Results 241 to 250 of about 134,666 (283)

Histone deacetylases in Duchenne muscular dystrophy: a role in the mechanism of disease and a target for inhibition. [PDF]

Clin Epigenetics
Bertoldi M, Albamonte E, Bello L, D'amico A, Masson R, Nigro V, Pane M, Panicucci C, Sframeli M, Ricci F.   +9 more
europepmc   +1 more source

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

Cancer Science, Volume 117, Issue 4, Page 1136-1147, April 2026.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka, Koji Hatano, Shohei Katsuki, Tomohiro Kanaki, Shunsuke Inoguchi, Masaru Tani, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Keisuke Tamari, Bangzhong Lin, Akiyoshi Tani, Kazutake Tsujikawa, Yutaka Takahashi, Kazuhiko Ogawa, Shawn E. Lupold, Norio Nonomura   +26 more
wiley   +1 more source

Epigenetic Regulators as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancers (Basel)
Kubiak K, Inkielewicz-Stępniak I.
europepmc   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, Volume 111, Issue 4, Page 1733-1745, 1 April 2026.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

Emerging Molecular Insights and Therapeutic Directions in Neurofibromatosis Type 1 and NF2-Related Schwannomatosis. [PDF]

Int J Mol Sci
Park S, Woo TG, Kang SM, Kim BH, Park BJ.   +4 more
europepmc   +1 more source

Sex‐ and skeletal muscle‐specific gene expression response of histone 3 lysine 27‐modifying enzymes by voluntary running in mice

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Skeletal muscle is highly plastic and capable of remodeling its contractile and metabolic properties depending on physical demands. Such remodeling requires modification of chromatin structure to support transcriptional activation and repression of gene programs. Chromatin dynamics depend, in part, on the acetylation and methylation of histone
Daniel Gamu, Makenna Cameron, Yasmeen Jalil, Imen Zouaoui, Jada Sangha, Jonathan Kim   +5 more
wiley   +1 more source

Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β‐Hydroxybutyrate Signaling and Chromatin Remodeling

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Repeated intermittent fasting elevates hippocampal β‐hydroxybutyrate (BHB), remodels HDAC activity and histone acetylation, and drives a metabolic–epigenetic transition from transient chromatin priming after a single fast to a sustained cytoprotective program associated with reduced DNA damage and enhanced genome maintenance.
Hadar Parnas, Joanna Bartman, Tali Rosenberg, Ronit Yosofov, Noa Gabsi, Asaf Marco   +5 more
wiley   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

Targeting microbiome-driven epigenetic modifications: a new frontier in breast cancer treatment. [PDF]

Clin Epigenetics
Bai Y, Kong X, Wang J.
europepmc   +1 more source