Results 11 to 20 of about 17,820 (185)

Insight for Immunotherapy of HCMV Infection [PDF]

International Journal of Biological Sciences, 2021
Human cytomegalovirus (HCMV), a ubiquitous in humans, has a high prevalence rate. Young people are susceptible to HCMV infection in developing countries, while older individuals are more susceptible in developed countries. Most patients have no obvious symptoms from the primary infection.
Long, Xinmiao, Qiu, Yi, Zhang, Zuping, Wu, Minghua   +3 more
openaire   +2 more sources

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights. [PDF]

Rev Med Virol
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
AlQahtani HY, Aleanizy FS, Alqahtani FY.
europepmc   +2 more sources

The C-Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus. [PDF]

Eur J Immunol
Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle‐dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages.
Bokun V, Chai W, Buchanan R, Murphy E, Liu Y, Holder B, Decout A.   +6 more
europepmc   +2 more sources

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome [PDF]

Journal of Virology, 2004
ABSTRACT Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been known for over a decade, the full set of viral and cellular proteins that compose the HCMV virion are unknown.
Susan M, Varnum, Daniel N, Streblow, Matthew E, Monroe, Patricia, Smith, Kenneth J, Auberry, Ljiljana, Pasa-Tolic, Dai, Wang, David G, Camp, Karin, Rodland, Steven, Wiley, William, Britt, Thomas, Shenk, Richard D, Smith, Jay A, Nelson   +13 more
openaire   +3 more sources

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes [PDF]

Virology Journal, 2020
Abstract Background Human cytomegalovirus (HCMV) causes asymptomatic infections, but also causes congenital infections when women were infected with HCMV during pregnancy, and life-threatening diseases in immunocompromised patients.
Miho Shibamura, Tomoki Yoshikawa, Souichi Yamada, Takuya Inagaki, Phu Hoang Anh Nguyen, Hikaru Fujii, Shizuko Harada, Shuetsu Fukushi, Akira Oka, Masashi Mizuguchi, Masayuki Saijo   +10 more
openaire   +3 more sources

Human Cytomegalovirus (HCMV) Replication Dynamics in HCMV‐Naive and ‐Experienced Immunocompromised Hosts [PDF]

The Journal of Infectious Diseases, 2002
Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly faster than the growth rate of virus in HCMV-experienced hosts undergoing recurrent infection (0.61 ...
Vincent C, Emery, Aycan F, Hassan-Walker, Andrew K, Burroughs, Paul D, Griffiths   +3 more
openaire   +2 more sources

HCMV Assembly Is Totally Tubular [PDF]

Developmental Cell, 2018
Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules and regulates infectious virion ...
Shelby M, Lyon, Robert F, Kalejta
openaire   +2 more sources

Is HCMV a tumor promoter? [PDF]

Virus Research, 2011
Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals. Although HCMV is not currently causally implicated in human cancer, emerging evidence suggests that HCMV infection and expression may be specifically associated with human malignancies ...
Liliana, Soroceanu, Charles S, Cobbs
openaire   +2 more sources

Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Polish Journal of Microbiology, 2023
Human Cytomegalovirus (HCMV) is a leading healthcare problem associated with stillbirth and congenital abnormalities. Determining the seroprevalence and the possible risk factors related to HCMV infections may be a cornerstone in preventing its ...
Moglad Ehssan H., Hassan Ahmed O., Atta Elmanan Mawada S., Saeed Samar M., Abdalla Wafaa Mohammed, Mohammedsalih Kawthar Abdelgaleil, Ali Hatim T., Abd Elaziz Mohammed Siddig, Ahmed Hind Haidar   +8 more
doaj   +1 more source

Challenging the Conventional Interpretation of HCMV Seronegativity [PDF]

Microorganisms, 2021
The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva so infection events are likely to be common. Indeed it is hard to imagine a life without exposure to HCMV.
Shelley Waters, Silvia Lee, Ashley Irish, Patricia Price   +3 more
openaire   +5 more sources