LMTK2 Inhibits Metastasis of Colon Cancer Cells Through p38 MAPK
Cancer Science, EarlyView.LMTK2 suppresses colon cancer metastasis by acting as a kinase‐independent scaffold that directly binds p38, blocking its interaction with MKK3/6 and subsequent phosphorylation, thereby inhibiting the downstream pro‐metastatic gene program. ABSTRACT Metastasis is the leading cause of death in patients with colon cancer. Although Lemur tyrosine kinase 2
Jie Lun +6 more
wiley +1 more source
Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells. [PDF]
Oncotarget, 2023 Juchem ALM +9 more
europepmc +1 more source
The response of chemoresistant human colorectal cancer cells HCT116 to cytotoxic treatment. [PDF]
, 2019 The intrinsic or acquired drug resistance is one of the culprits leading to the failure of colorectal cancer (CRC) treatment. In this study, the importance of autophagy and Wnt/β-catenin, Notch1 signaling pathways for the response of human CRC cells ...
Kukcinavičiūtė, Eglė,
core
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
3β-Hydroxy-12-oleanen-27-oic Acid Exerts an Antiproliferative Effect on Human Colon Carcinoma HCT116 Cells via Targeting FDFT1. [PDF]
Int J Mol Sci, 2023 Tu J +5 more
europepmc +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
Exploring the Apoptotic-Induced Biochemical Mechanism of Traditional Thai Herb (Kerra™) Extract in HCT116 Cells Using a Label-Free Proteomics Approach. [PDF]
Medicina (Kaunas), 2023 Siriwaseree J +6 more
europepmc +1 more source
Host–Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer
Molecular Oral Microbiology, Volume 41, Issue 5, Page 258-265, October 2026.Fusobacterium nucleatum and colorectal cancer. ABSTRACT The oral‐derived pathobiont Fusobacterium nucleatum has increasingly been implicated in colorectal cancer (CRC) progression through its ability to modulate inflammatory, immunological, and molecular pathways. F.
Hadda Lyzandra Austríaco Leite +1 more
wiley +1 more source
The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells. [PDF]
Int J Mol Sci, 2023 Wu T +11 more
europepmc +1 more source
ChemMedChem, Volume 21, Issue 17, 14 September 2026.An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis +16 more
wiley +1 more source