Results 1 to 10 of about 103,474 (278)

Carbonic anhydrase inhibitors:in vitroinhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2011
A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA). The compounds were tested against four α-CA isozymes purified from human and bovine (hCA I, hCA II, bCA III, hCA IV) tissues.
D. Ekinci, L. Karagoz, D. Ekinci, M. Senturk, SUPURAN, CLAUDIU TRANDAFIR   +4 more
semanticscholar   +7 more sources

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors

Bioorganic Chemistry, 2018
In this study, new 4-[3-(aryl)-5-substitutedphenyl-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamides (19-36) were synthesized and evaluated their cytotoxic/anticancer and CA inhibitory effects. According to results obtained, the compounds 34 (4-[5-(2,3,4-trimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-yl] benzensulfonamide, Potency ...
Gul H. I., Yamali C., Sakagami H., Angeli A., Leitans J., Kazaks A., Tars K., Ozgun D. O., Supuran C. T.   +8 more
semanticscholar   +13 more sources

The synthesis of axially disubstituted silicon phthalocyanines, their quaternized derivatives and first inhibitory effect on human cytosolic carbonic anhydrase isozymes hCA I and II

RSC Advances, 2018
In this study a novel silicon(iv) phthalocyanine bearing [(2E)-3-[4-(dimethylamino)phenyl]-1-(4-phenoxy)prop-2-en-1-one] group and its quaternized derivative at their axial positions were synthesized for the first time.
Tayfun Arslan, Z. Bıyıklıoğlu, M. Şentürk   +2 more
semanticscholar   +3 more sources

The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior [PDF]

International Journal of Molecular Sciences, 2018
Although important progress has been achieved in understanding the catalytic mechanism of Carbonic Anhydrases, a detailed picture of all factors influencing the catalytic efficiency of the various human isoforms is still missing.
Martina Buonanno, A. Di Fiore, E. Langella, Katia D'Ambrosio, C. Supuran, S. Monti, G. De Simone   +6 more
semanticscholar   +2 more sources

Combined Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA): an efficient chemometric approach in aged gel inks discrimination

, 2020
The gel ink pen is the fastest growing pen class available on the modern market. Consequently, its prevalence in forensic casework is expected to increase.
Muhammad Naeim Mohamad Asri, Wan Nur Syuhaila Mat Desa, D. Ismail   +2 more
semanticscholar   +3 more sources

Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.

Bioorganic & Medicinal Chemistry, 2014
Sitaram, Gulsah Celik, Poonam Khloya, D. Vullo, C. Supuran, P. Sharma   +5 more
semanticscholar   +3 more sources

Determination of the Effect of Different Drying Methods on the Physicochemical Properties of Potato Powder Using Multivariate Analysis

Turkish Journal of Agriculture: Food Science and Technology, 2022
In this study, powder was obtained from yellow and purple-fleshed potatoes by microwave and hot air drying and the effects of drying methods on the total phenolic compounds, total monomeric anthocyanin, color, antioxidant activity, starch ratio and ...
Katibe Sinem Coruk, Hande Baltacıoğlu
doaj   +1 more source

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells

Journal of Medicinal Chemistry, 2022
In a continuing search of dual P-gp and hCA XII inhibitors, we synthesized and studied new N,N-bis(alkanol)amine aryl diester derivatives characterized by the presence of a coumarin group.
Laura Braconi, E. Teodori, C. Riganti, M. Coronnello, A. Nocentini, G. Bartolucci, M. Pallecchi, M. Contino, D. Manetti, M. Romanelli, C. Supuran, S. Dei   +11 more
semanticscholar   +1 more source

An open-label clinical trial of oral transmucosal haloperidol and oral transmucosal olanzapine in the treatment of terminal delirium at home

Trials, 2022
Background The phenomenon of restlessness, agitation, or cognitive disturbances experienced by dying patients is well-known in palliative care; more than half of these patients will experience delirium symptoms at end-of-life.
Xiao-Juan Lyu, Adrian David Kan, Poh-Heng Chong, Keegan Lin, Yung-Hua Koh, Zhi-Zheng Yeo   +5 more
doaj   +1 more source

Abiotrophia defectiva Infective Endocarditis: A Rare and Dangerous Cause of Endocarditis

Case Reports in Infectious Diseases, 2022
Infective endocarditis is an uncommon heart infection, typically involving heart valves. Abiotrophia defectiva is a rare cause of endocarditis, typically found within the GI tract, and is usually difficult to isolate and requires specialized media.
Ian Lancaster, Deep Patel, Cyrus Tamboli, Patricia Chun, Vikas Sethi, Joseph Namey   +5 more
doaj   +1 more source