Results 231 to 240 of about 21,262 (243)

A12 HDAC4 interacts with huntington and HDAC4 reduction decreases cytoplamsic aggregation and rescues synaptic dysfunction in HD mouse models

Journal of Neurology, Neurosurgery & Psychiatry, 2012
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We have found that HDAC4 associates with mutant exon-1 and full length HTT in vivo in a polyQ length-dependent manner and co-localises predominantly with cytoplasmic inclusions in the brains of HD mouse models.
M Mielcarek, C Landles, A Weiss, A Bradaia, T Seredenina, L Inuabasi, K Wadel, C Touller, R Butler, J Robertson, SA Franklin, DL Smith, L Park, PA Marks, EE Wanker, EN Olson, R Luthi-Carter, H van der Putten, V Beaumont, GP Bates   +19 more
openaire   +1 more source

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsense-mediated mRNA degradation

Abstract Histone deacetylases (HDACs) are essential chromatin regulators and are involved in the regulation of gene expression by removing acetyl groups from histone and non-histone proteins. Histone deacetylase 4 (HDAC4) is known to regulate the process of endochondral ossification in mice by non-enzymatic repression of the activity of the
Harikrishnareddy Paluvai, Mark E. Pepin, Friederike Schreiter, Alireza Saadatmand, Marco Hagenmueller, Johannes Backs   +5 more
openaire   +1 more source

HDAC4 Inhibits NMDA Receptor-Mediated Stimulation of Neurogranin Expression

Molecular Neurobiology
AbstractThe coordination of neuronal wiring and activity within the central nervous system (CNS) is crucial for cognitive function, particularly in the context of aging and neurological disorders. Neurogranin (Ng), an abundant forebrain protein, modulates calmodulin (CaM) activity and deeply influences synaptic plasticity and neuronal processing.
Raquel de Andrés, Elena Martínez-Blanco, F. Javier Díez-Guerra   +2 more
openaire   +3 more sources

Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)

2016
Histone deacetylases (HDACs) regulate various nuclear and cytoplasmic processes. In mammals, these enzymes are divided into four classes, with class II further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, HDAC9) and IIb (HDAC6 and HDAC10). While HDAC6 is mainly cytoplasmic and HDAC10 is pancellular, class IIa HDACs are dynamically shuttled ...
Lin, Li, Xiang-Jiao, Yang
openaire   +2 more sources

Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease

Neuropsychopharmacology, 2023
Xiaoman Dai, Anlan Lin, Lvping Zhuang, Qingyong Zeng, Li-Qiong Cai, Yuanxiang Wei, Hongjie Liang, Weijie Gao, Jing Zhang, Xiaochun Chen   +9 more
semanticscholar   +1 more source

Multilayered screening for multi-targeted anti-Alzheimer’s and anti-Parkinson’s agents through structure-based pharmacophore modelling, MCDM, docking, molecular dynamics and DFT: a case study of HDAC4 inhibitors

In Silico Pharmacology
N. Chhabra, B. Matore, Nisha Lakra, P. Banjare, A. Murmu, A. Bhattacharya, S. Gayen, Jagadish Singh, P. P. Roy   +8 more
semanticscholar   +1 more source

Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas

Cancer Gene Therapy, 2023
G. R. de Sousa, K. B. Salomão, Luis F. P. Nagano, K. Riemondy, P. S. Chagas, L. Veronez, F. Saggioro, S. Marie, J. A. Yunes, I. Cardinalli, S. Brandalise, R. G. de Paula Queiroz, C. Scrideli, A. Donson, N. Foreman, L. Tone, E. Valera   +16 more
semanticscholar   +1 more source

Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1α/VEGFA axis by delivering microRNA-26a-5p

Cell Biology and Toxicology, 2022
Dan Zhang, Jian Du, Min Yu, Linna Suo
semanticscholar   +1 more source

Human Umbilical Cord-Derived Mesenchymal Stem Cells-Exosomes-Delivered miR-375 Targets HDAC4 to Promote Autophagy and Suppress T Cell Apoptosis in Sepsis-Associated Acute Kidney Injury

Applied Biochemistry and Biotechnology
Min Liu, Xiyun Chen
semanticscholar   +1 more source

HDAC4 and 2q37 Deletion Syndrome

2016
Trang Le, Sarah Elsea
openaire   +1 more source