Results 11 to 20 of about 28,017 (205)
Human Cytomegalovirus (HCMV) – Revised [PDF]
Transfusion Medicine and Hemotherapy, 2010 Schottstedt, Volkmar +16 more
openaire +5 more sources
CARs—A New Perspective to HCMV Treatment [PDF]
Viruses, 2021 Human cytomegalovirus (HCMV), by primary infection or reactivation, represents a great risk for immune-suppressed or compromised patients. In immunocompetent humans, the immune system suppresses the spread of HCMV during an infection, resulting in a mostly asymptomatic or mild course of the disease, whereas in immune suppressed patients, the ...
Christopher Bednar, Armin Ensser
openaire +5 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a well-studied herpesvirus, has been implicated in malignancies derived from breast, colorectal muscle, brain, and other cancers.
Chuan Yu +5 more
semanticscholar +1 more source
Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation [PDF]
, 2014 NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A ...
A Dolan +98 more
core +14 more sources
Is HCMV a tumor promoter? [PDF]
Virus Research, 2011 Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals. Although HCMV is not currently causally implicated in human cancer, emerging evidence suggests that HCMV infection and expression may be specifically associated with human malignancies ...
Liliana Soroceanu +2 more
openaire +3 more sources
Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes [PDF]
Virology Journal, 2020 Abstract Background Human cytomegalovirus (HCMV) causes asymptomatic infections, but also causes congenital infections when women were infected with HCMV during pregnancy, and life-threatening diseases in immunocompromised patients. To better understand the mechanism of the neutralization activity against HCMV, the association of HCMV NT antibody ...
Souichi Yamada +15 more
openaire +4 more sources
American Journal of Transplantation, 2020 Letermovir (LMV) inhibits HCMV replication by binding to components of the HCMV‐terminase complex showing a potential role in prevention of HCMV‐related complications in allogenic hematopoietic stem cell transplant recipients (allo‐HSCTRs).
I. Cassaniti +15 more
semanticscholar +1 more source
Regulation of the MIE Locus During HCMV Latency and Reactivation
Pathogens, 2020 Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which is broadly defined by transcriptional silencing and the absence of de novo
Abigail L Dooley, C. O’Connor
semanticscholar +1 more source
Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome [PDF]
Journal of Virology, 2004 ABSTRACT Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been known for over a decade, the full set of viral and cellular proteins that compose the HCMV virion are unknown.
Thomas Shenk +13 more
openaire +5 more sources
Tuning the Orchestra: HCMV vs. Innate Immunity
Frontiers in Microbiology, 2020 Understanding how the innate immune system keeps human cytomegalovirus (HCMV) in check has recently become a critical issue in light of the global clinical burden of HCMV infection in newborns and immunodeficient patients. Innate immunity constitutes the
Valentina Dell’Oste +8 more
semanticscholar +1 more source