Phenotypic profiling of small molecules using cell painting assay in HCT116 colorectal cancer cells
PLOS OneUnderstanding how small molecules affect cellular morphology is essential for exploring their mechanisms of action (MoA) and identifying new therapeutic candidates. In this study, the Cell Painting Assay (CPA) was used to profile 196 small molecules in HCT116 colorectal cancer cells.
Velemir Lavrinenko +5 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 32, 9 June 2026.The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia +15 more
wiley +1 more source
Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II). [PDF]
Int J Mol Sci, 2023 Nakamura M +5 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells. [PDF]
Int J Mol Sci, 2023 Shah JA +8 more
europepmc +1 more source
The Changes of Expression of Survivin by Butyrate in HCT116 Colon Cancer Cells
Journal of the Korean Surgical Society, 2009 Purpose: The causes of colon cancer can be divided into genetic and environmental components. A high-fiber diet is known to reduce the risk of colon cancer. Dietary fiber is converted to short chain fatty acid, butyrate, in the colon by bacteria. Butyrate is used as an energy source for the colonic epithelial cells, and is known to induce apoptosis in ...
openaire +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan +13 more
wiley +1 more source
Butyrate-mediated Resistance to Trichostatin A Accompanied by Elevated Expression of Glucose Transporter 3 (GLUT3) in Human Colorectal Carcinoma HCT116 Cells. [PDF]
Asian Pac J Cancer Prev, 2023 Khonthun C, Surangkul D.
europepmc +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang +10 more
wiley +1 more source
Erratum: [Corrigendum] Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells. [PDF]
Oncol Lett, 2023 Wang H +5 more
europepmc +1 more source