Advanced Science, Volume 13, Issue 33, 15 June 2026.The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang +7 more
wiley +1 more source
Gallium Metal-Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells. [PDF]
Int J Nanomedicine, 2023 Wu YY +8 more
europepmc +1 more source
AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics
Aggregate, Volume 7, Issue 6, June 2026.In CRC, TPA‐FB directly binds to STAT3 and blocks its phosphorylation. It reduces SUCLG2 expression, disrupts mitochondrial function and modulates protein succinylation. Our work highlights that targeting oncogenic STAT3, TPA‐FB rewires metabolism and inhibits CRC progression.
Shaomin Zou +12 more
wiley +1 more source
Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells. [PDF]
Oncotarget, 2023 Juchem ALM +9 more
europepmc +1 more source
Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1626-1646, June 2026.ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara +5 more
wiley +1 more source
3β-Hydroxy-12-oleanen-27-oic Acid Exerts an Antiproliferative Effect on Human Colon Carcinoma HCT116 Cells via Targeting FDFT1. [PDF]
Int J Mol Sci, 2023 Tu J +5 more
europepmc +1 more source
FKBP9 Enhances Colon Cancer Cell Proliferation by Inhibiting GPX4‐Mediated Ferroptosis
Cancer Medicine, Volume 15, Issue 6, June 2026.The significance of FKBP9 as a therapeutic target in colon cancer treatment, providing new avenues for strategies aimed at sensitizing cancer cells to ferroptosis and improving patient outcomes. ABSTRACT Colorectal cancer, a major health issue worldwide, exhibits intricate molecular mechanisms that necessitate further exploration, particularly ...
Jianzhong Deng +6 more
wiley +1 more source
Exploring the Apoptotic-Induced Biochemical Mechanism of Traditional Thai Herb (Kerra™) Extract in HCT116 Cells Using a Label-Free Proteomics Approach. [PDF]
Medicina (Kaunas), 2023 Siriwaseree J +6 more
europepmc +1 more source
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li +5 more
wiley +1 more source
Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. [PDF]
Sci Rep, 2023 Robson JL +4 more
europepmc +1 more source