Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]
, 2014 The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core +3 more sources
Sustained gene expression in the retina by improved episomal vectors [PDF]
, 2014 Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira +7 more
core +1 more source
HCMV latency: what regulates the regulators?
Medical Microbiology and Immmunology, 2019 Human cytomegalovirus (HCMV) latency and reactivation is regulated by the chromatin structure at the major immediate early promoter (MIEP) within myeloid cells.
Elizabeth G. Elder, J. Sinclair
semanticscholar +1 more source
Deciphering novel host-herpesvirus interactions by proteomics
Frontiers in Microbiology, 2012 Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than ...
Roger eLippé
doaj +1 more source
Spanish HCMV Seroprevalence in the 21st Century
Viruses, 2023 Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals.
Pablo Álvarez-Heredia +13 more
doaj +1 more source
Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]
, 1994 The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H. +4 more
core +1 more source
The oncogenic potential of human cytomegalovirus and breast cancer.
Frontiers in Oncology, 2014 Breast cancer is among the leading causes of cancer-related death among women. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland.
Georges eHerbein, Amit eKumar
doaj +1 more source
The Reactivity of Anti-HCMV IgM to Various Specific HCMV Antigens Among Pregnant Women in Kirkuk. [PDF]
Kirkuk Journal of Science, 2018 Human Cytomegalovirus (HCMV) is a DNA virus of the Betaherpesvirinae subfamily and Herpesviridae family. HCMV is a leading cause of congenital infections throughout the world.
Staar Qader +2 more
doaj +1 more source
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
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Challenging the Conventional Interpretation of HCMV Seronegativity [PDF]
Microorganisms, 2021 The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva so infection events are likely to be common. Indeed it is hard to imagine a life without exposure to HCMV.
Shelley Waters +3 more
openaire +5 more sources