Results 201 to 210 of about 305,562 (334)

Comprehensive analysis of prognostic immune-related genes in the tumor microenvironment of hepatocellular carcinoma (HCC)

, 2021
Mengting Li, Hong-Liang Li, Canxin Zhou, Xianpeng Li, Jiande Gong, Changxi Chen, Yi Zhang   +6 more
openalex   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

The alternative splicing landscape of hepatocellular carcinoma and its potential for HCC detection. [PDF]

Hepatol Commun
Hershberger CE, Daniels NJ, Patterson WM, Rotroff DM.   +3 more
europepmc   +1 more source

T-11 5-year entecavir in NUC-naïve, field-practice patients with CHB showed excellent viral suppression and safety but no prevention of HCC

, 2013
Pietro Lampertico, R. Soffredini, Mauro Viganò, E. Minola, Giuliana Cologni, María Rízzí, S. Zaltron, Andrea Vavassori, Francesco Castelli, Elena Angeli, G. Gubertini, C. Magni, Giuliano Rizzardini, Anna Testa, Giampiero D’Offizi, M. Vinci, G. Pinzello, E. Fatta, Silvia Fargion, Sílvia Colombo, O. Fracassetti, P. Del Poggio, B. Coco, Maurizia Rossana Brunetto, M. Andreoletti, Agostino Colli, M. Fasano, Teresa Santantonio, Guido Colloredo, L. Pasulo, S. Fagiuoli, Alberto Colombo, G. Bellati, M. Milanese, Mario Strazzabosco, Massimo Pozzi, N. Terreni, Giancarlo Spinzi, M. Quagliuolo, Mauro Borzio, G. Lunghi, F. Facchetti, Federica Invernizzi, M. Colombo   +43 more
openalex   +1 more source

A Dual‐Locking G‐Quadruplex DNA Targeting Strategy Based on a Tumor‐Accumulating Porphyrin‐Ruthenium(II) Conjugate for Type I Photodynamic Therapy

Aggregate, EarlyView.
This study identifies PorRu as a “dual‐lock” G‐quadruplex binder, which also serves as a tumor‐targeting Type I photosensitizer. This agent overcomes the limitations of oxygen‐dependent PDT, providing a novel strategy for precise HCC therapy. ABSTRACT The hypoxic tumor microenvironment severely limits the effectiveness of photodynamic therapy (PDT) in ...
Qiong Wu, Wan‐Wan Hong, Jia‐Hui Shi, Ren‐Shan Deng, Wan‐Qi Chen, Chan‐Ling Yuan, Wen‐Jie Mei   +6 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Complete Remission of Hepatocellular Carcinoma With Atezolizumab and Bevacizumab Following Prior B-cell Depletion. [PDF]

J Immunother
Huang JP, Tsai CK, Hsieh PY, Chen SC.
europepmc   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source