Results 111 to 120 of about 4,460,555 (293)
Data showing the circumvention of oxaliplatin resistance by vatalanib in colon cancer
Data in Brief, 2016 We have recently reported that vatalanib, an orally active small molecule multi-tyrosine kinase inhibitor (Hess-Stumpp et al., 2005 [1]), can sensitize multidrug resistant (MDR) colon cancer cells to chemotherapy under hypoxia by inhibiting two MDR ...
Kenneth K.W. To +5 more
doaj +1 more source
Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents
Journal of Traditional Chinese Medical Sciences, 2020 Background: N-Alkylamides (NAAs), derived from Anacyclus pyrethrum (L.) DC, have potential anti-tumor effects. To explore the molecular mechanism and chemo-preventive capacity of NAAs, we synthesized an NAA (H-10) and evaluated whether it could inhibit ...
Kunxiu Jiang +8 more
doaj +1 more source
CIP2A is required for growth of HCT116 cells.
, 2013 (A) Immunoblot analysis of CIP2A and c-Myc protein expression in HCT116 cells infected lentiviral with shRNA targeting CIP2A or a ctr. shRNA. Numbers below lines indicate the c-myc protein expression relative to c-myc levels in control cells (n = 2). (B)
Uwe Mäder (465132) +9 more
core +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang +3 more
wiley +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells
International Journal of Oncology, 2017 Colorectal cancer (CRC) is the second leading cause of cancer death. Hence, there is a great need to explore new efficacious drugs for the treatment of CRC. Honokiol (HNK), a natural product extracted from magnolia bark, processes various biological activities, including anticancer.
Rong-Xing, Liu +9 more
openaire +3 more sources
, 2017 (A) Confirmation of knockdown functionality by qRT-PCR and calcium imaging experiments. M = Marker. Stimulation of HCT116/EV (left) and HCT116/10F1 cells (right) with Troenan (100 μM/ 300 μM).
Stephan Hahn (534868) +8 more
core +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Unacetylated CDC42 K153 is correlated with enhanced tumorigenesis phenotype of HCT116 cells.
, 2023 HCT116 cells stably expressing CDC42-WT, CDC42 K153Q or CDC42 K153R were analyzed for apoptosis as followed: (A) The level of full-length or cleaved caspase-3 or PARP in cells treated with 4 μM staurosporine (STS) for 4 h was determined by WB.
Jian-Hui Li (2570410) +8 more
core +1 more source