Results 61 to 70 of about 46,134 (291)

Features of memory-like and PD-1+ human NK cell subsets

Frontiers in Immunology, 2016
Human NK cells are distinguished into CD56brightCD16- cells and CD56dimCD16+ cells. These two subsets are conventionally associated with differential functional outcomes and are heterogeneous with respect to the expression of KIR and CD94/NKG2 ...
Mariella Della Chiesa, Silvia Pesce, Letizia Muccio, Simona Carlomagno, Simona Sivori, Simona Sivori, Alessandro Moretta, Alessandro Moretta, Emanuela Marcenaro, Emanuela Marcenaro   +9 more
doaj   +1 more source

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Human cytomegalovirus (HCMV) causes severe morbidity and mortality in immunocompromised patients and is the most commonly transmitted virus that causes developmental defects in the fetus.
Adam Vanarsdall, Andrea Chin, Jing Liu, T. Jardetzky, James O. Mudd, S. Orloff, D. Streblow, M. Mussi-Pinhata, A. Yamamoto, G. Duarte, W. Britt, David C. Johnson   +11 more
semanticscholar   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source

A Review of the Potential Role of Human Cytomegalovirus (HCMV) Infections in Breast Cancer Carcinogenesis and Abnormal Immunity

Cancers, 2019
Previously recognized classical human onco-viruses can regulate complex neoplastic events, and are estimated to play a role during carcinogenesis in 15–20% of cancer cases.
J. Geisler, J. Touma, A. Rahbar, C. Söderberg-Nauclér, K. Vetvik   +4 more
semanticscholar   +1 more source

A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]

, 2010
Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved.
Li, Hong, Ren, Li, Wang, Anyou
core   +4 more sources

Battle between Host Immune Cellular Responses and HCMV Immune Evasion

International Journal of Molecular Sciences, 2019
Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be severely pathogenic for the fetus during pregnancy and in immunocompromised ...
T. Manandhar, Gia-Gia T. Hò, Wiebke C Pump, R. Blasczyk, C. Bade-Doeding   +4 more
semanticscholar   +1 more source

MECHANISMS OF IMMUNOLOGICAL TOLERANCE DISRUPTION

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016
Autoimmune diseases belong to disorders with an unclear etiology. The spectrum of autoimmune diseases is wide, the most well known of them are type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn’s disease ...
Polina Kravchenko, Evgenia Oleinik
doaj   +1 more source

Identification and characterization of human cytomegalovirus-encoded circular RNAs

Frontiers in Cellular and Infection Microbiology, 2022
Circular RNA (circRNA) exists extensively and plays essential roles in serving as microRNA (miRNA) or protein sponges and protein scaffolding in many organisms.
Jingui Deng, Jingui Deng, Qing Wang, Jing Zhang, Jing Zhang, Jing Zhang, Yanping Ma, Yanping Ma, Ying Qi, Ying Qi, Ying Qi, Zhongyang Liu, Zhongyang Liu, Zhongyang Liu, Yibo Li, Yibo Li, Qiang Ruan, Qiang Ruan, Qiang Ruan, Yujing Huang, Yujing Huang, Yujing Huang   +21 more
doaj   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways

Nature Communications, 2019
The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways ...
Areum Park, E. Ra, Taeyun A. Lee, H. Choi, Eunhye Lee, Sujin Kang, J. Seo, Sungwook Lee, Boyoun Park   +8 more
semanticscholar   +1 more source