Results 61 to 70 of about 44,631 (298)
Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]
, 2014 The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core +3 more sources
bioRxiv, 2019 Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following ...
I. Mikell +6 more
semanticscholar +1 more source
Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]
, 2018 Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni +10 more
core +2 more sources
Nature Communications, 2019 The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways ...
Areum Park +8 more
semanticscholar +1 more source
HCMV Assembly Is Totally Tubular [PDF]
Developmental Cell, 2018 Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules and regulates infectious virion ...
Robert F. Kalejta, Shelby M. Lyon
openaire +3 more sources
An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]
, 1992 The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Koszinowski, Ulrich H. +3 more
core +1 more source
Medicine, 2019 The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development.
Oscar del Moral-Hernández +9 more
semanticscholar +1 more source
HCMV GrAbs a Mechanism to Escape Neutralization [PDF]
Cell Host & Microbe, 2011 The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of Cell Host & Microbe, Manley et al. (2011) found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected ...
Tina M. Cairns +2 more
openaire +3 more sources
The role of IFN-gamma in Humoral immune response for HCMV antigens among pregnant women
Al-Kitab Journal for Pure Sciences, 2023 Background: Human cytomegalovirus (HCMV) is a highly host-specific virus belongs to the β-herpesvirus subfamily, which is a leading cause of congenital infections.
Staar Mohammed Qader +1 more
doaj +1 more source
Impact of sequence variation in the ul128 locus on production of human cytomegalovirus in fibroblast and epithelial cells [PDF]
, 2013 The human cytomegalovirus (HCMV) virion envelope contains a complex consisting of glycoproteins gH and gL plus proteins encoded by the UL128 locus (UL128L): pUL128, pUL130, and pUL131A.
A. J. Davison +87 more
core +2 more sources