Results 11 to 20 of about 33,214 (206)

Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts [PDF]

The Journal of Infectious Diseases, 2002
Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly ...
Burroughs, AK, Emery, VC, Griffiths, PD, Hassan-Walker, AF   +3 more
core   +6 more sources

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR-T Cell Recipients-PART 2: Antiviral Therapy and Virus-Specific T Cell Therapy for HCMV in Allo-HSCT. [PDF]

Rev Med Virol
ABSTRACT Human cytomegalovirus (HCMV) reactivation is a common and significant complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), causing potentially life‐threatening disease. Antiviral therapy approaches for HCMV are often limited by toxicities and the risk of developing antiviral drug resistance.
Sutrave G, Yong MK, Kaplan D, Gottlieb DJ, Abendroth A, Slobedman B, Blyth E, Stern L.   +7 more
europepmc   +2 more sources

Development of CpG-Depleted CFTR Plasmid-Based Nanoparticles for Nonviral Gene Therapy in Lung Cystic Fibrosis Disease. [PDF]

J Gene Med
Well designed CpG‐depleted CFTR nanoparticles for cystic fibrosis. ABSTRACT Nonviral gene therapy holds promise as a potential treatment for lung cystic fibrosis (CF). However, the transient expression of the CF transmembrane conductance regulator (CFTR) protein has limited its clinical application.
Qiu B, Lorino M, Li Y, He Z, Wang X, Wang W, Lara-Sáez I.   +6 more
europepmc   +2 more sources

HCMV Envelope Glycoprotein Diversity Demystified [PDF]

Frontiers in Microbiology, 2019
Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals. Considerable efforts have been deployed over the last decade to develop a vaccine capable of preventing HCMV infection.
Mathilde Foglierini, Mathilde Foglierini, Jessica Marcandalli, Laurent Perez   +3 more
openaire   +4 more sources

Functionalized Cyclic Beta-Amino Acid Derivatives With Antiviral Potential. [PDF]

ChemMedChem
Selected highly functionalized cyclic beta (β)‐amino acid derivatives have been synthesized according to modified and improved literature synthetic protocols and subjected to various antiviral studies. The model compounds were regio‐ and stereoisomers of azido‐functionalized β‐amino esters, orthogonally protected diamino esters, an oxirane‐fused cyclic
Nonn M, Denel-Bobrowska M, Volk B, Olejniczak AB, Kiss L.   +4 more
europepmc   +2 more sources

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome [PDF]

Journal of Virology, 2004
ABSTRACT Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been known for over a decade, the full set of viral and cellular proteins that compose the HCMV virion are unknown.
Susan M, Varnum, Daniel N, Streblow, Matthew E, Monroe, Patricia, Smith, Kenneth J, Auberry, Ljiljana, Pasa-Tolic, Dai, Wang, David G, Camp, Karin, Rodland, Steven, Wiley, William, Britt, Thomas, Shenk, Richard D, Smith, Jay A, Nelson   +13 more
openaire   +3 more sources

Small Molecules—Prospective Novel HCMV Inhibitors [PDF]

Viruses, 2021
Human cytomegalovirus (HCMV), a member of the betaherpesvirinae, can cause life-threatening diseases. HCMV is globally widespread, with a seroprevalence in adults varying from 50 to 100%. HCMV infection is rarely of significant consequence in immunocompetent individuals.
Elke Bogner, Anna Egorova, Vadim Makarov
openaire   +3 more sources

US28: HCMV’s Swiss Army Knife [PDF]

Viruses, 2018
US28 is one of four G protein coupled receptors (GPCRs) encoded by human cytomegalovirus (HCMV). The US28 protein (pUS28) is a potent signaling molecule that alters a variety of cellular pathways that ultimately alter the host cell environment. This viral GPCR is expressed not only in the context of lytic replication but also during viral latency ...
Krishna, Benjamin A, Miller, William E, O'Connor, Christine M   +2 more
openaire   +3 more sources

Insight for Immunotherapy of HCMV Infection [PDF]

International Journal of Biological Sciences, 2021
Human cytomegalovirus (HCMV), a ubiquitous in humans, has a high prevalence rate. Young people are susceptible to HCMV infection in developing countries, while older individuals are more susceptible in developed countries. Most patients have no obvious symptoms from the primary infection.
Long, Xinmiao, Qiu, Yi, Zhang, Zuping, Wu, Minghua   +3 more
openaire   +2 more sources

HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection? [PDF]

Viruses, 2018
Human cytomegalovirus (HCMV) infection of peripheral blood monocytes plays a key role in the hematogenous dissemination of the virus to multiple organ systems following primary infection or reactivation of latent virus in the bone marrow. Monocytes have a short life span of 1–3 days in circulation; thus, HCMV must alter their survival and ...
Donna Collins-McMillen, Liudmila Chesnokova, Byeong-Jae Lee, Heather L. Fulkerson, Reynell Brooks, Bailey S. Mosher, Andrew D. Yurochko   +6 more
openaire   +3 more sources