Results 11 to 20 of about 210,178 (301)

Multiscale Modeling of an 8-Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection. [PDF]

Clin Pharmacol Ther
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Zitzmann C, Ribeiro RM, Marc A, Zhou XJ, Perelson AS.   +4 more
europepmc   +2 more sources

HCV and Lymphoproliferation [PDF]

Clinical and Developmental Immunology, 2012
Hepatitis C virus (HCV) infection is a serious public health problem because of its worldwide diffusion and sequelae. It is not only a hepatotropic but also a lymphotropic agent and is responsible not only for liver injury—potentially evolving to cirrhosis and hepatocellular carcinoma—but also for a series of sometimes severely disabling extrahepatic ...
ZIGNEGO, ANNA LINDA, GIANNINI, CARLO, GRAGNANI, LAURA   +2 more
openaire   +6 more sources

Screening for HCV [PDF]

Canadian Medical Association Journal, 2014
We agree with Shah and colleagues[1][1] that the growing burden of chronic hepatitis C virus (HCV) infection poses a substantial public health concern. Managing HCV is difficult, because HCV is clinically silent for the majority of those infected.
William W L, Wong, Murray, Krahn
openaire   +5 more sources

Chronic HCV Infection: Clinical Advances and Eradication Perspectives [PDF]

, 2022
Hepatitis C virus (HCV) chronic infection can determine liver fibrosis, cirrhosis and hepatocellular carcinoma, as well as several extra-hepatic manifestations (i.e., mixed cryoglobulinemia, metabolic syndrome, kidney disease, etc.).

core   +1 more source

A hepatitis C avidity test for determining recent and past infections in both plasma and dried blood spots [PDF]

, 2013
DBS testing has been used successfully to detect HCV antibody positive individuals. Determining how long someone has been infected is important for surveillance initiatives. Antibody avidity is a method that can be used to calculate recency of infection.
Hutchinson, Sharon, Goldberg, David J., Keen, Joy, Aitken, Celia, Shepherd, Samantha J., Gunson, R.N., Cameron, Sheila O., Carman, W.   +7 more
core   +4 more sources

HCV treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals. [PDF]

, 2013
UNLABELLED: Substantial reductions in hepatitis C virus (HCV) prevalence among people who inject drugs (PWID) cannot be achieved by harm reduction interventions such as needle exchange and opiate substitution therapy (OST) alone. Current HCV treatment is
Dillon, John, Hellard, M, Grebely, J ; https://orcid.org/, Hellard, Margaret, Goldberg, David J., Martin, Natasha K, Goldberg, DJ, Vickerman, P, Dore, Gregory J, Goldberg, David, Hickman, M ; https://orcid.org/, Hickman, Matthew, Lima, Viviane D, Grebely, J, Hutchinson, SJ, Dillon, John F.; id_orcid, Foster, Graham R., Lima, Viviane, Hickman, M, Martin, Natasha, Hutchinson, Sharon J.; id_orcid, Lima, VD, Martin, NK, Dore, Gregory J., Foster, Graham, Lima, Viviane D., Dore, Gregory, Vickerman, Peter, Goldberg, David J, Dillon, John F, Grebely, Jason, Hutchinson, Sharon, Hutchinson, Sharon J., Foster, Graham R, Dillon, JF, Dore, GJ ; https://orcid.org/, Foster, GR, Dillon, John F., Dore, GJ, Hutchinson, Sharon J, Martin, Natasha K.   +40 more
core   +1 more source

HCV and the kidney [PDF]

Liver International, 2016
AbstractChronic hepatitis C (CHC) is significantly associated with a risk of renal deterioration over time. Renal impairment, especially stage 4–5 chronic kidney disease, increases the risk of: (i) the prevalence and incidence (in dialysis/transplantation) of hepatitis C virus (HCV) infection; (ii) liver deterioration during kidney transplantation and (
Marion, Corouge, Anaïs, Vallet-Pichard, Stanislas, Pol   +2 more
openaire   +2 more sources

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

HCV core antigen and HCV-RNA in HIV/HCV co-infected patients with different HCV genotypes [PDF]

BMC Infectious Diseases, 2014
A good correlation between HCV core antigen (HCVAg) and different HCV-RNA assays has been described, but little data are available in HCV/HIV co-infection. We aimed to evaluate HCVAg in comparison with HCV-RNA and to determine their kinetics during antiviral treatment in selected HCV/HIV co-infected patients.355 samples from 286 HCV/HIV co-infected ...
Garbuglia, Anna Rosa, Monachetti, Alessia, Galli, Claudio, Sabatini, Rosella, Ferreri, Monica Lucia, Capobianchi, Maria Rosaria, Bagnarelli, Patrizia   +6 more
openaire   +2 more sources

Hepatocellular Carcinoma Post Direct Anti Hepatitis C Viral Agents; Clinical Features [PDF]

African Journal of Gastroenterology and Hepatology, 2022
Background:Direct Anti Hepatitis C Viral Agents (DAAs) were introduced for Hepatitis C Virus (HCV) infection management, which resulted in high sustained virological response (SVR) in many countries and a low failure rate.
Nabila Ahmed, Amira Elwan, Essam Abdelrahman, Ahmed Embaby, Ahmed Mohammed   +4 more
doaj   +1 more source