Results 31 to 40 of about 273,364 (223)

Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.

New England Journal of Medicine, 2015
BACKGROUND In phase 2 trials, treatment with the combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor velpatasvir resulted in high rates of sustained virologic response in patients chronically infected with hepatitis C ...
G. Foster, N. Afdhal, S. Roberts, N. Bräu, E. Gane, S. Pianko, E. Lawitz, A. Thompson, M. Shiffman, C. Cooper, W. Towner, B. Conway, P. Ruane, M. Bourliere, T. Asselah, T. Berg, S. Zeuzem, W. Rosenberg, K. Agarwal, C. Stedman, H. Mo, H. Dvory‐Sobol, Lingling Han, Jing Wang, J. McNally, A. Osinusi, D. Brainard, J. Mchutchison, F. Mazzotta, T. Tran, S. Gordon, K. Patel, N. Reau, A. Mangia, M. Sulkowski   +34 more
semanticscholar   +1 more source

The R Package HCV for Hierarchical Clustering from Vertex-links [PDF]

arXiv, 2022
The HCV package implements the hierarchical clustering for spatial data. It requires clustering results not only homogeneous in non-geographical features among samples but also geographically close to each other within a cluster. We modified typically used hierarchical agglomerative clustering algorithms to introduce the spatial homogeneity, by ...
arxiv  

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Gastroenterology, 2019
BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR)
Nourdine Hamdane, Frank Jühling, E. Crouchet, Houssein El Saghire, C. Thumann, Marine A. Oudot, S. Bandiera, Antonio Saviano, C. Ponsolles, A. A. Roca Suarez, Shen Li, N. Fujiwara, A. Ono, I. Davidson, N. Bardeesy, Christian Schmidl, C. Bock, C. Schuster, J. Lupberger, F. Habersetzer, M. Dofföel, T. Piardi, D. Sommacale, M. Imamura, Takuro Uchida, H. Ohdan, H. Aikata, K. Chayama, T. Boldanova, P. Pessaux, B. Fuchs, Y. Hoshida, M. Zeisel, F. Duong, T. Baumert   +34 more
semanticscholar   +1 more source

An optimal control approach for the treatment of hepatitis C patients [PDF]

arXiv, 2023
In this article, the feasibility of using optimal control theory will be studied to develop control theoretic methods for personalized treatment of HCV patients. The mathematical model for HCV progression includes compartments for healthy hepatocytes, infected hepatocytes, infectious virions and noninfectious virions.
arxiv  

Evaluate the prevalence of CCP and RF antibodies as a marker for diagnosis and progression of Rheumatoid Arthritis disease and assess the prevalence of HCV in RA patients [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2014
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by the presence of autoantibodies like rheumatoid factor (RF). In the last few years, several other autoantibodies have been described of which anti-cyclic citrullinated
Qabas R. Ali, Mohammad Q. Alani, Hanaa N. Abdallha, Salim Obaid Al Mawla   +3 more
doaj   +1 more source

Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.

New England Journal of Medicine, 2014
BACKGROUND High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor ledipasvir ...
K. Kowdley, S. Gordon, K. Reddy, L. Rossaro, D. Bernstein, E. Lawitz, M. Shiffman, E. Schiff, R. Ghalib, M. Ryan, V. Rustgi, M. Chojkier, R. Herring, A. D. Di Bisceglie, P. Pockros, G. Subramanian, D. An, E. Svarovskaia, R. Hyland, P. Pang, W. Symonds, J. Mchutchison, A. Muir, D. Pound, M. Fried   +24 more
semanticscholar   +1 more source

The efficiency and safety of anti-Helicobacter pylori therapy in patients with concomitant chronic hepatitis C [PDF]

Терапевтический архив, 2016
Aim. To evaluate the efficiency and safety of two eradication therapy (ET) regimens for Helicobacter pylori infection in patients with concomitant chronic hepatitis C (CHC) in relation to the stage of liver fibrosis (LF). Subjects and methods.
D N Andreev, I V Maev, Yu A Kucheryavyi, D T Dicheva, E V Partsvania-vinogradova   +4 more
doaj  

Telaprevir for retreatment of HCV infection.

New England Journal of Medicine, 2011
BACKGROUND Up to 60% of patients with hepatitis C virus (HCV) genotype 1 infection do not have a sustained virologic response to therapy with peginterferon alfa plus ribavirin.
S. Zeuzem, P. Andreone, S. Pol, E. Lawitz, M. Diago, S. Roberts, R. Focaccia, Z. Younossi, G. Foster, A. Horban, P. Ferenci, F. Nevens, B. Müllhaupt, P. Pockros, R. Terg, D. Shouval, B. van Hoek, O. Weiland, R. V. van Heeswijk, S. De Meyer, D. Luo, G. Boogaerts, R. Polo, G. Picchio, M. Beumont   +24 more
semanticscholar   +1 more source

HIV dynamics and natural history studies: Joint modeling with doubly interval-censored event time and infrequent longitudinal data [PDF]

Annals of Applied Statistics 2011, Vol. 5, No. 1, 400-426, 2011
Hepatitis C virus (HCV) coinfection has become one of the most challenging clinical situations to manage in HIV-infected patients. Recently the effect of HCV coinfection on HIV dynamics following initiation of highly active antiretroviral therapy (HAART) has drawn considerable attention.
arxiv   +1 more source

Burden and Transmission Risks of Viral Hepatitis in Southern Ethiopia: Evidence Needed for Prevention and Control Measures

Risk Management and Healthcare Policy, 2021
Gizachew Beykaso,1,2 Andargachew Mulu,3 Mirutse Giday,1 Nega Berhe,1 Markos Selamu,2 Adane Mihret,3 Tilahun Teklehaymanot1 1Department of Molecular Biology and Immunology, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa ...
Beykaso G, Mulu A, Giday M, Berhe N, Selamu M, Mihret A, Teklehaymanot T   +6 more
doaj