Results 251 to 260 of about 134,666 (283)

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source

SeSA-HCPT: A dual-targeting agent that induces DNA damage and inhibits repair for castration-resistant prostate cancer therapy. [PDF]

iScience
Wang Y, Wang Q, Meng L, Lian X, Wu X, Wang Y, Zhang T, Wei S, Wang Y, Zhu C.   +9 more
europepmc   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling. [PDF]

J Transl Med
Rammah M, Romero AR, Halabi N, Abuaqel S, Guennoun A, Dömling A, Shan J, Chouchane L.   +7 more
europepmc   +1 more source

Genome-wide identification and expression profiling of the histone deacetylase gene family in <i>Fusarium oxysporum</i>. [PDF]

IMA Fungus
Liao HX, Wen JR, Shi HM, Cun HQ, Hong YJ, Hu ZF, Xu FR, Noiprasert S, Apiwongsrichai K, Liu XY, Dong X.   +10 more
europepmc   +1 more source

Isoform-specific vs. pan-histone deacetylase inhibition as approaches for countering glioblastoma: an <i>in vitro</i> study. [PDF]

Front Oncol
Joshi A, Ratnapradipa N, Hughes J, Moore E, Ekpenyong A, Shukla S.   +5 more
europepmc   +1 more source

Chidamide Is Screened to Suppress Epileptogenesis in Mice Models via Blocking Histone Deacetylase 1. [PDF]

CNS Neurosci Ther
Guo Q, Wang ZJ, Dong WB, Pang L, Mao XY.
europepmc   +1 more source

In Vitro and In Vivo Efficacy of Romidepsin Alone and in Addition to Standard of Care for Treatment of Ewing Sarcoma. [PDF]

Cancers (Basel)
Smith KH, Trovillion EM, McKinney KQ, Gourabathini P, Wells K, Gandra D, Sholler C, Votruba I, Oesterheld J, Saulnier Sholler GL.   +9 more
europepmc   +1 more source

High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma. [PDF]

Cancer Biol Ther
Danks MR, Manasterski PJ, Beetham H, Dawson JC, Elliott RJR, Culley J, Krishna R, Muir M, Thomson JP, Oswald AJ, Ewing A, Kerrison WGJ, Huang PH, Nixon I, Carragher NO, Brunton VG.   +15 more
europepmc   +1 more source

Identification of targetable epigenetic vulnerabilities for uveal melanoma. [PDF]

Cell Death Dis
Yenisehirli G, Borges S, Braun SS, Zuniga AN, Quintana GI, Kutsnetsoff JN, Volonterio RL, Rodriguez S, Adis EV, Lopez S, Dollar JJ, Stathias V, Volmar CH, Karaca E, Brothers SP, Bilbao D, Harbour JW, Correa ZM, Kurtenbach S.   +18 more
europepmc   +1 more source