Results 91 to 100 of about 4,460,555 (293)
Knockdown of Akt induces HCT116 cells a phenotype change.
, 2014 (A) HTC116 cells transfected with negative control siRNA (Original amplification of 100×). (B) HTC116 cells transfected with siRNA of Akt1/2. (Original amplification of 200×).
Chang Gong Lee (509341) +4 more
core +1 more source
SURF6 knockdown affects cell cycle distribution of HCT116 human intestinal carcinoma cells.
, 2023 (A) Western blot analysis of SURF6 and p53 levels in HCT116 p53+ and HCT116 p53- cell lines treated with anti-SURF6 siRNA or non-targeting siRNA as a control. Anti-actin staining was used for normalization.
Kira Dobrochaeva (16548428) +9 more
core +1 more source
Advanced Science, EarlyView.This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang +8 more
wiley +1 more source
MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Oxaliplatin resistance limits the efficiency of treatment for colorectal cancer (CRC). Studies have shown that abnormal expression of microRNAs (miRNAs) were associated with tumorigenesis, cancer development and chemoresistance. The purpose of this study
Hui Liang +8 more
doaj +1 more source
Genome-wide transcriptome analysis of miR-34 OE HCT116 cells.
, 2015 (A) Overlap of genes down-regulated ≥ 1.5 fold in miR-34 OE HCT116 cells compared to control-transfected cells.
Judy Lieberman (19826) +1 more
core +1 more source
Advanced Science, EarlyView.An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang +5 more
wiley +2 more sources
Gfi-1 modulates HMGB1-Mediated autophagy to overcome oxaliplatin resistance in colorectal cancer
HeliyonBackground: Resistance to oxaliplatin (L-OHP) is a major barrier in the treatment of colorectal cancer (CRC). Autophagy is the main cause of L-OHP tolerance in CRC cells.
Weijun Liu +6 more
doaj +1 more source
Apoptosis of HCT116 cells is downregulated after OSM stimulation.
, 2014 Treatment with OSM (10 ng/mL and 100 ng/mL) for 6 hours significantly reduced caspase-3/7 activity (* p = 0.03; **p = 0.02, respectively) compared to unstimulated HCT116 cells. TNF-α (50 ng/mL) served as positive control (# p = 0.007 vs.
Florian Beigel (174724) +6 more
core +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source