Food Science &Nutrition, Volume 14, Issue 2, February 2026.This study employs an integrative in silico approach combining network pharmacology, molecular docking, and molecular dynamics simulations to explore the molecular association between trigonelline and ovarian aging, identifying five hub proteins (MMP9, JAK2, PARP1, HDAC1, and CYP3A4) and three major mechanistic axes related to extracellular matrix ...
Woon Shin Yong +4 more
wiley +1 more source
Unlocking the therapeutic potential of HDAC8-degrading PROTACs: progress, challenges, and future directions. [PDF]
RSC Med ChemBanerjee S, Adhikari N, Ghosh B.
europepmc +1 more source
Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała +3 more
wiley +1 more source
Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]
Int J Biol SciXu L +10 more
europepmc +1 more source
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery
, 2017 Wei Chen +5 more
openalex +2 more sources
Alterations in Gut Microbiota and Metabolic Profiles in Relapsed or Refractory Lymphoma
MicrobiologyOpen, Volume 15, Issue 1, February 2026.Metabolomic volcano‐heatmap reveals seven upregulated metabolites in relapsed/refractory lymphoma, underscoring gut metabolic reprogramming as a potential therapeutic target. ABSTRACT To identify potential therapeutic strategies for relapsed or refractory lymphoma (R/RL) by examining differences in gut microbiota composition and metabolic profiles ...
Yu‐Ying Guo +5 more
wiley +1 more source
Are HDAC and Glutamine Synthetase Expression Levels Associated with Ga68-DOTATATE PET/CT Data and Prognosis in Gastroenteropancreatic Neuroendocrine Tumours? [PDF]
Medicina (Kaunas)Ulas O +6 more
europepmc +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity. [PDF]
Int J Mol SciSanchez-Michael LA +10 more
europepmc +1 more source