Results 201 to 210 of about 24,258 (228)

Deacetylase‐dependent and ‐independent role of HDAC3 in cardiomyopathy

Journal of Cellular Physiology, 2023
Abstract Cardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac function. HDAC3 commonly functions as corepressor by removing acetyl moieties from histone tails. However, a deacetylase‐independent role of HDAC3 has also been described.
Jieyu, Ren, Qun, Zeng, Hongmei, Wu, Xuewen, Liu, Maria C, Guida, Wen, Huang, Yiyuan, Zhai, Junjie, Li, Karen, Ocorr, Rolf, Bodmer, Min, Tang   +10 more
openaire   +2 more sources

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate [PDF]

Nature, 2012
Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails, resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment into multi-subunit co-repressor complexes, which are in turn recruited to chromatin by
Louise Fairall, John W R Schwabe
exaly   +4 more sources

HDAC3 regulates stability of estrogen receptor α mRNA

Biochemical and Biophysical Research Communications, 2013
Estrogen receptor alpha (ERα) expression is a risk factor for breast cancer. HDAC inhibitors have been demonstrated to down-regulate ERα expression in ERα-positive breast cancer cell lines, but the molecular mechanisms are poorly understood. Here, we showed that HDAC inhibitors decrease the stability of ERα mRNA, and that knockdown of HDAC3 decreases ...
Shohei, Oie, Kazuya, Matsuzaki, Wataru, Yokoyama, Akiko, Murayama, Junn, Yanagisawa   +4 more
openaire   +2 more sources

The Role of HDAC3 in Pulmonary Diseases

Lung
Histone deacetylases (HDACs), a class of enzymes involved in epigenetic modifications, play a pivotal role in modulating chromatin structure and gene expression. Among these, histone deacetylase 3 (HDAC3) has emerged as a key regulator in diverse cellular pathophysiological processes.
Leyu, Hong, Ming, Ni, Fei, Xue, Tao, Jiang, Xuanpeng, Wu, Chenxi, Li, Shuhao, Liang, Tianhao, Chen, Chao, Luo, Qifei, Wu   +9 more
openaire   +2 more sources

NKG2D Signaling: The Immune Subversive Side of HDAC3

Trends in Immunology, 2017
Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through ...
Alicia R, Folgueras, Segundo, Gonzalez, Alejandro, López-Soto   +2 more
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Mdm2 is required for HDAC3 monoubiquitination and stability

Biochemical and Biophysical Research Communications, 2019
HDAC3, one of the class I histone deacetylase modulates epigenetic landscape through histone modification. HDAC3 also interacts with non-histone proteins including p53 for deacetylation. Moreover, HDAC3 serves as a transcriptional repressor, interacting with NCor1/SMRT complex.
Yeong Min, Choi, Sungkwan, An, Seunghee, Bae, Jin Hyuk, Jung   +3 more
openaire   +2 more sources

HDAC3 overexpression and colon cancer cell proliferation and differentiation

Molecular Carcinogenesis, 2007
AbstractAn immunohistochemical analysis of human colorectal adenocarcinomas showed that cancer cells express widely varying levels of HDAC3. The SW480 colon cancer cell line was found to express high levels of HDAC3 compared to other colon cancer cell lines. p21 was poorly induced in SW480 cells relative to the lower HDAC3‐expressing HT‐29 cells.
Colleen C, Spurling, Cassandra A, Godman, Emily J, Noonan, Theodore P, Rasmussen, Daniel W, Rosenberg, Charles, Giardina   +5 more
openaire   +2 more sources

The Biology of HDAC3

2006
Histone deacetylase 3 (HDAC3) is one of four members of the human class I histone deacetylases that repress transcription by deacetylation of histones. This review describes our current knowledge regarding its structure, function, mechanisms of action, and regulation.
openaire   +1 more source

Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3

Neuroscience Letters, 2014
DTNBP1 is a key candidate gene associated with schizophrenia. The expression of its protein product, dysbindin-1, is altered in the brains of schizophrenic patients; however, the physiological functions of dysbindin-1 in the central nervous system are unclear.
Mika, Soma, Min, Wang, Satoshi, Suo, Shoichi, Ishiura   +3 more
openaire   +2 more sources

HDAC3 sets the timer on muscle fuel switching

Nature Medicine, 2017
In a recent study in mice, it is shown that circadian oscillations in genomic histone deactylase 3 (HDAC3) occupancy influence fuel switching and carbon flux in muscle to regulate glucose homeostasis and exercise performance.
openaire   +2 more sources