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Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors [PDF]
Pharmaceuticals, 2014 Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders. Emerging studies have demonstrated that different types of HDAC inhibitors show beneficial effects in various experimental ...
Elizabeth Thomas
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Mdm2 is required for HDAC3 monoubiquitination and stability
Biochemical and Biophysical Research Communications, 2019HDAC3, one of the class I histone deacetylase modulates epigenetic landscape through histone modification. HDAC3 also interacts with non-histone proteins including p53 for deacetylation. Moreover, HDAC3 serves as a transcriptional repressor, interacting with NCor1/SMRT complex.
Seunghee Bae, Jinhyuk Jung
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Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90
Cellular Signalling, 2020Deregulated DNA methylation and post-translational histone modifications are majorly associated with cancer progression. Histone modification regulates the gene expression patterns that contribute to the emergence of sporadic cancers. Histone deacetylases (HDACs) act as erasers of acetylation marks, and their functions are often deregulated in cancer ...
Akhil, Kotwal, Sreedhar, Amere Subbarao
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Deacetylase‐dependent and ‐independent role of HDAC3 in cardiomyopathy
Journal of Cellular Physiology, 2023Abstract Cardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac function. HDAC3 commonly functions as corepressor by removing acetyl moieties from histone tails. However, a deacetylase‐independent role of HDAC3 has also been described.
Jieyu, Ren +10 more
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Journal of Cellular Physiology, 2019 The role of histone deacetylase 3 (HDAC3) is to repress the expression of various genes by eliminating acetyl group from histone. Thus, the regulation of HDAC3 activity is essential to maintain cellular homeostasis.
Kyung-Chul Choi +2 more
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The role of HDAC3 in inflammation: mechanisms and therapeutic implications
Frontiers in ImmunologyHistone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions. However, it remains largely unclear how HDACs precisely regulate inflammation.
Sangeetha Sukumari Ramesh
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The Role of HDAC3 in Pulmonary Diseases
LungHistone deacetylases (HDACs), a class of enzymes involved in epigenetic modifications, play a pivotal role in modulating chromatin structure and gene expression. Among these, histone deacetylase 3 (HDAC3) has emerged as a key regulator in diverse cellular pathophysiological processes.
Leyu, Hong +9 more
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2006
Histone deacetylase 3 (HDAC3) is one of four members of the human class I histone deacetylases that repress transcription by deacetylation of histones. This review describes our current knowledge regarding its structure, function, mechanisms of action, and regulation.
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Histone deacetylase 3 (HDAC3) is one of four members of the human class I histone deacetylases that repress transcription by deacetylation of histones. This review describes our current knowledge regarding its structure, function, mechanisms of action, and regulation.
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NKG2D Signaling: The Immune Subversive Side of HDAC3
Trends in Immunology, 2017Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through ...
Alicia R, Folgueras +2 more
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Cloning and Characterization of the Murine Histone Deacetylase (HDAC3)
Biochemical and Biophysical Research Communications, 1999Histone acetylation modifiers have been described to participate as cofactors in mammalian transcriptional complexes involved in the regulation of cellular proliferation and differentiation. The acetylation of core histone proteins is reversible and regulated by two competing enzymatic activities, histone acetyltransferases (HATs) and histone ...
U, Mahlknecht +3 more
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