Results 191 to 200 of about 47,486 (225)

Live cell catapulting and recultivation does not change the karyotype of HCT116 tumor cells

Cancer Genetics and Cytogenetics, 2005
We used laser microdissection and pressure catapulting (LMPC) to isolate and subsequently recultivate cells from the colorectal cancer cell line HCT116. Cell isolation and recultivation was repeated 5 times from the preceding cell culture. The chromosomal composition of the HCT116 cells was analyzed at the beginning and after each recultivation. We did
Sabine, Langer, Jochen B, Geigl, Susanne, Ehnle, Rainer, Gangnus, Michael R, Speicher   +4 more
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HCT116 cell line heterogeneity: A useful tool for preclinical research

Chemico-Biological Interactions
Cancer cell heterogeneity is one of the reasons for anticancer chemotherapy failure. Nowadays, this field of research is receiving increasing attention, but mainly as a descriptive characteristic of the tumor. In this study, the property of heterogeneity of tumor colonies is considered as the basis for the identification of effective treatment schemes.
Tatyana A. Grigoreva, Aleksandra V. Sagaidak, Daria N. Kindt, Anastasiya D. Zenina, Angelina A. Romanova, Gleb S. Ivanov, Tatyana K. Yakovleva, Viktoriya I. Turilova, Vyacheslav G. Tribulovich   +8 more
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Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells

Journal of Natural Products, 2018
HCT116 colorectal cancer cell sensitivity to peloruside A (PLA) in normoxia is not altered by hypoxia preconditioning of the cells. We examined whether the PLA effects were altered in hypoxia and whether the activity was dependent on p53. The cytotoxicity of PLA in wild-type HCT116 cells was largely unaffected by hypoxia; however, cells in which p53 ...
Jiří Řehulka, Narendran Annadurai, Ivo Frydrych, Petr Džubák, John H. Miller, Marián Hajdúch, Viswanath Das   +6 more
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Dichlorvos-induced toxicity in HCT116 cells: Involvement of oxidative stress and apoptosis

Pesticide Biochemistry and Physiology, 2015
Organophosphorous (OP) pesticides are widely used in the agriculture and home. Among those pesticides, Dichlorvos (DDVP) is a worldwide used insecticide for pest control. DDVP is commonly used as an insecticide for maintenance and growth of agricultural products, to control the internal and external parasites of farm animals, and to eradicate insects ...
Intidhar, Ben Salem, Manel, Boussabbeh, Hassen, Bacha, Salwa, Abid   +3 more
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Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116

Journal of Cellular Biochemistry, 2018
Abstract5‐fluorouracil (5‐FU) and oxaliplatin (OxaPt) are the main chemotherapeutics for colorectal cancer (CRC). Chemotherapy response rates for advanced CRC remain low, primarily due to intrinsic or acquired chemoresistance. The importance of Notch and Wnt signaling for carcinogenesis of CRC as well as crosstalk of Notch and Wnt signaling with many ...
Egle Kukcinaviciute, Violeta Jonusiene, Ausra Sasnauskiene, Daiva Dabkeviciene, Eigile Eidenaite, Arvydas Laurinavicius   +5 more
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[Suppression of HCT116 growth of cells by Gadd45].

Zhonghua yi xue za zhi, 2004
To study the mechanism of suppression of growth of HCT116 human colon carcinoma cells by Gadd45 gene.HCT116 human colon carcinoma cells were transfected with pTRE-Gadd45 vector so as to establish Gadd45-inducible cell line that was cultured in medium with tetracycline. Then tetracycline was withdrawn. The number of cell clones was counted.
Tong, Tong, Yong-mei, Song, Ming, Fu, Li-jia, Dong, Shun-qian, Jin, Min, Wu, Qi-min, Zhan   +6 more
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Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells

Bioorganic & Medicinal Chemistry, 2012
Coumarins and coumarin derivatives as well as diallyl polysulfides are well known as anticancer drugs. In order to find new drugs with anticancer activities, we combined coumarins with polysulfides in the form of di-coumarin polysulfides. These novel compounds were tested in the HCT116 colorectal cancer cell line.
Nathaniel Edward Bennett Saidu, VALENTE, Sergio, Emilie Bana, Gilbert Kirsch, Denyse Bagrel, Mathias Montenarh   +5 more
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Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line

Molecular and Cellular Biochemistry, 2011
Dihydroartemisinin (DHA) is an important artemisinin derivative and presents profound anti-tumor potential. A DHA-resistant cell line named HCT116/R derived from colon carcinoma cell line HCT116 was established in our previous study. Herein, we found that HCT116/R cells were much more resistant to DHA- or artesunate-induced proliferation inhibition and
Jin-Jian, Lu, Si-Meng, Chen, Jian, Ding, Ling-Hua, Meng   +3 more
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Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

Mechanisms of Ageing and Development, 2009
Induction of senescence has been proposed as a possible in vivo tumor response to anticancer treatment. Senescent cancer cells are often polyploid, however, their route to polyploidy is poorly recognized (endoreduplication versus aberrant mitoses).
Malgorzata A, Sliwinska, Grazyna, Mosieniak, Kamila, Wolanin, Aneta, Babik, Katarzyna, Piwocka, Adriana, Magalska, Joanna, Szczepanowska, Jan, Fronk, Ewa, Sikora   +8 more
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Characteristics of Apoptosis in HCT116 Colon Cancer Cells Induced by Deoxycholic Acid

The Journal of Biochemistry, 2005
Hydrophobic bile acids induce apoptosis in both colon cancer cells and hepatocytes. The mechanism by which colon cancer cells respond to bile acids is thought to be different from that of hepatocytes. Therefore, we investigated the characteristics of apoptosis in colon cancer cell line HCT116.
Satoko, Yui, Tohru, Saeki, Ryuhei, Kanamoto, Kimikazu, Iwami   +3 more
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