Results 61 to 70 of about 60,065 (147)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Making Sense out of Antisense Transcription in Human T-Cell Lymphotropic Viruses (HTLVs)

Viruses, 2011
Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' long terminal repeat (LTR), which is either unspliced or alternatively spliced.
Benoit Barbeau, Jean-Michel Mesnard
doaj   +1 more source

Microstructure and Performance Optimization of Barley Husk Ash–Blended Mortars: A Sustainable Approach to Cement Substitution

Engineering Reports, Volume 8, Issue 4, April 2026.
Barley husk ash (BHA), an agricultural byproduct rich in pozzolanic oxides, was optimized as a sustainable cement substitute. Statistical modeling and experimental validation confirmed 22.75% BHA as the optimal replacement, enhancing mechanical and durability performance while advancing eco‐efficient construction practices.
Behailu Zerihun Hailemariam, Woubishet Zewdu Taffese, Duy‐Hai Vo, Mitiku Damtie Yehualaw   +3 more
wiley   +1 more source

Metabolic Alterations in Macrophage Subtypes Propel Immune and Stromal Remodeling in Neurofibroma's Malignant Progression

MedComm, Volume 7, Issue 4, April 2026.
Illustration of the microenvironment factors driving malignant progression in MPNSTs. ABSTRACT Neurofibromatosis type 1 (NF1) is characterized by the development of benign plexiform neurofibromas (PNFs). In 10%–15% of patients, these tumors undergo malignant transformation into aggressive malignant peripheral nerve sheath tumors (MPNSTs).
Ling‐Ling Ge, Yue‐Hua Li, Xuan Yu, Ming‐Yan Xing, Yi‐Hui Gu, Wei Wang, Jing‐Xuan Huang, Jun Liu, Hai‐Bing Zhang, Cheng‐Jiang Wei, Zhi‐Chao Wang, Qing‐Feng Li   +11 more
wiley   +1 more source

hbz nimmt ASP-Betrieb für seinen zweiten LIBERO-Kunden auf [PDF]

, 2006
Das hbz (Hochschulbibliothekszentrum, Köln) hat im ASP-Betrieb (Application Service Provider) ein weiteres LIBERO Bibliotheks-Managementsystem implementiert – für die Fachhochschule Düsseldorf, eine der hbz-Verbundbibliotheken in Nordrhein-Westfalen ...

core   +3 more sources

Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1 [version 1; referees: 2 approved]

Wellcome Open Research, 2017
Background: The human leukaemia virus HTLV-1 expresses essential accessory genes that manipulate the expression, splicing and transport of viral mRNAs.  Two of these genes, tax and hbz, also promote proliferation of the infected cell, and both genes are ...
Martin R Billman, David Rueda, Charles R M Bangham   +2 more
doaj   +1 more source

Adult T‐cell leukemia/lymphoma in French Guiana (1990–2019): Epidemiology, clinical features, and HTLV‐1 genetic diversity in the two main ethnic populations

International Journal of Cancer, Volume 158, Issue 6, Page 1528-1540, 15 March 2026.
What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy, Patricia Tortevoye, Balthazar Ntab, Gabriel Carles, Jean‐Pierre Droz, Pierre Couppié, Giovanni Begliomini, Jean‐Francois Carod, N'detodji‐Bill Wankpo, Karim Abdelmoumen, Philippe V. Afonso, Olivier Cassar, Antoine Talarmin, Olivier Hermine, Loïc Epelboin, Ambroise Marçais, Antoine Gessain   +16 more
wiley   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

hbz gewinnt Bibliotheken für scantoweb-Dienstleistung [PDF]

, 2009
Das Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen (hbz) realisiert scantoweb-Lösungen für die Universitäts- und Landesbibliothek Bonn sowie die Lippische Landesbibliothek in ...

core   +3 more sources

Strategies of Human T-Cell Leukemia Virus Type 1 for Persistent Infection: Implications for Leukemogenesis of Adult T-Cell Leukemia-Lymphoma

Frontiers in Microbiology, 2020
Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection in vivo in two distinct ways: de novo infection and clonal proliferation of infected cells.
Jun-ichirou Yasunaga
doaj   +1 more source