Results 211 to 220 of about 2,934,766 (329)

HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation

Mucosal Immunology, 2019
M. Friedrich, L. Gerbeth, M. Gerling, R. Rosenthal, K. Steiger, C. Weidinger, J. Keye, Hao Wu, F. Schmidt, W. Weichert, B. Siegmund, R. Glauben   +11 more
semanticscholar   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high-grade IDH mutant gliomas. [PDF]

JCI Insight
Sears TK, McCord M, Wang W, Steffens A, McCortney K, Chaliparambil R, Sarkaria JN, Horbinski CM.   +7 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Pseudo‐Natural Products Inspired by Aryloctahydroindole Alkaloids

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
Mesembrine alkaloid pseudo‐natural products were synthesized employing a microwave‐assisted Diels–Alder reaction as a key step. Morphological profiling by cell painting revealed compound‐topology‐dependent mitochondrial fragmentation or inhibition of respiration.
Luca C. Greiner, Freddy A. Bernal, Sasikala Thavam, Maite Brachthäuser, Sonja Sievers, Slava Ziegler, Herbert Waldmann   +6 more
wiley   +1 more source

HDAC Inhibitors Enhance the Chemosensitivity of Osteosarcoma Cells to Etoposide by Suppressing the Hippo/YAP Signaling Pathway. [PDF]

Int J Mol Sci
Cao Z, Chen Y, Chen M, Fan Q, Sun H, Jin D, Liu Y, Xiong Y, Wang D.   +8 more
europepmc   +1 more source

Histone deacetylase (HDAC) inhibitors- based drugs are effective to control Mycobacterium tuberculosis infection and promote the sensibility for rifampicin in MDR strain. [PDF]

Mem Inst Oswaldo Cruz, 2023
Rodríguez-Carlos A, Jacobo-Delgado Y, Santos-Mena AO, García-Hernández MH, De Jesus-Gonzalez LA, Lara-Ramirez EE, Rivas-Santiago B.   +6 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

A short overview of dual targeting HDAC inhibitors. [PDF]

Future Med Chem
Liu WB, Song J, Zhang SY.
europepmc   +1 more source

Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders. [PDF]

Biomolecules, 2023
Villoria-González A, Zierfuss B, Parzer P, Heuböck E, Zujovic V, Waidhofer-Söllner P, Ponleitner M, Rommer P, Göpfert J, Forss-Petter S, Berger J, Weinhofer I.   +11 more
europepmc   +1 more source

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.

Cancer Discovery, 2017
Clare F Malone, Chloe E. Emerson, Rachel Ingraham, William Barbosa, S. Guerra, H. Yoon, Lin L. Liu, F. Michor, M. Haigis, K. Macleod, Ophélia Maertens, K. Cichowski   +11 more
semanticscholar   +1 more source