Results 191 to 200 of about 24,258 (228)

Histone and non-histone (de)acetylation impact on the blood-brain barrier. [PDF]

Fluids Barriers CNS
Melo M, Fortuna A, Laranjinha J, Bicker J.   +3 more
europepmc   +1 more source

Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. [PDF]

JCI Insight
Cashman TJ, Saheera S, Blau AE, Mensah Otabil E, Nagy NY, Samenuk TD, Fitzgibbons TP, McManus DD, Trivedi CM.   +8 more
europepmc   +1 more source

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]

Int J Biol Sci
Xu L, Shen C, Liu X, Qin Y, Wu Z, Zhang Z, Sheng Q, Wang Q, Zhou F, Ge G, Geng D.   +10 more
europepmc   +1 more source

Targeting p300 and CBP abolishes HOXB13-loss-induced lipogenesis and tumor metastasis. [PDF]

JCI Insight
Lu X, Peng L, Chu Q, Ye S, Liu M, Hussain M, Bilen MA, Harik LR, Melamed J, Zhao JC, Yu J.   +10 more
europepmc   +1 more source

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages. [PDF]

FEBS J
Parada-Venegas D, De la Fuente López M, Dubois-Camacho K, Landskron G, Blokzijl T, Molina H, Casanova MC, Cui Y, Liu M, Da Costa De Pina AM, Simian D, González MJ, Weersma RK, Quera R, Dijkstra G, Faber KN, Hermoso MA.   +16 more
europepmc   +1 more source

Dichotomous engagement of HDAC3 activity governs inflammatory responses [PDF]

Nature, 2020
The histone deacetylases (HDACs) are a superfamily of chromatin-modifying enzymes that silence transcription through the modification of histones. Among them, HDAC3 is unique in that interaction with nuclear receptor corepressors 1 and 2 (NCoR1/2) is required to engage its catalytic activity1-3.
Hoang C B Nguyen, Marine Adlanmerini, Amy Hauck   +2 more
exaly   +7 more sources

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Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90

Cellular Signalling, 2020
Deregulated DNA methylation and post-translational histone modifications are majorly associated with cancer progression. Histone modification regulates the gene expression patterns that contribute to the emergence of sporadic cancers. Histone deacetylases (HDACs) act as erasers of acetylation marks, and their functions are often deregulated in cancer ...
Akhil, Kotwal, Sreedhar, Amere Subbarao
openaire   +2 more sources

Microbiota-derived metabolite promotes HDAC3 activity in the gut [PDF]

Nature, 2020
The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of symbiotic host-microbiota relationships1. Epigenetic machinery permits mammalian cells to integrate environmental signals2; however, how these pathways are fine-tuned by diverse cues from commensal bacteria is not well understood.
Vivienne Woo, Jordan Whitt, Lee A Denson
exaly   +3 more sources