Results 71 to 80 of about 60,065 (147)

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen   +16 more
wiley   +1 more source

Services des hbz für Alma-Bibliotheken [PDF]

open access: yes, 2016
Vortrag unter dem Titel "Services des hbz für Alma-Bibliotheken" im Rahmen des Alma-Tag für Hochschulen am 25.
Schweitzer, Roswitha
core   +3 more sources

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)

open access: yesRetrovirology, 2007
Background Activation of telomerase is a critical and late event in tumor progression. Thus, in patients with adult-T cell leukaemia (ATL), an HTLV-1 (Human T cell Leukaemia virus type 1)-associated disease, leukemic cells display a high telomerase ...
Gazzolo Louis   +5 more
doaj   +1 more source

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

open access: yesJournal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King   +4 more
doaj   +1 more source

ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

open access: yesRetrovirology, 2011
Background Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4+ T-cells caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 bZIP factor (HBZ) gene, which is encoded by the minus strand of the viral genome, is expressed as an ...
Ohshima Koichi   +4 more
doaj   +1 more source

Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis

open access: yesFrontiers in Microbiology, 2013
The production of antisense transcripts from the 3’ long terminal repeat (LTR) in human T-lymphotropic retroviruses has now been clearly demonstrated. After the identification of the antisense strand-encoded HTLV-1 bZIP (HBZ) factor, we reported that HBZ
Benoit eBarbeau   +2 more
doaj   +1 more source

Bibliotheken: Wir öffnen Daten. Zum Stand der Entwicklung einer offenen Dateninfrastruktur

open access: yeso-bib. Das offene Bibliotheksjournal, 2014
In den letzten Jahren haben sich – gerade in Deutschland – viele Bibliotheken und insbesondere Verbundzentralen entschlossen, bibliothekarische Daten unter einer offenen Lizenz zu publizieren und/oder als Linked Data aufzubereiten.
Adrian Pohl
doaj   +1 more source

hbz-Fachkonferenz zur Zukunft von Bibliotheken [PDF]

open access: yes, 2007
Im Rahmen der jährlichen Fachkonferenz des Hochschulbibliothekszentrums NRW (hbz) im Maternushaus in Köln am 30./31. Oktober 2006 diskutierten hochkarätige Bibliothekare und Wissenschaftler über die zukünftige Rolle der wissenschaftlichen und ...

core   +4 more sources

Hrvaška bratska zveza, Zajedničar in druga generacija

open access: yesDve Domovini, 1992
Prispevek osvetljuje vlogo Hrvaške bratske zveze (HBZ) in njenega tedenskega glasila Zajedničar pri krepitvi etnične identitete druge generacije hrvaških priseljencev v ZDA.
Peter J. Rachleff
doaj  

HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I.

open access: yesPLoS Pathogens, 2019
Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are no effective treatments to cure ...
Amanda W Rushing   +6 more
doaj   +1 more source

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