Results 201 to 210 of about 116,207 (325)

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Effective Non-Invasive Delivery of Epigenetic Drugs Using Functionalized Accessory Unit Conjugates. [PDF]

Pharmaceutics
Tashima T.
europepmc   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Design, synthesis and activity evaluation of arctigenin derivatives with HDAC inhibition activity

Xinyue Jiang, Yuchao Yan, Huali Yang, Maosheng Cheng, Deqiang Dou, Yang Liu   +5 more
openalex   +2 more sources

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

Food Frontiers, Volume 7, Issue 2, March 2026.
Auricularia auricula polysaccharides (AAP; 100, 200, and 400 mg/kg) protect against acute lung injury (ALI) by dose‐dependently remodeling the gut microbiota and modulating associated metabolic pathways via the gut‐lung axis, thereby enhancing pulmonary anti‐inflammatory and antioxidant capacity to ultimately prevent tissue damage.
Haili Niu, Fangjia Zhao, Qi Wang, Min Li, Yuan Li, Ivan Kurtovic, Zitong Zhang, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source

Histone and non-histone (de)acetylation impact on the blood-brain barrier. [PDF]

Fluids Barriers CNS
Melo M, Fortuna A, Laranjinha J, Bicker J.   +3 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Polygonum cognatum Extract: Multitarget Anti‐inflammatory, Antidiabetic, and Epigenetic Modulation Properties [PDF]

ChemistryOpen
Polygonum cognatum extracts exhibit strong antioxidant, anti‐inflammatory, antidiabetic, and antimicrobial activities. This study demonstrates, for the first time, histone deacetylase inhibitory activity, revealing epigenetic modulation potential.
Karaman S, Budak Y, Bozdemir E.
europepmc   +2 more sources

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

, 2012
Linda Marek, Alexandra Hamacher, Finn K. Hansen, Krystina Kuna, Holger Gohlke, Matthias U. Kassack, Thomas Kurz   +6 more
openalex   +1 more source

Histone deacetylase (HDAC) [PDF]

Science-Business eXchange, 2008
  +6 more sources