Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. [PDF]
Sci Rep, 2023 Robson JL +4 more
europepmc +1 more source
Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad +4 more
wiley +1 more source
Integrated Profiles of Transcriptome and mRNA m6A Modification Reveal the Intestinal Cytotoxicity of Aflatoxin B1 on HCT116 Cells. [PDF]
Genes (Basel), 2022 Wu Y +6 more
europepmc +1 more source
Effect of oxaliplatin on HCT116 P53+/- colon cancer cells
, 2011 Oxaliplatin as an effective chemotherapeutic agent in FOLFOX regimens is using to treat colorectal cancer. In this study we investigate cytotoxicity of Oxaliplatin as single chemotherapeutic agent toHCT116P53+/- to identify molecular mechanism of Oxaliplatin action in induction of apoptosis pathway.
openaire +1 more source
Quercetin and 5-Fu Loaded Chitosan Nanoparticles Trigger Cell-Cycle Arrest and Induce Apoptosis in HCT116 Cells via Modulation of the p53/p21 Axis. [PDF]
ACS Omega, 2023 Das S +5 more
europepmc +1 more source
Microarray dataset supporting a role for ATF4 in isoginkgetin-induced gene expression in HCT116 cells. [PDF]
Data Brief, 2022 van Zyl E, Tolls V, McKay BC.
europepmc +1 more source
Inositol pyrophosphate kinases in health and disease
FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid RPE1 and HCT116 cells. [PDF]
BMC Genomics, 2023 Mabuchi A +10 more
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, Volume 600, Issue 17, Page 2420-2436, September 2026.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC. [PDF]
Exp Biol Med (Maywood), 2022 Huang Y +7 more
europepmc +1 more source