Results 221 to 230 of about 21,262 (243)

Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients.

Biomarkers in Medicine, 2023
Aim: To investigate the clinical value of HDAC4 in coronary heart disease (CHD) patients. Methods: The serum HDAC4 levels were determined by ELISA in 180 CHD patients and 50 healthy controls.
Zhang Guo, Yanqiang Wu, Qiang Feng, Congcong Wang, Zhenzhen Wang, Yanling Zhu, Xiaonan Lu, Weiwei Chen, Qiuxia Yang, Yanfei Huo   +9 more
semanticscholar   +1 more source

HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre‐eclampsia through the miR‐134‐5p/FOXM1 axis

Molecular Reproduction and Development, 2023
Epigenetics, including histone modifications and noncoding RNAs, affects abnormal placental function in pre‐eclampsia (PE). This study was conducted to explore the role of histone deacetylase 4 (HDAC4) in trophoblast invasion and migration.
Yanli Xu, Xiaodi Kang, Hongli Jiang, Huafang Liu, Wenjing Wang   +4 more
semanticscholar   +1 more source

ABHD5 cleaves HDAC4 to benefit the heart

Nature Metabolism, 2019
A study in Nature Metabolism reveals a hitherto-unknown enzymatic and physiological role of ABHD5, which acts as a protease that couples extracellular cues to the epigenome of cardiomyocytes by cleaving histone deacetylase 4 (HDAC4).
Joshua G. Travers, Timothy A. McKinsey
openaire   +2 more sources

Transcriptional regulation of daily sleep amount by TCF4-HDAC4-CREB complex in mice.

Sleep
Histone deacetylase HDAC4/5 cooperates with cAMP response element-binding protein (CREB) in the transcriptional regulation of daily sleep amount downstream of LKB1-SIK3 kinase cascade in mice.
Rui Zhou, Chaodong Zhang, Rui Gan, Xin Yin, Meng Wang, Bihan Shi, Lin Chen, Chongyang Wu, Qi Li, Qinghua Liu   +9 more
semanticscholar   +1 more source

HDAC4‐AS1/CTCF Transcriptionally Represses HDAC4 Under Stress, Whereas HDAC4 Inhibits Stress‐Induced Syncytiotrophoblast Cellular Pyroptosis by Deacetylating NLRP3 and GSDMD

Cell Biochemistry and Function
ABSTRACTOur previous study reported that histone deacetylase 4 (HDAC4) expression is significantly downregulated in placental tissues of pre‐eclampsia (PE) pregnancies. Cellular pyroptosis is a key event in the pathogenesis of PE that induces the release of factors into the maternal circulation.
Juan Du, Qinghong Ji, Lihua Dong, Lanlan Wang, Gang Xin   +4 more
openaire   +2 more sources

Beside the MEF2 axis: Unconventional functions of HDAC4

Cellular Signalling, 2013
The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s.
Clocchiatti A, DI Giorgio E, Demarchi F, BRANCOLINI, Claudio   +3 more
openaire   +2 more sources

Synthesis and Characterization of Reversible Covalent HDAC4 Inhibitors

2022
Cyanoacrylates define a class of inhibitors which are capable to form a transient covalent bond with a cysteine flanking the binding site, thereby increasing the residence time and prolonging the inhibitory effect on the target protein under nonequilibrium conditions.
Anton, Frühauf, Benjamin, Wolff, Markus, Schweipert, Franz-Josef, Meyer-Almes   +3 more
openaire   +2 more sources

Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

Proceedings of the National Academy of Sciences of the United States of America
Significance Histone deacetylases (HDACs) play a crucial role in gene transcription. Class I HDACs exhibit ubiquitous expression and broad functions, while class II HDACs are tissue specific.
Ka Lung Cheung, Li Zhao, Rajal Sharma, Anurupa Ghosh, Michael Appiah, Yifei Sun, Anbalagan Jaganathan, Yuan Hu, Alannah Lejeune, Feihong Xu, Xinye Han, Xueting Wang, Fan Zhang, Chunyan Ren, M. Walsh, Huabao Xiong, A. Tsankov, Ming-Ming Zhou   +17 more
semanticscholar   +1 more source

KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1

Gerontology, 2022
Objectives: Atherosclerosis (AS) remains a major contributor to death worldwide. This study sought to explore the role of Krüppel-like factor 7 (KLF7) in AS lesions via regulating glucose metabolic reprogramming (GMR) in macrophages.
Fangyuan Chen, Juanli Li, Tao Zheng, Tao Chen, Zuyi Yuan   +4 more
semanticscholar   +1 more source

Regional and subcellular distribution of HDAC4 in mouse brain

Journal of Comparative Neurology, 2009
AbstractHistone deacetylases (HDACs) are part of a system that links epigenetic control of gene expression to a variety of environmental stimuli. Some HDACs, including HDAC4, shuttle between the cytoplasm and nucleus in response to physiological cues such as calcium signaling.
Michael J, Darcy, Kate, Calvin, Katie, Cavnar, Charles C, Ouimet   +3 more
openaire   +2 more sources