Results 201 to 210 of about 18,122 (224)

Inhibition of Hdac3 as a Strategy for Developing Novel Diabetes Therapeutics

Epigenomics, 2014
Modulation of histone deacetylase (HDAC) activity has been implicated as a potential therapeutic strategy for multiple diseases. Recent studies have put a greater spotlight on metabolic diseases, in particular Type 1 and Type 2 diabetes, as potential indications for which HDAC inhibition could be beneficial.
Bennett C, Meier, Bridget K, Wagner
openaire   +2 more sources

HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish

Molecular Neurobiology, 2015
Histone deacetylases (HDACs) are involved in multiple developmental processes, but their functions in the development of mechanosensory organs are largely unknown. In the present study, we report the presence of HDAC3 in the zebrafish posterior lateral line primordium and newly deposited neuromasts.
Yingzi, He, Zhengmin, Wang, Shaoyang, Sun, Dongmei, Tang, Wenyan, Li, Renjie, Chai, Huawei, Li   +6 more
openaire   +2 more sources

HDAC3 sets the timer on muscle fuel switching

Nature Medicine, 2017
In a recent study in mice, it is shown that circadian oscillations in genomic histone deactylase 3 (HDAC3) occupancy influence fuel switching and carbon flux in muscle to regulate glucose homeostasis and exercise performance.
openaire   +2 more sources

THE ROLE OF HDAC3 IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE

2018
INTRODUZIONE L?obesit una condizione patologica considerata come una vera e propria epidemia mondiale e una delle principali sfide socio-sanitarie. Questa condizione, infatti, uno dei pi importanti fattori di rischio per le patologie cardiovascolari. Per questa ragione diverse ricerche sono incentrate nello studio della fisiopatologia del tessuto
openaire   +1 more source

Pharmacophore-based virtual screening, 3D QSAR, Docking, ADMET, and MD simulation studies: An in silico perspective for the identification of new potential HDAC3 inhibitors

Computers in Biology and Medicine, 2023
Goverdhan Lanka, Balaram Ghosh
exaly  

Histone deacetylase 3 (HDAC3) inhibitors as anticancer agents: A review

European Journal of Medicinal Chemistry, 2020
Tarun Jha, Sk Abdul Amin
exaly  

HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis

Biochemical Pharmacology, 2021
Enqi Liu, Liang Bai, Rong Wang
exaly  

The Relationship between HDAC3 and Malignant Tumors: A Mini Review

Critical Reviews in Eukaryotic Gene Expression, 2020
Ying Feng, Chongdong Liu
exaly  

HDAC3: taking the SMRT-N-CoRrect road to repression

Oncogene, 2007
Panagiota Karagianni
exaly  

HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches

European Journal of Medicinal Chemistry, 2018
Balaram Ghosh, Tarun Jha
exaly