong, Serene Ching Yan Cheng, Loey Lung-Yi Mak, Elvis Wai-Pan To, Regina Cheuk-lam Lo, T. Cheung, W. Seto, J. Fung, K. Man, Ching‐lung Lai, M. Yuen   +10 more
semanticscholar   +1 more source

Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment

Frontiers in Medicine, 2021
Background: The aim of this study was to explore the effects of endoplasmic reticulum (ER) stress on hepatitis B virus (HBV) replication and the antiviral effect of entecavir (ETV).Methods: Thapsigargin (TG) and stearic acid (SA) were used to induce ER ...
Huan Chen, Maoyuan Mu, Qichuan Liu, Han Hu, Caiyun Tian, Guoyuan Zhang, Ying Li, Fangwan Yang, Shide Lin   +8 more
doaj   +1 more source

52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic Hepatitis B [PDF]

, 2013
Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response.
Aldo Trylesinski, AS Levey, AS Lok, BJ McMahon, CJ Chen, CL Lai, DJ Tenney, DJ Tenney, DW Cockcroft, EB Keeffe, Eduardo Fassio, Fernando Bessone, H Izzedine, H Mommeja-Marin, H Yang, Henry L. Y. Chan, HL Chan, Hugo Cheinquer, Javier R. Lama, JD Jia, Jorge Daruich, KL Andersson, Liver European Association For The Study Of The, MF Yuen, MF Yuen, Mário G. Pessôa, N Leung, P Marcellin, Piyawat Komolmit, Rashidkhan Pathan, RD Cooper, RG Gish, S Mauss, S Zeuzem, Stefan Zeuzem, Suzane K. Ono, Tawesak Tanwandee, Teerha Piratvisuth, Wattana Sukeepaisarnjaroen, YF Liaw, YF Liaw, Yuhong Dong   +41 more
core   +8 more sources

3D landscape of Hepatitis B virus interactions with human chromatins

Cell Discovery, 2020
Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases.
Bo Yang, Boyuan Li, Liyang Jia, Yongpeng Jiang, Xin Wang, Shaodong Jiang, Shunda Du, Xiong Ji, Pengyuan Yang   +8 more
doaj   +1 more source

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

Highly sensitive and specific detection of HBV DNA and drug resistance mutations utilizing the PCR-based CRISPR-Cas13a system.

Clinical Microbiology and Infection, 2020
OBJECTIVES Undetectable or low-level hepatitis B virus (HBV) DNA and drug resistance mutations in patients may increase the risk of HBV transmission or cause active viral replication and other clinical problems.
Shan Wang, Hao Li, Z. Kou, F. Ren, Yi Jin, Lang Yang, Xue Dong, Mingjuan Yang, Jiangyun Zhao, Hongbo Liu, Nian Dong, L. Jia, Xinyue Chen, Yusen Zhou, S. Qiu, Rongzhang Hao, Hongbin Song   +16 more
semanticscholar   +1 more source

Persistence of extrahepatic hepatitis B virus DNA in the absence of detectable hepatic replication in patients with baboon liver transplants [PDF]

, 1995
The presence of hepatitis B virus (HBV) DNA in extrahepatic tissues has been well documented. Whether HBV DNA can persist in extrahepatic tissues for long periods of time in the absence of replication in the liver has not been determined previously ...
Davidson, Dejean, Hadchouel, Halpern, Hosoda, Jilbert, Korba, Korba, Lake, Lamelin, Lazizi, Leung, Mason, Mason, Perrillo, Pontisso, Starzl, Starzl, Todo, Yoffe   +19 more
core   +1 more source