Results 61 to 70 of about 28,017 (205)

The S‐Phase Arrest of Host Cells Caused by an Alpha‐Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes

Cell Proliferation, EarlyView.
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang, Ying Wu, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng   +16 more
wiley   +1 more source

Primary Human Cytomegalovirus (HCMV) Infection in Pregnancy.

Deutsches Ärzteblatt International, 2017
BACKGROUND In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain,
H. Buxmann, K. Hamprecht, M. Meyer-Wittkopf, K. Friese   +3 more
semanticscholar   +1 more source

Gene cloning of the human cytomegalovirus (HCMV) antigen reactive with the serum from a HCMV-infected patient [PDF]

Journal of Korean Medical Science, 1994
The human cytomegalovirus(HCMV) gene encoding the protein reactive with the sera of HCMV-infected patient was cloned and characterized. A reactive phage clone was screened from a lambda gt11 expression library of cDNA of HCMV AD169 strain using HCMV-infected patient sera.
Ju Young Seoh, Mee Na Kim, Yoon Hoh Kook, Hoan Jong Lee, Dong Gyun Lim, Chang Yong Cha, Sung Bae Choi, Eung Soo Hwang, Chung Gyu Park, Jae-Won Park   +9 more
openaire   +3 more sources

An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]

, 1992
The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Koszinowski, Ulrich H., Messerle, Martin, Münch, Konrad, Plachter, Bodo   +3 more
core   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Single Chain Antibodies Against gp55 of Human Cytomegalovirus (HCMV) for Prophylaxis and Treatment of HCMV Infections [PDF]

Jundishapur Journal of Microbiology, 2016
Immunotherapy is a promising prospective new treatment for cytomegalovirus (CMV) infections. Neutralizing effects have been reported using monoclonal antibodies. Recombinant single chain antibodies (scFvs) due to their advantages over monoclonal antibodies are potential alternatives and provide valuable clinical agents.The aim of this study was to ...
Foroogh Nejatollahi, Bahareh Moazen, Elahe Ebrahimi   +2 more
openaire   +3 more sources

Impact of sequence variation in the ul128 locus on production of human cytomegalovirus in fibroblast and epithelial cells [PDF]

, 2013
The human cytomegalovirus (HCMV) virion envelope contains a complex consisting of glycoproteins gH and gL plus proteins encoded by the UL128 locus (UL128L): pUL128, pUL130, and pUL131A.
A. J. Davison, Adler, Adler, Akter, Baldanti, Borst, Boyle, Britt, Bronzini, Brunak, Cha, Chan, Chowdary, Compton, Compton, Cunningham, D. J. Dargan, Dargan, Davison, Desmet, Dogan, Dolan, Erice, Feire, Fouts, G. S. Wilkie, Genini, Gerna, Gerna, Grazia Revello, Hahn, Hahn, Haspot, I. Murrell, Irmiere, Isaacson, Isaacson, Jiang, Kari, Kelley, Kinzler, Lilleri, Lopper, Macagno, Magri, Matrosovich, Mocarski, Murphy, O'Connor, P. Tomasec, Paredes, Paterson, Prichard, R. J. Stanton, Rasmussen, Reese, Revello, Ryckman, Ryckman, Ryckman, Saccoccio, Schleiss, Schuessler, Schuessler, Schuessler, Scrivano, Sinclair, Sinzger, Sinzger, Sinzger, Sinzger, Smith, Soroceanu, Stanton, Stanton, Stanton, Stanton, Straschewski, Sun, Talbot, Vanarsdall, Vanarsdall, Wang, Wang, Wang, Warming, Wille, Yu   +87 more
core   +2 more sources

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal, EarlyView.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio, Luis A. Baeza, Haiqing Bai, Tommaso Colangelo, Simone Castagnozzi, Marta Marzotto, Maria Concetta Cufaro, Virginia Lotti, Yu‐Chieh Yuan, Matteo Mucci, Longlong Si, Mariachiara Zuccarini, Maria Tredicine, Simona D'Orazio, Damiana Pieragostino, Piero Del Boccio, Claudio Sorio, Marco Trerotola, Mario Romano, Roberto Plebani   +19 more
wiley   +1 more source

The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts

Viruses, 2018
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
M. Nukui, C. O’Connor, Eain A. Murphy
semanticscholar   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source