Results 41 to 50 of about 28,017 (205)

Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog [PDF]

, 1992
In several herpesviruses the genes for the major DNA binding protein (MDBP), a putative assembly protein, the glycoprotein B (gB), and the viral DNA polymerase (pol) coliocate.
Keil, Günther M., Koszinowski, Ulrich H., Messerle, Martin, Schneider, Karin   +3 more
core   +1 more source

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. [PDF]

, 2020
Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit ...
Akard, Luke, Chemaly, Roy, Christoph, Sandra, Gerbitz, Armin, Hiemenz, John, Holler, Ernst, Hwang, William YK, Jang, Junho, Koh, Liang Piu, Lee, Dong-Gun, Logan, Aaron C, Long, Gwynn, Maertens, Johan, Mielke, Stephan, Pertel, Peter, Ramachandra, Sangana, Segal, Florencia, Smith, Kristin, Tang, Jih-Luh, Wang, Po-Nan, Winkler, Julia, Yeh, Su-Peng, Yeo, Adeline   +22 more
core   +3 more sources

The microRNA Transcriptome of Human Cytomegalovirus (HCMV) [PDF]

The Open Virology Journal, 2012
The purpose of the present study was to characterize the microRNA transcriptome (miRNAome) of the human cytomegalovirus (HCMV or HHV5). We used deep sequencing and real time PCR (qPCR) together with bioinformatics to analyze the pattern of small RNA expression in cells infected with low-passage isolates of HCMV as well as in plasma and amniotic fluid ...
Zvi Bentwich, Klara Kedem, Irit Reichenstein, Yonat Shemer Avni, Noam Shomron, Michal Ziv-Ukelson, Mesfin K. Meshesha, Isana Veksler-Lublinsky, Ofer Isakov   +8 more
openaire   +3 more sources

Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV

Viruses, 2019
Human cytomegalovirus (HCMV) infects more than 70% of the human population worldwide. HCMV is responsible for high morbidity and mortality in immunocompromised patients and remains the leading viral cause of congenital birth defects. Despite considerable
Michela Perotti, L. Perez
semanticscholar   +1 more source

A model for HCMV infection in immunosuppressed patients

Mathematical and Computer Modelling, 2009
We propose a model for HCMV infection in healthy and immunosuppressed patients. First, we present the biological model and formulate a system of ordinary differential equations to describe the pathogenesis of primary HCMV infection in immunocompetent and immunosuppressed individuals.
Marie Davidian, Grace M. Kepler, Harvey Thomas Banks, Eric S. Rosenberg   +3 more
openaire   +3 more sources

Human cytomegalovirus: taking the strain [PDF]

, 2015
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments.
Aicheler, Rebecca, Davison, Andrew J., Fielding, Ceri A., Lehner, Paul J., Murrell, Isa, Seirafian, Sepher, Stanton, Richard J., Tomasec, Peter, Wang, Edward C. Y., Weekes, Michael, Wilkie, Gavin, Wilkinson, Gavin W. G.   +11 more
core   +3 more sources

Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

International Journal of Molecular Sciences, 2019
The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors.
A. Aiello, G. Accardi, G. Candore, C. Caruso, C. Colomba, D. Di Bona, G. Duro, C. Gambino, M. E. Ligotti, J. Pandey   +9 more
semanticscholar   +1 more source

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes [PDF]

, 2016
Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation.
Atkinson, Claire, Balloux, Francois, Breuer, Judith, Brown, Amanda C., Brown, Julianne R., Christiansen, Mette T., Clark, Duncan A., Depledge, Daniel P., Einer-Jensen, Katja, Griffiths, Paul D., Holdstock, Jolyon, Lassalle, Florent, Milne, Richard S.B., Reeves, Matthew B., Schutten, Martin, Tutill, Helena J., van Loenen, Freek B., Verjans, Georges M.G.M., Williams, Rachel J.   +18 more
core   +1 more source

The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells

Molecules, 2018
Glioblastoma (GBM), the most common type of primary tumor in the central nervous system, is a very aggressive brain tumor with poor prognosis and a high recurrence rate.
Jing-yi Song, Q. Ma, Ming Hu, D. Qian, Bin Wang, Ningning He   +5 more
semanticscholar   +1 more source

Suppressive effects of pterostilbene on human cytomegalovirus (HCMV) infection and HCMV-induced cellular senescence

Virology Journal, 2022
Abstract Background Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, causes the establishment of a latent infection that persists throughout the life of the host and can be reactivated when immunity is weakened.
Sanying Wang, Xuqiang Zhou, Xinyue He, Shushu Ma, Chuan Sun, Jing Zhang, Xiaogang Xu, Weihua Jin, Jin Yan, Ping Lin, Genxiang Mao   +10 more
openaire   +3 more sources