Results 41 to 50 of about 33,214 (206)

Challenging the Conventional Interpretation of HCMV Seronegativity [PDF]

Microorganisms, 2021
The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva so infection events are likely to be common. Indeed it is hard to imagine a life without exposure to HCMV.
Shelley Waters, Silvia Lee, Ashley Irish, Patricia Price   +3 more
openaire   +5 more sources

Features of memory-like and PD-1+ human NK cell subsets

Frontiers in Immunology, 2016
Human NK cells are distinguished into CD56brightCD16- cells and CD56dimCD16+ cells. These two subsets are conventionally associated with differential functional outcomes and are heterogeneous with respect to the expression of KIR and CD94/NKG2 ...
Mariella Della Chiesa, Silvia Pesce, Letizia Muccio, Simona Carlomagno, Simona Sivori, Simona Sivori, Alessandro Moretta, Alessandro Moretta, Emanuela Marcenaro, Emanuela Marcenaro   +9 more
doaj   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Identification and characterization of human cytomegalovirus-encoded circular RNAs

Frontiers in Cellular and Infection Microbiology, 2022
Circular RNA (circRNA) exists extensively and plays essential roles in serving as microRNA (miRNA) or protein sponges and protein scaffolding in many organisms.
Jingui Deng, Jingui Deng, Qing Wang, Jing Zhang, Jing Zhang, Jing Zhang, Yanping Ma, Yanping Ma, Ying Qi, Ying Qi, Ying Qi, Zhongyang Liu, Zhongyang Liu, Zhongyang Liu, Yibo Li, Yibo Li, Qiang Ruan, Qiang Ruan, Qiang Ruan, Yujing Huang, Yujing Huang, Yujing Huang   +21 more
doaj   +1 more source

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]

, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan, Chan, Karen, Dai, Xinghong, Jih, Jonathan, Liu, Fenyong, Liu, Wei, Mei, Ye, Trang, Phong, Yu, Xuekui, Zhou, Z Hong   +9 more
core   +2 more sources

CD1d expression and invariant NKT cell responses in herpesvirus infections

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor (TCR) and surface markers shared with the natural killer cell lineage.
Rusung eTan
doaj   +1 more source

MECHANISMS OF IMMUNOLOGICAL TOLERANCE DISRUPTION

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016
Autoimmune diseases belong to disorders with an unclear etiology. The spectrum of autoimmune diseases is wide, the most well known of them are type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn’s disease ...
Polina Kravchenko, Evgenia Oleinik
doaj   +1 more source

Different expression pattern of human cytomegalovirus-encoded microRNAs in circulation from virus latency to reactivation

Journal of Translational Medicine, 2020
Background Human cytomegalovirus (HCMV) is a beta-hersvirinae that has a high latent infection rate worldwide and can cause serious consequences in immunocompromised patients when reactivation; however, the mechanism of how HCMV convert from latent to ...
Wanqing Zhou, Cheng Wang, Meng Ding, Yuying Bian, Yujie Zhong, Han Shen, Junjun Wang, Chen-Yu Zhang, Chunni Zhang   +8 more
doaj   +1 more source

The Viral Load of Human Cytomegalovirus Infection in Children following Hematopoietic Stem Cell Transplant by Chip Digital PCR

Canadian Journal of Infectious Diseases and Medical Microbiology, 2022
Objective. To detect viral load in human cytomegalovirus (HCMV) infection children after hematopoietic stem cell transplant (HSCT) by chip digital PCR (cdPCR). Methods.
Wen-Jun Wang, Miao Feng, Feng He, Juan Song, Qin-Qin Song, Dong Xia, Rong Liu, Hai-Lan Yao, Jun Han   +8 more
doaj   +1 more source