Results 101 to 110 of about 4,460,555 (293)
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Drug Delivery, 2018 Hybrid liposomes (HLs) can be prepared by simply sonicating a mixture of vesicular and micellar molecules in a buffer solution. This study aimed to elucidate the therapeutic effects and ability of HLs to detect (diagnosis) cancer in an orthotopic graft ...
Masaki Okumura +2 more
doaj +1 more source
Di-san junyi daxue xuebao, 2019 Objective To investigate the effects of advanced glycation end products (AGEs) on the proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of colon cancer HCT116 cells in hypoxic microenvironment.
WAN Lin +3 more
doaj +1 more source
Overexpression of p67phox in response to fluoropyrimidines in HCT116 cells
, 2016 Objectives: Cancer cells require reactive oxygen species (ROS) in order to keep up with growth rate. The accumulation of ROS induced by anticancer drugs can promote cell death through oxidative damage. A potential source of ROS is the family of NADPH oxidase (NOX) enzyme that produces ROS as their sole function.
Ozer, Ufuk, Barbour, Karen Wood
openaire +2 more sources
Oncotarget, 2017 Δ40p53 is an isoform of wild-type p53 (wtp53). Here, we assessed whether Δ40p53 has the same functions as wild-type p53 in the regulation of cell death and autophagy. First, we used HCT116 (p53+/+) and H1299 (p53-free) cells to produce two cell lines (HCT116-Δ40p53 and H1299-Δ40p53) that express exogenous Δ40p53 but not wtp53. By using these cell lines,
Zang, Yunjin +5 more
openaire +3 more sources
Autophagy is induced in HT29 and HCT116 Bax-ko cells and is reversed after treatment ends.
, 2014 (a) Western blots of LC3, Cleaved PARP, Caspase 3 and α-tubulin in control HCT116 Bax-ko cells and in 10 μM or 20 μM PI-103-treated or 6 hr and 24 hr HBSS-treated HCT116 Bax-ko cells.
Harry G. Parkes (542378) +10 more
core +1 more source
, 2023 (A-F) Nothern blots of RNA extracts from HeLa, HCT116 p53+ and HCT116 p53- cells with knockdown or overexpression of SURF6 and from control cells. Membranes were hybridized with biotinylated ITS1, ITS2 and 7SK (used for loading control and normalization)
Kira Dobrochaeva (16548428) +9 more
core +1 more source
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
NIBP knockdown increases cell motility and invasion in HCT116 cells in vitro.
, 2017 Motility and invasion capability of control un-transfected and NC transfected HCT116 cells as well as NIBP knockdown HCT116 cells with or without TNF-α treatment.
Mengbin Qin (3710482) +6 more
core +1 more source
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source