Results 31 to 40 of about 276,656 (346)

Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection.

New England Journal of Medicine, 2014
BACKGROUND All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated daclatasvir (an HCV NS5A replication complex inhibitor) plus sofosbuvir (a nucleotide analogue HCV NS5B polymerase inhibitor ...
M. Sulkowski, D. Gardiner, M. Rodríguez-Torres, K. R. Reddy, Tarek Hassanein, Ira M. Jacobson, E. Lawitz, Anna S. Lok, F. Hinestrosa, P. Thuluvath, Howard Schwartz, David R. Nelson, Gregory T. Everson, T. Eley, M. Wind-Rotolo, Shu‐Pang Huang, Min Gao, D. Hernandez, F. Mcphee, D. Sherman, R. Hindes, W. Symonds, Claudio Pasquinelli, D. Grasela   +23 more
semanticscholar   +1 more source

Feasibility of anti-HCV reflex HCV Ag screening strategy in an HCV endemic community

Journal of the Formosan Medical Association, 2021
The HCV core antigen (HCV Ag) assay displays high sensitivity and strong correlation with HCV RNA. However, the feasibility of anti-HCV reflex HCV Ag screening in a community-wide setting is rarely discussed.We performed a two-phase community-based hepatitis C screen in an HCV-prone area of central Taiwan.
Wei-Ming Chen, Chih-Yi Lee, Nien-Tzu Hsu, Wei-Cheng Huang, Mei-Yen Chen, Tung-Jung Huang, Sheng-Nan Lu   +6 more
openaire   +5 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Sero-prevalence and risk factors of hepatitis C virus infection among pregnant women in Bahir Dar city, Northwest Ethiopia: cross sectional study

The Pan African Medical Journal, 2015
Viral hepatitis during pregnancy is associated with high risk of maternal complications and has become a leading cause of foetal death. So the main objective of this study is to determine the prevalence of hepatitis C viral infections among pregnant ...
Yohannes Zenebe, Wondemagegn Mulu, Mulat Yimer, Bayeh Abera   +3 more
doaj   +1 more source

Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection.

New England Journal of Medicine, 2014
BACKGROUND Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need.
N. Afdhal, K. Reddy, D. Nelson, E. Lawitz, S. Gordon, E. Schiff, R. Nahass, R. Ghalib, N. Gitlin, R. Herring, J. Lalezari, Z. Younes, P. Pockros, A. D. Di Bisceglie, Sanjeev Arora, G. Subramanian, Yanni Zhu, H. Dvory‐Sobol, Jenny C. Yang, P. Pang, W. Symonds, J. Mchutchison, A. Muir, M. Sulkowski, P. Kwo   +24 more
semanticscholar   +1 more source

HBV and HCV Therapy [PDF]

Viruses, 2009
One year of interferon therapy inhibits HBV replication in one third of the patients whereas long-term administration of oral nucleos(t)ide analogues is efficient in most of them, as long as early treatment adaptation in patients with partial virological response and resistance is provided.
P. Lampertico, A. Aghemo, M. Viganò, M. Colombo   +3 more
openaire   +4 more sources

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Gastroenterology, 2019
BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR)
Nourdine Hamdane, Frank Jühling, E. Crouchet, Houssein El Saghire, C. Thumann, Marine A. Oudot, S. Bandiera, Antonio Saviano, C. Ponsolles, A. A. Roca Suarez, Shen Li, N. Fujiwara, A. Ono, I. Davidson, N. Bardeesy, Christian Schmidl, C. Bock, C. Schuster, J. Lupberger, F. Habersetzer, M. Dofföel, T. Piardi, D. Sommacale, M. Imamura, Takuro Uchida, H. Ohdan, H. Aikata, K. Chayama, T. Boldanova, P. Pessaux, B. Fuchs, Y. Hoshida, M. Zeisel, F. Duong, T. Baumert   +34 more
semanticscholar   +1 more source

HCV avidity as a tool for detection of recent HCV infection: Sensitivity depends on HCV genotype [PDF]

Journal of Medical Virology, 2017
Accurate detection of incident hepatitis C virus (HCV) infection is required to target and evaluate public health interventions, but acute infection is largely asymptomatic and difficult to detect using traditional methods. Our aim was to evaluate a previously developed HCV avidity assay to distinguish acute from chronic HCV infection.
Samantha J. Shepherd, Scott A. McDonald, Tanya L. Applegate, Norah Palmateer, Behzad Hajarizadeh, David J. Goldberg, David J. Goldberg, Andrew R. Lloyd, Rory Gunson, Sharon J. Hutchinson, Sharon J. Hutchinson, Jason Grebely, Gregory J. Dore, Celia Aitken   +13 more
openaire   +4 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source