Results 121 to 130 of about 4,460,555 (293)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

STR profiles of HCT116^NIH and HCT116^UCL cell-lines, compared with HCT116 cells curated at ATCC.

, 2016
The loci for eight core short tandem repeats plus Amelogenin were derived by ATCC for their curated HCT116 cell line (catalogue number CCL-247) and the HCT116NIH and HCT116UCL cells.
Chunfang Gu (245490), Adolfo Saiardi (263859), Stephen B. Shears (528105), Henning J. Jessen (1500052), Miranda S. C. Wilson (3280074)   +4 more
core   +1 more source

p53 contributes to the chemotherapeutic drug doxorubicininduced cell death in colorectal cancer cell line HCT116 [PDF]

BIO Web of Conferences
Doxorubicin is a commonly used chemotherapy drug for cancer treatment, but its effectiveness varies across different cancer types. p53 is a key factor involved in cell death induced by therapeutic agents.
Deng Rui
doaj   +1 more source

Global transcript profiles in HCT116^p53+/+ and HCT116^p53−/− cells in response to Inauhzin treatment.

, 2013
(A) Inauhzin (INZ) increased p21 and mdm2 mRNA in HCT116p53+/+, but not in HCT116 p53−/−, cells. Cells were treated with 4 µM INZ for 18 hours and harvested for RT-PCR. RT-PCR products of actin were used as an internal control. (B) Overview of the entire
Shelya X. Zeng (292599), Jun-Ming Liao (215004), Xiang Zhou (164107), Hua Lu (240206)   +3 more
core   +1 more source

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

Cancer & Metabolism, 2019
Background Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-ketoglutarate ...
Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap, William P. J. Leenders   +10 more
doaj   +1 more source

Viability of human colorectal cancer cells HCT116, and other types of cancer cells or normal cells.

, 2018
Viability of human colorectal cancer cells HCT116, and (B) other types of cancer cells or normal cells at fifth day from transfection with miR-8073 mimic or negative control sequence (miR-NC).
Aiko Takayama (6160544), Taiga Arai (6160547), Hiroko Sudo (121176), Atsuko Mizoguchi (183957), Junpei Kawauchi (183959)   +4 more
core   +1 more source

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

Journal of Translational Medicine, 2012
Background Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent.
Caporali Simona, Levati Lauretta, Graziani Grazia, Muzi Alessia, Atzori Maria Grazia, Bonmassar Enzo, Palmieri Giuseppe, Ascierto Paolo A, D’Atri Stefania   +8 more
doaj   +1 more source

Part of genes affected by miR-147 in HCT116 cells.

, 2014
Part of genes affected by miR-147 in HCT116 cells.
Chang Gong Lee (509341), Susan McCarthy (509342), Cindy Timme (509344), Mike Gruidl (509343), Timothy J. Yeatman (509345)   +4 more
core   +1 more source

Evaluation of CYP11Bs expression in HCT116 cells [PDF]

TAP CHI SINH HOC, 2012
Nguyen Huy Hoang, Rita Bernhardt
openaire   +1 more source