Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV
Viruses, 2019 Human cytomegalovirus (HCMV) infects more than 70% of the human population worldwide. HCMV is responsible for high morbidity and mortality in immunocompromised patients and remains the leading viral cause of congenital birth defects. Despite considerable
Michela Perotti, Laurent Perez
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Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]
, 2019 Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang +8 more
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Priming of NK cell anti-viral effector mechanisms by direct recognition of Human Cytomegalovirus
Frontiers in Immunology, 2013 NK cells play an important role in the defense against viral infections. Activation of resting NK cells is tightly controlled by the balance of surface inhibitory and activating receptors and aided by cytokines released by accessory cells along the anti ...
Aura eMuntasell +6 more
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Clinical & Translational Immunology, 2023 Objectives Human cytomegalovirus (HCMV) reactivation is the leading viral complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT).
Lauren Stern +7 more
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Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
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Functionalized Cyclic Beta-Amino Acid Derivatives With Antiviral Potential. [PDF]
ChemMedChemSelected highly functionalized cyclic beta (β)‐amino acid derivatives have been synthesized according to modified and improved literature synthetic protocols and subjected to various antiviral studies. The model compounds were regio‐ and stereoisomers of azido‐functionalized β‐amino esters, orthogonally protected diamino esters, an oxirane‐fused cyclic
Nonn M +4 more
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Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]
, 1994 The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H. +4 more
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Journal of Pure and Applied Microbiology, 2019 Oral carcinogenesis is a multi-step process, affecting predominantly elderly males with a long history of smoking and alcohol drinking while the role of infectious agents in its progression has not been fully identified.
Hayat Ghaith Sachit +4 more
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Spanish HCMV Seroprevalence in the 21st Century
Viruses, 2023 Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals.
Pablo Álvarez-Heredia +13 more
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Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]
, 2017 Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P. +19 more
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